专利检索 ap:("Olix Pharmaceuticals, Inc.") AND inv:"LEE, Hanna" 第 1 页

1.

发明公开
TREATMENT OF ATOPIC DERMATITIS AND ASTHMA USING RNA COMPLEXES THAT TARGET lL4R , TRPA1, OR F2RL1 审中-公开

公开(公告)号：EP3411480A1

公开(公告)日：2018-12-12

申请号：EP17747070.5

申请日：2017-02-01

申请人： Olix Pharmaceuticals, Inc.

发明人： LEE, Dong-ki , HONG, Sun Woo , LEE, Hanna , YU, Dayeon , EOM, Ji

IPC分类号： C12N15/113 , A61K31/7105 , A61K45/06

CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521

摘要： In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit IL4Rα, TRPA1, and/or F2RL1 expression and are therefore useful for treating atopic dermatitis or asthma.

2.

发明公开
TREATMENT OF ANGIOGENESIS-ASSOCIATED DISEASES USING RNA COMPLEXES THAT TARGET ANGPT2 AND PDGFB 审中-公开

公开(公告)号：EP3411481A1

公开(公告)日：2018-12-12

申请号：EP17747071.3

申请日：2017-02-01

申请人： Olix Pharmaceuticals, Inc.

发明人： LEE, Dong-ki , HONG, Sun Woo , LEE, Tae Yeon , LEE, Sae-Lo-Oom , LEE, Hanna , YU, Dayeon , EOM, Ji

IPC分类号： C12N15/113 , A61K31/7105 , A61K39/395

CPC分类号： C12N15/1136 , A61K31/713 , A61K45/06 , A61K48/00 , C07K16/22 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2320/31

摘要： In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit ANGPT2 and/or PDGFB expression and are therefore useful for treating angiogenesis-associated diseases, such as cancer, AMD, and DME.