专利检索 ap:("Pfizer Italia S.r.l.") AND inv:"ORSINI, Paolo" 第 1 页

1.

发明授权
PYRIMIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS 有权
标题翻译： PYRIMIDYLPYRROLDERIVATE，作为激酶抑制剂的工作

公开(公告)号：EP1660475B1

公开(公告)日：2008-05-28

申请号：EP04763883.8

申请日：2004-08-06

申请人： Pfizer Italia S.r.l.

发明人： VANOTTI, Ermes , D'ALESSIO, Roberto , TIBOLLA, Marcellino , VARASI, Mario , MONTAGNOLI, Alessia , SANTOCANALE, Corrado , ORSINI, Paolo , PILLAN, Antonio

IPC分类号： C07D401/04 , C07D519/00 , A61K31/506 , A61K31/52 , A61P35/00 , A61P25/28 , A61P31/12 , A61P37/00 , A61P13/08 , A61P17/06 , A61P9/10 , A61P11/00 , A61P19/02 , A61P13/12 , A61K45/06

CPC分类号： C07D471/04 , A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , A61K2300/00

摘要： Pyrimidylpyrrole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

2.

发明授权
AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS 有权
标题翻译：氮杂吲哚衍生物，其制造方法及其作为抗肿瘤药

公开(公告)号：EP1309590B1

公开(公告)日：2007-09-19

申请号：EP01943522.1

申请日：2001-06-13

申请人： Pfizer Italia S.r.l.

发明人： LONGO, Antonio , BRASCA, Maria, Gabriella , ORSINI, Paolo , TRAQUANDI, Gabriella , PITTALA', Valeria , VULPETTI, Anna , VARASI, Mario , PEVARELLO, Paolo

IPC分类号： C07D471/04 , A61K31/437 , A61P35/04

CPC分类号： C07D471/04

摘要： Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I), as per the specification, and wherein R is a hydrogen or halogen atom or a group selected from -CN, -OH, -OCOR4, -(CH2)nNH2, -(CH2)nNHR4, -(CH2)nNHCOR4, -(CH2)nNHCONR4R5, -(CH2)nNHCOOR4, or -(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R¿2? is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from -CONR4R5, -COOR4, -CONHOR4, -SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed; these compounds are useful for treating cell proliferative disorders associated with an altered cell cycle dependent kinase activity.

3.

发明授权
3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权
标题翻译： 3（5） - 脲基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药

公开(公告)号：EP1202734B1

公开(公告)日：2007-05-02

申请号：EP00955241.5

申请日：2000-08-11

申请人： Pfizer Italia S.r.l. , Pharmacia & Upjohn Company LLC

发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S.

IPC分类号： A61K31/415 , A61K31/496 , C07D231/40 , C07D403/12

CPC分类号： C07D231/40 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/5377

摘要： 3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.