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公开(公告)号：EP4434990A1
公开(公告)日：2024-09-25
申请号：EP24168248.3
申请日：2019-06-25
发明人： SYDORENKO, Nadiya , ALAM, Rauful , ARNOLD, Michael A. , BABU, Suresh , BHATTACHARYYA, Anuradha , CHEN, Guangming , GERASYUTO, Aleksey I. , KARP, Gary Mitchell , KASSICK, Andrew J. , MAZZOTTI, Anthony R. , MOON, Young-Choon , NARASIMHAN, Jana , PATEL, Jigar , TURPOFF, Anthony , WOLL, Matthew G. , YAN, Wuming , ZHANG, Nanjing
IPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00 , A61P25/00 , A61P25/14 , A61P25/28 , A61K31/4985 , A61K31/5025
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00 , A61P25/00 , A61P25/14 , A61P25/28
摘要： The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.-
公开(公告)号：EP2797592A1
公开(公告)日：2014-11-05
申请号：EP12862080.4
申请日：2012-12-28
发明人： WOLL, Matthew G. , CHEN, Guangming , CHOI, Soongyu , DAKKA, Amal , HUANG, Song , KARP, Gary Mitchell , LEE, Chang-Sun , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PAUSHKIN, Sergey , QI, Hongyan , TURPOFF, Anthony A. , WEETALL, Marla L. , WELCH, Ellen , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/353
CPC分类号： C07D487/04 , C07D231/12 , C07D311/16 , C07D311/18 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.
摘要翻译： 本文提供了化合物，其组合物以及用于治疗脊髓性肌萎缩的用途。 在具体的实施方案中，本文提供了可用于调节SMN2的外显子7包含到从SMN2基因转录的mRNA中的形式的化合物。 在另一个具体的实施方案中，本文提供了可用于调节SMN1的外显子7包含到从SMN1基因转录的mRNA中的形式的化合物。 在又一个实施方案中，本文提供了可用于调节SMN1和SMN2的外显子7包含在分别从SMN1和SMN2基因转录的mRNA中的形式的化合物。
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公开(公告)号：EP2809322B9
公开(公告)日：2019-10-30
申请号：EP13740919.9
申请日：2013-01-25
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公开(公告)号：EP2809322B1
公开(公告)日：2019-05-15
申请号：EP13740919.9
申请日：2013-01-25
发明人： CHEN, Guangming , DAKKA, Amal , KARP, Gary Mitchell , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , WEETALL, Marla L. , WELCH, Ellen , ZHAO, Xin
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
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公开(公告)号：EP4219466A1
公开(公告)日：2023-08-02
申请号：EP23162466.9
申请日：2020-05-12
发明人： SYDORENKO, Nadiya , ALAM, Rauful , AMEDZO, Lukiana , ARNOLD, Michael A. , BABU, Suresh , BHATTACHARYYA, Anuradha , KARP, Gary Mitchell , KENTON, Nathaniel T. , LUONG, Tom Tuan , MAZZOTTI, Anthony R. , MOON, Young-Choon , MORRILL, Christie , MSZAR, Nicholas W. , NARASIMHAN, Jana , PATEL, Jigar S. , REN, Hongyu , TURPOFF, Anthony , WANG, Gang , WOLL, Matthew G. , ZHANG, Nanjing , ZHANG, Xiaoyan
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61K31/501 , A61K31/53 , A61P25/28
摘要： The present description relates to compounds (I), forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.-
6.发明公开COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE 审中-公开VERBINDUNGEN ZUR NONSENSE-UNTERDRÜCKUNGUND VERFAHREN ZU DEREN VERWENDUNG
公开(公告)号：EP2939674A1
公开(公告)日：2015-11-04
申请号：EP15168072.5
申请日：2005-10-13
发明人： ALMSTEAD, Neil , CHEN, Guangming , KARP, Gary Mitchell , WELCH, Ellen , WILDE, Richard Gerald , CAMPBELL, Jeffrey Allen
IPC分类号： A61K31/4245 , A61K31/433 , A61P35/00 , C07D271/10 , C07D407/04 , C07D413/04 , C07D413/10 , C07D417/10 , C07D513/04 , C07D487/04 , C07D271/06 , C07D263/32 , C07D231/12 , C07D277/30 , C07D285/08 , C07D333/24 , C07D249/08 , C07D409/10
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods of Formula (1-A)
, and such compounds for use in the treatment or prevention of diseases associated with nonsense mutations in an mRNA, such as for suppressing premature translation termination associated with a nonsense mutation in an mRNA.摘要翻译： 本发明涉及式（1-A）的方法，以及用于治疗或预防与mRNA中的无义突变有关的疾病的化合物，例如用于抑制与mRNA中的无义突变相关的过早翻译终止。
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公开(公告)号：EP1984332A2
公开(公告)日：2008-10-29
申请号：EP07718004.0
申请日：2007-01-16
发明人： KARP, Gary Mitchell , AREFOLOV, Alexander , REN, Hongyu , TURPOFF, Anthony Allan , WILDE, Richard Gerald , TAKASUGI, James Jan , HWANG, Peter Seongwoo , CHEN, Guangming , CAMPBELL, Jeffrey, Allen, c/o S*Bio Pte Ltd , LI, Chunshi , PAGET, Steven , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHU, Jin
IPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , A61K31/405 , A61P31/12
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：EP4288059A1
公开(公告)日：2023-12-13
申请号：EP22750322.4
申请日：2022-02-02
发明人： ARACHCHILAGE, Gayan Mirihana , ARNOLD, Michael A. , BARRAZA, Scott , BHATTACHARYYA, Anuradha , KARP, Gary Mitchell
IPC分类号： A61K31/519
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公开(公告)号：EP4288054A1
公开(公告)日：2023-12-13
申请号：EP22750320.8
申请日：2022-02-02
发明人： ARACHCHILAGE, Gayan Mirihana , ARNOLD, Michael A. , BARRAZA, Scott , BHATTACHARYYA, Anuradha , KARP, Gary Mitchell
IPC分类号： A61K31/4743
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公开(公告)号：EP3814357A1
公开(公告)日：2021-05-05
申请号：EP19736566.1
申请日：2019-06-25
发明人： SYDORENKO, Nadiya , ALAM, Md Rauful , ARNOLD, Michael A. , BABU, Suresh , BHATTACHARYYA, Anuradha , CHEN, Guangming , GERASYUTO, Aleksey I. , KARP, Gary Mitchell , KASSICK, Andrew J. , MAZZOTTI, Anthony R. , MOON, Young-Choon , NARASIMHAN, Jana , PATEL, Jigar , TURPOFF, Anthony , WOLL, Matthew G. , YAN, Wuming , ZHANG, Nanjing
IPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00 , A61P25/00 , A61P25/14 , A61P25/28 , A61K31/4985 , A61K31/5025
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