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15 条记录 (耗时 0.012 秒)

    Pharmaceutical compositions comprising cyclosporin as active ingredient
    1.
    发明公开
    Pharmaceutical compositions comprising cyclosporin as active ingredient 有权
    Pharmazeutische Zusammensetzung enthaltend Cyclosprin als aktiven Bestandteil

    公开(公告)号：EP1151755A1

    公开(公告)日：2001-11-07

    申请号：EP00201627.7

    申请日：2000-05-04

    申请人： Panacea Biotec Limited

    发明人： Singh, Amarjit ,  Jain, Rajesh

    IPC分类号： A61K38/13 ,  A61K9/48 ,  A61K9/107 ,  A61P37/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

    CPC分类号： A61K47/10 ,  A61K9/1075 ,  A61K38/13 ,  A61K47/14 ,  A61K47/44

    摘要： The invention disclosed a homogenous substantially alcohol free composition of Cyclosporin which comprises a Cyclosporin in a hydrophilic carrier medium comprising propylene glycol, esters of propylene glycol with C4 to C12 fatty acids and polyoxyethylene hydrogenated castor oils wherein the ingredients are present in the following ranges, Cyclosporin 1 - 25% w/w, Propylene Glycol 2.5 - 70% w/w. Esters of Propylene Glycol with C4 to C12 fatty acids 2.5 - 70% w/w and Polyoxyethylene hydrogenated Castor oils 2.5 - 70% w/w.

    摘要翻译： 本发明公开了一种均匀的基本上无醇的环孢菌素组合物，其在亲水性载体介质中包含环糊精，其包含丙二醇，丙二醇与C 4 -C 12脂肪酸的酯和聚氧乙烯氢化蓖麻油，其中所述成分存在于以下范围内，环孢菌素 1 - 25％w / w，丙二醇2.5 - 70％w / w。 具有C4至C12脂肪酸的丙二醇的酯为2.5-70％w / w，聚氧乙烯氢化蓖麻油为2.5-70％w / w。

    Cyclosporin compositions
    4.
    发明公开
    Cyclosporin compositions 有权
    环孢菌素Zusammensetzungen

    公开(公告)号：EP0985412A2

    公开(公告)日：2000-03-15

    申请号：EP99202660.9

    申请日：1999-08-16

    申请人： Panacea Biotec Limited

    发明人： Singh, Amarjit ,  Jain, Rajesh

    IPC分类号： A61K9/48 ,  A61K38/13

    CPC分类号： A61K47/44 ,  A61K9/1075 ,  A61K9/4858 ,  A61K9/4866 ,  A61K38/13 ,  A61K47/10 ,  A61K47/14 ,  Y02A50/411 ,  Y02A50/423

    摘要： The invention disclosed a homogenous substantially alcohol free composition of Cyclosporin which comprises a Cyclosporin in a hydrophilic carrier medium comprising propylene glycol, esters of propylene glycol with C4 to C12 fatty acids and polyoxyethylene hydrogenated castor oils wherein the ingredients are present in the following ranges, Cyclosporin 1 - 25% w/w, Propylene Glycol 5 - 50% w/w, Esters of Propylene Glycol with C4 to C12 fatty acids 10 - 40% w/w and Polyoxyethylene hydrogenated Castor oils 25 - 60% w/w.

    摘要翻译： 本发明公开了一种均匀的基本上无醇的环孢菌素组合物，其在亲水性载体介质中包含环糊精，其包含丙二醇，丙二醇与C 4 -C 12脂肪酸的酯和聚氧乙烯氢化蓖麻油，其中所述成分存在于以下范围内，环孢菌素 1 - 25％w / w，丙二醇5 - 50％w / w，丙二醇与C4至C12脂肪酸的酯为10 - 40％w / w，聚氧乙烯氢化蓖麻油为25 - 60％w / w。

    Pharmaceutical compositions containing NSAIDs and piperine
    6.
    发明公开
    Pharmaceutical compositions containing NSAIDs and piperine 失效
    Pharmazeutische Zusammensetzungen，死于NSAIDs和Piperine焚化

    公开(公告)号：EP0935964A1

    公开(公告)日：1999-08-18

    申请号：EP98102450.8

    申请日：1998-02-12

    申请人： PANACEA BIOTEC LIMITED

    发明人： Singh, Amarjit ,  Jain, Rajesh

    IPC分类号： A61K31/445

    CPC分类号： A61K31/445 ,  A61K2300/00

    摘要： A novel composition for increasing the bioavailability of Non-steroidal Anti-inflammatory Drugs (NSAIDs) or derivatives thereof particularly those belonging to the category which exhibits its activity by selectively inhibiting cyclooxygenases-II (COX-II) and/or lipooxygenases is disclosed. The composition is characterised in having clinically significant increased bio-availability when compared to the known compositions of the drugs. The pharmaceutical compositions comprise NSAIDs and/or derivatives thereof and Piperine, its metabolites, structural analogues or isomers of Piperine. Enhanced bio-availability results in the reduction of the dose of NSAIDs or derivatives thereof and hence will reduce the cost of therapy in diseases like arthritis which require long term therapies which results from the high cost of the drugs. Also as the cost of therapy will decrease, NSAIDs such as Nimesulide can be put to much wider use in newer indications. Enhanced bio-availability of NSAIDs results in the reduction of dose-related side effects.

    摘要翻译： 公开了一种用于增加非甾体抗炎药（NSAID）或其衍生物的生物利用度的新型组合物，特别是那些属于通过选择性抑制环氧合酶-2（COX-II）和/或脂氧合酶显示其活性的类别的组合物。 与已知的药物组合物相比，该组合物的特征在于具有临床显着增加的生物利用度。 药物组合物包含NSAIDs和/或其衍生物，Piperine及其代谢物，Piperine的结构类似物或异构体。 增强的生物可利用性导致NSAID或其衍生物的剂量减少，因此将降低需要由药物成本高的长期疗法的关节炎等疾病中的治疗成本。 此外，随着治疗费用的降低，非甾体抗炎药（如尼美舒利）可以在较新的适应症中得到更广泛的应用。 NSAIDs的增强的生物利用度导致剂量相关副作用的减少。

    Injectable compositions containing Nimesulide
    7.
    发明公开
    Injectable compositions containing Nimesulide 失效
    Injizierbare Zusammensetzungen enthaltend尼美舒利

    公开(公告)号：EP0812591A1

    公开(公告)日：1997-12-17

    申请号：EP96304461.5

    申请日：1996-06-14

    申请人： Panacea Biotec Limited

    发明人： Jain, Rajesh ,  Singh, Amarjit, Dr.

    IPC分类号： A61K31/63

    CPC分类号： A61K31/18 ,  A61K9/0019 ,  A61K47/14 ,  A61K47/18

    摘要： Novel therapeutic anti-inflammatory and analgesic compositions are disclosed containing Nimesulide, i.e. N-(4-nitro, 2 phenoxyphenyl) methane sulphonamide for use intramuscularly, also a process for their preparation.

    摘要翻译： 公开了新颖的治疗性抗炎和止痛组合物，其含有尼美舒利，即用于肌内使用的N-（4-硝基，2苯氧基苯基）甲磺酰胺，也是其制备方法。

    Cyclosporin composition comprising an hydrophilic carrier
    10.
    发明公开
    Cyclosporin composition comprising an hydrophilic carrier 有权
    Zusammensetzung叮咬环己酮在einem亲水Träger

    公开(公告)号：EP0982035A1

    公开(公告)日：2000-03-01

    申请号：EP98306607.7

    申请日：1998-08-18

    申请人： Panacea Biotec Limited

    发明人： Singh, Amarjit ,  Jain, Rajesh

    IPC分类号： A61K38/13 ,  A61K9/48 ,  A61K9/107 ,  A61K9/10

    CPC分类号： A61K47/44 ,  A61K9/1075 ,  A61K9/4858 ,  A61K9/4866 ,  A61K38/13 ,  A61K47/10 ,  A61K47/14 ,  Y02A50/411 ,  Y02A50/423

    摘要： A homogeneous substantially alcohol free, transparent solution of a cyclosporin which is clear, stable, flowable and easily measurable at a temperature of 15° to 45°C, which comprises a solution of a cyclosporin in a hydrophilic carrier medium comprising (1) propylene glycol, (2) a transesterification product of a natural vegetable oil triglyceride and a polyalkylene polyol, (3) a polyoxyethylene hydrogenated castor oil product and (4) triacetin.

    摘要翻译： 一种在15°至45℃的温度下清晰，稳定，可流动和容易测量的环孢菌素的基本均匀的无醇透明溶液，其包含环己烷在亲水载体介质中的溶液，其包含（1）丙二醇 ，（2）天然植物油甘油三酯和聚亚烷基多元醇的酯交换反应产物，（3）聚氧乙烯氢化蓖麻油产物和（4）三醋精。