公开(公告)号：EP3211003A1

公开(公告)日：2017-08-30

申请号：EP16305218.6

申请日：2016-02-24

申请人： Institut Pasteur

发明人： CHAKRABARTI, Lisa, Amita ,  BENATI, Daniela ,  GALPERIN, Moran

IPC分类号： C07K14/725 ,  A61K48/00 ,  A61K35/17 ,  C07K16/10 ,  C07K14/16 ,  C12N5/0783 ,  C12N15/867 ,  A61P31/18

CPC分类号： C07K14/7051 ,  A61K35/17 ,  A61K38/00 ,  A61K48/00 ,  C07K14/161 ,  C07K16/1054 ,  C07K2317/34 ,  C12N5/0636 ,  C12N15/86 ,  C12N2740/15041

摘要： The present invention pertains to the field of T Cell receptors (TCR) identification and clonotyping, and especially concerns particular TCRs identified by clonotyping of a HIV-specific TCR repertoire, or fragments thereof. the invention relates especially to TCRs recognizing Gag peptide located between positions 293-312 in the GAG protein of HIV-1.
The present invention further relates to nucleic acid constructs suitable as means for cloning or expressing nucleic acid molecules or TCRs of the invention, such as plasmids, vectors, especially lentiviral transfer vectors.
The invention is of particular interest in the context of therapeutic treatment of human beings seropositive for HIV.

摘要翻译： 本发明涉及T细胞受体（TCR）识别和克隆分型领域，特别涉及通过HIV特异性TCR库或其片段的克隆型鉴定的特定TCR。 本发明尤其涉及识别位于HIV-1的GAG蛋白中​​第293-312位之间的Gag肽的TCR。 本发明进一步涉及适合作为用于克隆或表达本发明的核酸分子或TCR（例如质粒，载体，特别是慢病毒转移载体）的手段的核酸构建体。 本发明特别关注人类对HIV血清阳性的治疗性处理。

公开(公告)号：EP1778282B1

公开(公告)日：2016-03-30

申请号：EP05774364.3

申请日：2005-08-17

申请人： Institut Gustave Roussy ,  Centre National de la Recherche Scientifique ,  Université de Paris-Sud XI

发明人： RENARD, Martial ,  MANGENEY, Marianne ,  HEIDMANN, Thierry

IPC分类号： C07K14/005 ,  C07K14/16 ,  A61K39/21 ,  A61K38/16

CPC分类号： A61K39/21 ,  A61K38/162 ,  A61K2300/00 ,  C07K14/005 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N2740/15022 ,  C12N2740/16322 ,  G01N2333/163

公开(公告)号：EP2569436A4

公开(公告)日：2013-11-27

申请号：EP11781407

申请日：2011-05-16

申请人： UNIV OREGON HEALTH & SCIENCE

发明人： PICKER LOUIS ,  NELSON JAY A ,  FRUEH KLAUS ,  JARVIS MICHAEL A ,  HANSEN SCOTT G

IPC分类号： C12N15/869 ,  A61K39/12 ,  A61P31/12 ,  A61P35/00 ,  C12N15/33

CPC分类号： C12N7/00 ,  A61K39/0011 ,  A61K39/08 ,  A61K39/12 ,  A61K39/13 ,  A61K39/145 ,  A61K39/275 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/572 ,  A61K2039/58 ,  C07K14/005 ,  C07K14/045 ,  C07K14/16 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N15/86 ,  C12N15/869 ,  C12N2710/16111 ,  C12N2710/16134 ,  C12N2710/16141 ,  C12N2710/16143 ,  C12N2710/16162 ,  C12N2710/16171 ,  C12N2710/24134 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2760/14134 ,  C12N2760/16134 ,  C12N2770/32634

摘要： Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.

摘要翻译： 本文描述了编码异源抗原如病原体特异性抗原或肿瘤抗原的重组恒河猴巨细胞病毒（RhCMV）和人巨细胞病毒（HCMV）载体。 重组载体引发和维持对异源抗原特异性的高水平细胞和体液免疫应答。 重组RhCMV和HCMV载体可用于例如治疗或预防感染性疾病或癌症。 在一些实例中，重组RhCMV或HCMV载体可以包括编码免疫调节蛋白的基因中的缺失。 在一些实例中，重组RhCMV或HCMV载体在细胞内复制的能力可能是缺陷或受损的，在宿主内传播或通过在CMV复制，传播或扩增中必需或增加的一个或多个基因中包含缺失而在宿主中扩散 传播。

公开(公告)号：EP2336175A1

公开(公告)日：2011-06-22

申请号：EP10179020.2

申请日：2001-12-05

申请人： Abbott Laboratories

发明人： Lou, Sheng, C. ,  Hunt, Jeffrey, C. ,  Konrath, John, G. ,  Qiu, Xiaoxing ,  Scheffel, James, W. ,  Tyner, Joan, D.

IPC分类号： C07K16/10 ,  C12N5/20 ,  G01N33/577 ,  G01N33/569 ,  G01N33/68 ,  C07K14/16

CPC分类号： C07K16/1054 ,  C07K7/08 ,  C07K14/005 ,  C07K14/161 ,  C07K2317/34 ,  C12N2740/16211 ,  C12N2740/16222 ,  G01N33/56983 ,  G01N33/68

摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.

公开(公告)号：EP1504266A2

公开(公告)日：2005-02-09

申请号：EP03749938.1

申请日：2003-05-09

申请人： Bio-Rad Pasteur

发明人： RIEUNIER, François ,  FEYSSAGUET, Muriel ,  HENRIOT, Stéphanie ,  LAMBERT, Nadine

IPC分类号： G01N33/569 ,  G01N33/576 ,  C07K14/18

CPC分类号： C07K14/1833 ,  C07K14/005 ,  C07K14/161 ,  C07K16/109 ,  C07K16/42 ,  C07K2317/32 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2770/24222 ,  G01N33/569 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/5767 ,  G01N2333/16 ,  G01N2333/18

摘要： The invention concerns a method for in vitro detection of an infection mediated by a microorganism, such as the hepatitis C virus, in a biological sample, by simultaneous detection of an antigen of said microorganism and antibodies directed against said antigen, as well as reagents and kits for implementing said method.

公开(公告)号：EP1341820A2

公开(公告)日：2003-09-10

申请号：EP01273730.0

申请日：2001-12-05

申请人： Abbott Laboratories

发明人： LOU, Sheng, C. ,  HUNT, Jeffrey, C. ,  KONRATH, John, G. ,  QIU, Xiaoxing ,  SCHEFFEL, James, W. ,  TYNER, Joan, D.

IPC分类号： C07K16/10

CPC分类号： C07K16/1054 ,  C07K7/08 ,  C07K14/005 ,  C07K14/161 ,  C07K2317/34 ,  C12N2740/16211 ,  C12N2740/16222 ,  G01N33/56983 ,  G01N33/68

摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.

公开(公告)号：EP2772265B1

公开(公告)日：2018-01-17

申请号：EP14162929.5

申请日：2011-05-16

申请人： Oregon Health & Science University

发明人： Picker, Louis ,  Nelson, Jay, A. ,  Frueh, Klaus ,  Jarvis, Michael, A. ,  Hansen, Scott, G.

IPC分类号： C12N15/869 ,  C12N15/33 ,  A61K39/12 ,  A61P31/12 ,  A61P35/00

CPC分类号： A61K39/12 ,  A61K39/0011 ,  A61K39/08 ,  A61K39/13 ,  A61K39/145 ,  A61K39/21 ,  A61K39/275 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/572 ,  A61K2039/58 ,  C07K14/005 ,  C07K14/045 ,  C07K14/16 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N7/00 ,  C12N15/86 ,  C12N15/869 ,  C12N2710/16111 ,  C12N2710/16134 ,  C12N2710/16141 ,  C12N2710/16143 ,  C12N2710/16162 ,  C12N2710/16171 ,  C12N2710/24134 ,  C12N2730/10134 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2760/14134 ,  C12N2760/16134 ,  C12N2770/32634 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/412 ,  Y02A50/466

摘要： Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.

公开(公告)号：EP2772265A2

公开(公告)日：2014-09-03

申请号：EP14162929.5

申请日：2011-05-16

申请人： Oregon Health & Science University

发明人： Picker, Louis ,  Nelson, Jay, A. ,  Frueh, Klaus ,  Jarvis, Michael, A. ,  Hansen, Scott, G.

IPC分类号： A61K39/12 ,  C12N15/869

CPC分类号： A61K39/12 ,  A61K39/0011 ,  A61K39/08 ,  A61K39/13 ,  A61K39/145 ,  A61K39/21 ,  A61K39/275 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/572 ,  A61K2039/58 ,  C07K14/005 ,  C07K14/045 ,  C07K14/16 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N7/00 ,  C12N15/86 ,  C12N15/869 ,  C12N2710/16111 ,  C12N2710/16134 ,  C12N2710/16141 ,  C12N2710/16143 ,  C12N2710/16162 ,  C12N2710/16171 ,  C12N2710/24134 ,  C12N2730/10134 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2760/14134 ,  C12N2760/16134 ,  C12N2770/32634 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/412 ,  Y02A50/466

摘要： Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.

摘要翻译： 本文描述了编码异源抗原如病原体特异性抗原或肿瘤抗原的重组恒河猴巨细胞病毒（RhCMV）和人巨细胞病毒（HCMV）载体。 重组载体引发和维持对异源抗原特异性的高水平细胞和体液免疫应答。 重组RhCMV和HCMV载体可用于例如治疗或预防感染性疾病或癌症。 在一些实例中，重组RhCMV或HCMV载体可以包括编码免疫调节蛋白的基因中的缺失。 在一些实例中，重组RhCMV或HCMV载体在细胞内复制的能力可能是缺陷或受损的，在宿主内传播或通过在CMV复制，传播或扩增中必需或增加的一个或多个基因中包含缺失而在宿主间扩散 传播。

公开(公告)号：EP2309269A1

公开(公告)日：2011-04-13

申请号：EP10174056.1

申请日：2005-09-02

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Golding, Hana ,  Khurana, Surender

IPC分类号： G01N33/569 ,  G01N33/538

CPC分类号： G01N33/6854 ,  C07K14/005 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  G01N33/56988 ,  G01N2333/162 ,  G01N2469/20

摘要： This invention relates to compositions and methods or the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-1) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-IIIV-1 antibodies.

摘要翻译： 本发明涉及组合物和方法或检测免疫缺陷病毒感染，特别是免疫缺陷病毒-1（HIV-1）感染。 本发明特别涉及可用于其血清可含有疫苗产生的抗IIIV-1抗体的HIV疫苗受体中的组合物和方法。

公开(公告)号：EP2295974A1

公开(公告)日：2011-03-16

申请号：EP10174064.5

申请日：2005-09-02

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Golding, Hana ,  Khurana, Surender

IPC分类号： G01N33/569 ,  G01N33/538

CPC分类号： G01N33/6854 ,  C07K14/005 ,  C07K14/161 ,  C07K14/162 ,  C07K14/163 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  G01N33/56988 ,  G01N2333/162 ,  G01N2469/20

摘要： This invention relates to compositions and methods or the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-1) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies.

摘要翻译： 本发明涉及组合物和方法或检测免疫缺陷病毒感染，特别是免疫缺陷病毒-1（HIV-1）感染。 本发明特别涉及可用于其血清可含有疫苗产生的抗HIV-1抗体的HIV疫苗受体中的组合物和方法。