公开(公告)号：EP2772265A3

公开(公告)日：2015-01-21

申请号：EP14162929.5

申请日：2011-05-16

申请人： Oregon Health & Science University

发明人： Picker, Louis ,  Nelson, Jay, A. ,  Frueh, Klaus ,  Jarvis, Michael, A. ,  Hansen, Scott, G.

IPC分类号： C12N15/869 ,  C12N15/33 ,  A61K39/12 ,  A61P31/12 ,  A61P35/00

CPC分类号： A61K39/12 ,  A61K39/0011 ,  A61K39/08 ,  A61K39/13 ,  A61K39/145 ,  A61K39/21 ,  A61K39/275 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/572 ,  A61K2039/58 ,  C07K14/005 ,  C07K14/045 ,  C07K14/16 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N7/00 ,  C12N15/86 ,  C12N15/869 ,  C12N2710/16111 ,  C12N2710/16134 ,  C12N2710/16141 ,  C12N2710/16143 ,  C12N2710/16162 ,  C12N2710/16171 ,  C12N2710/24134 ,  C12N2730/10134 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2760/14134 ,  C12N2760/16134 ,  C12N2770/32634 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/412 ,  Y02A50/466

摘要： Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.

公开(公告)号：EP2772265B1

公开(公告)日：2018-01-17

申请号：EP14162929.5

申请日：2011-05-16

申请人： Oregon Health & Science University

发明人： Picker, Louis ,  Nelson, Jay, A. ,  Frueh, Klaus ,  Jarvis, Michael, A. ,  Hansen, Scott, G.

IPC分类号： C12N15/869 ,  C12N15/33 ,  A61K39/12 ,  A61P31/12 ,  A61P35/00

CPC分类号： A61K39/12 ,  A61K39/0011 ,  A61K39/08 ,  A61K39/13 ,  A61K39/145 ,  A61K39/21 ,  A61K39/275 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/572 ,  A61K2039/58 ,  C07K14/005 ,  C07K14/045 ,  C07K14/16 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N7/00 ,  C12N15/86 ,  C12N15/869 ,  C12N2710/16111 ,  C12N2710/16134 ,  C12N2710/16141 ,  C12N2710/16143 ,  C12N2710/16162 ,  C12N2710/16171 ,  C12N2710/24134 ,  C12N2730/10134 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2760/14134 ,  C12N2760/16134 ,  C12N2770/32634 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/412 ,  Y02A50/466

摘要： Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.

公开(公告)号：EP2772265A2

公开(公告)日：2014-09-03

申请号：EP14162929.5

申请日：2011-05-16

申请人： Oregon Health & Science University

发明人： Picker, Louis ,  Nelson, Jay, A. ,  Frueh, Klaus ,  Jarvis, Michael, A. ,  Hansen, Scott, G.

IPC分类号： A61K39/12 ,  C12N15/869

CPC分类号： A61K39/12 ,  A61K39/0011 ,  A61K39/08 ,  A61K39/13 ,  A61K39/145 ,  A61K39/21 ,  A61K39/275 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/572 ,  A61K2039/58 ,  C07K14/005 ,  C07K14/045 ,  C07K14/16 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N7/00 ,  C12N15/86 ,  C12N15/869 ,  C12N2710/16111 ,  C12N2710/16134 ,  C12N2710/16141 ,  C12N2710/16143 ,  C12N2710/16162 ,  C12N2710/16171 ,  C12N2710/24134 ,  C12N2730/10134 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2760/14134 ,  C12N2760/16134 ,  C12N2770/32634 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/412 ,  Y02A50/466

摘要： Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.

摘要翻译： 本文描述了编码异源抗原如病原体特异性抗原或肿瘤抗原的重组恒河猴巨细胞病毒（RhCMV）和人巨细胞病毒（HCMV）载体。 重组载体引发和维持对异源抗原特异性的高水平细胞和体液免疫应答。 重组RhCMV和HCMV载体可用于例如治疗或预防感染性疾病或癌症。 在一些实例中，重组RhCMV或HCMV载体可以包括编码免疫调节蛋白的基因中的缺失。 在一些实例中，重组RhCMV或HCMV载体在细胞内复制的能力可能是缺陷或受损的，在宿主内传播或通过在CMV复制，传播或扩增中必需或增加的一个或多个基因中包含缺失而在宿主间扩散 传播。