公开(公告)号：EP3377630A1

公开(公告)日：2018-09-26

申请号：EP16865834.2

申请日：2016-11-15

申请人： Olix Pharmaceuticals, Inc.

发明人： LEE, Dong-ki ,  HONG, Sun Woo ,  HONG, Isu ,  HWANG, Ji Hye

IPC分类号： C12N15/113 ,  A61K9/00

CPC分类号： C12N15/1138 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2320/32 ,  C12N2310/3521

摘要： In certain aspects, provided herein are RNA complexes that inhibit Myeloid differentiation primary response gene 88 (MyD88) and/or Toll-like receptor 3 (TLR3) and are useful in the treatment of age-related macular degeneration (AMD). In certain aspects, provided herein are pharmaceutical compositions comprising such RNA complexes and methods of using such RNA complexes and pharmaceutical compositions.

公开(公告)号：EP3411480A1

公开(公告)日：2018-12-12

申请号：EP17747070.5

申请日：2017-02-01

申请人： Olix Pharmaceuticals, Inc.

发明人： LEE, Dong-ki ,  HONG, Sun Woo ,  LEE, Hanna ,  YU, Dayeon ,  EOM, Ji

IPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K45/06

CPC分类号： C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2310/3521

摘要： In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit IL4Rα, TRPA1, and/or F2RL1 expression and are therefore useful for treating atopic dermatitis or asthma.

公开(公告)号：EP4454637A2

公开(公告)日：2024-10-30

申请号：EP24195470.0

申请日：2016-11-15

申请人： Olix Pharmaceuticals, Inc.

发明人： LEE, Dong-ki ,  HONG, Sun Woo ,  HONG, Isu ,  HWANG, Ji Hye

IPC分类号： A61K9/00

摘要： In certain aspects, provided herein are RNA complexes that inhibit Myeloid differentiation primary response gene 88 (MyD88) and/or Toll-like receptor 3 (TLR3) and are useful in the treatment of age-related macular degeneration (AMD). In certain aspects, provided herein are pharmaceutical compositions comprising such RNA complexes and methods of using such RNA complexes and pharmaceutical compositions.

公开(公告)号：EP3411481A1

公开(公告)日：2018-12-12

申请号：EP17747071.3

申请日：2017-02-01

申请人： Olix Pharmaceuticals, Inc.

发明人： LEE, Dong-ki ,  HONG, Sun Woo ,  LEE, Tae Yeon ,  LEE, Sae-Lo-Oom ,  LEE, Hanna ,  YU, Dayeon ,  EOM, Ji

IPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K39/395

CPC分类号： C12N15/1136 ,  A61K31/713 ,  A61K45/06 ,  A61K48/00 ,  C07K16/22 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2320/31

摘要： In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit ANGPT2 and/or PDGFB expression and are therefore useful for treating angiogenesis-associated diseases, such as cancer, AMD, and DME.