公开(公告)号：EP3634953A1

公开(公告)日：2020-04-15

申请号：EP18813494.4

申请日：2018-06-05

申请人： PTC Therapeutics, Inc.

发明人： WOLL, Matthew, G. ,  AMEDZO, Lukiana ,  BABU, Suresh ,  BARRAZA, Scott, J. ,  BHATTACHARYYA, Anuradha ,  KARP, Gary, Mitchell ,  MAZZOTTI, Anthony, R. ,  NARASIMHAN, Jana ,  PATEL, Jigar ,  TURPOFF, Anthony ,  XU, Zhenrong

IPC分类号： C07D239/74 ,  C07D239/94 ,  C07D239/95

公开(公告)号：EP4434990A1

公开(公告)日：2024-09-25

申请号：EP24168248.3

申请日：2019-06-25

申请人： PTC Therapeutics, Inc.

发明人： SYDORENKO, Nadiya ,  ALAM, Rauful ,  ARNOLD, Michael A. ,  BABU, Suresh ,  BHATTACHARYYA, Anuradha ,  CHEN, Guangming ,  GERASYUTO, Aleksey I. ,  KARP, Gary Mitchell ,  KASSICK, Andrew J. ,  MAZZOTTI, Anthony R. ,  MOON, Young-Choon ,  NARASIMHAN, Jana ,  PATEL, Jigar ,  TURPOFF, Anthony ,  WOLL, Matthew G. ,  YAN, Wuming ,  ZHANG, Nanjing

IPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  A61K31/4985 ,  A61K31/5025

CPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28

摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：EP4151627A1

公开(公告)日：2023-03-22

申请号：EP22203869.7

申请日：2018-06-05

申请人： PTC Therapeutics, Inc.

发明人： WOLL, Matthew ,  AMEDZO, Lukiana ,  BABU, Suresh ,  BARRAZA, Scott ,  BHATTACHARYYA, Anuradha ,  KARP, Gary ,  MAZZOTTI, Anthony ,  NARASIMHAN, Jana ,  PATEL, Jigar ,  TURPOFF, Anthony ,  XU, Zhenrong

IPC分类号： C07D239/74 ,  C07D239/94 ,  C07D239/95 ,  A61P25/14 ,  A61K31/4709 ,  A61K31/4725

摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：EP3814357A1

公开(公告)日：2021-05-05

申请号：EP19736566.1

申请日：2019-06-25

申请人： PTC Therapeutics, Inc.

发明人： SYDORENKO, Nadiya ,  ALAM, Md Rauful ,  ARNOLD, Michael A. ,  BABU, Suresh ,  BHATTACHARYYA, Anuradha ,  CHEN, Guangming ,  GERASYUTO, Aleksey I. ,  KARP, Gary Mitchell ,  KASSICK, Andrew J. ,  MAZZOTTI, Anthony R. ,  MOON, Young-Choon ,  NARASIMHAN, Jana ,  PATEL, Jigar ,  TURPOFF, Anthony ,  WOLL, Matthew G. ,  YAN, Wuming ,  ZHANG, Nanjing

IPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/28 ,  A61K31/4985 ,  A61K31/5025