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    PROCESS FOR MAKING STABLE BACTERIAL EXTRACTS AND THEIR USE AS PHARMACEUTICALS
    1.
    发明公开
    PROCESS FOR MAKING STABLE BACTERIAL EXTRACTS AND THEIR USE AS PHARMACEUTICALS 审中-公开

    公开(公告)号：EP4234026A2

    公开(公告)日：2023-08-30

    申请号：EP23181587.9

    申请日：2020-03-12

    申请人： OM Pharma SA

    发明人： BAUER, Jacques ,  PASQUALI, Christian

    IPC分类号： A61P31/00

    摘要： The present invention relates to novel stable bacterial extract preparations having substantial increased stability overtime, novel methods of preparation thereof, pharmaceutical formulations based on these novel stabilized bacterial extracts, as well as novel routes of administration and delivery devices for treating and/or preventing acute and chronic immunological disorders resulting from infections and/or inflammation and/or neoplasms and/or dysbiosis.

    2,5- OR 2,6-DISUBSTITUTED HYDROQUINONE DERIVATIVES WITH AT LEAST ONE CARBOXY, SULFO OR AMIDO GROUP USEFUL AS MEDICAMENTS
    2.
    发明公开
    2,5- OR 2,6-DISUBSTITUTED HYDROQUINONE DERIVATIVES WITH AT LEAST ONE CARBOXY, SULFO OR AMIDO GROUP USEFUL AS MEDICAMENTS 审中-公开

    公开(公告)号：EP3878837A1

    公开(公告)日：2021-09-15

    申请号：EP20162558.9

    申请日：2020-03-11

    申请人： OM Pharma SA

    发明人： BAUER, Jacques ,  MARTIN, Olivier

    IPC分类号： C07C235/64 ,  C07C66/00 ,  C07C229/38 ,  C07C233/51 ,  C07C275/42 ,  C07C309/51 ,  C07C317/46 ,  C07C323/56 ,  C07D213/79 ,  C07D235/18 ,  C07D257/04 ,  A61K31/196 ,  A61P3/00 ,  A61P35/00 ,  A61P37/00

    摘要： The invention provides hydroquinone derivatives of formula (I), processes of preparation, as well as pharmaceutical compositions and methods of treating and/or preventing e.g. autoimmune, immunological, rheumatology, vascular, ophthalmologic, fibrotic, metabolic and gastro-intestinal disorders, neuroinflammatory and neurodegenerative diseases, neoplasms and cancer associated disorders, hormone related diseases and immunological disorders resulting from viral and bacterial infectious diseases and complications thereof.

    wherein: R a , R b = H, acyl or aryl alkyl; R 1 = COOR 4 , (CH 2 ) n COOR 4 , SO 3 H, (CH 2 ) n SO 3 H or CONH-R 10 ; R 2 and R 3 = H or R 5 , with the proviso that when one of R 2 and R 3 is R 5 , the other is H; R 4 = H, alkyl or aryl alkyl; R 5 = R 6 , R 7 or R 8 ; R 6 = CONH-R 9 , CONHCOR 9 , CONH(CH 2 ) n - R 9 , CONHCH(COOR 4 )(CH 2 ) k R 9 or heteroaryl-R 9 ; k = 0-4; R 7 = optionally substituted benzoheteroaryl ; R 8 = (CH 2 ) m X(CH 2 ) p R 9 ; X = O, S, SO 2 , NH, NAc or N(CH 2 ) q R 9 ; R 9 = optionally substituted aryl, heteroaryl or cycloalkyl ; R 10 = optionally substituted aryl or heteroaryl ; n, m, p and q = independently 1-4.