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1.发明授权AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS 有权氮杂吲哚衍生物，其制造方法及其作为抗肿瘤药
公开(公告)号：EP1309590B1
公开(公告)日：2007-09-19
申请号：EP01943522.1
申请日：2001-06-13
申请人： Pfizer Italia S.r.l.
发明人： LONGO, Antonio , BRASCA, Maria, Gabriella , ORSINI, Paolo , TRAQUANDI, Gabriella , PITTALA', Valeria , VULPETTI, Anna , VARASI, Mario , PEVARELLO, Paolo
IPC分类号： C07D471/04 , A61K31/437 , A61P35/04
CPC分类号： C07D471/04
摘要： Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I), as per the specification, and wherein R is a hydrogen or halogen atom or a group selected from -CN, -OH, -OCOR4, -(CH2)nNH2, -(CH2)nNHR4, -(CH2)nNHCOR4, -(CH2)nNHCONR4R5, -(CH2)nNHCOOR4, or -(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R¿2? is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from -CONR4R5, -COOR4, -CONHOR4, -SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed; these compounds are useful for treating cell proliferative disorders associated with an altered cell cycle dependent kinase activity.
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2.发明授权PHENYLACETAMIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权苯乙酰胺基噻唑化合物，工艺作为生产，它们作为抗肿瘤药
公开(公告)号：EP1406899B1
公开(公告)日：2006-11-15
申请号：EP02760213.5
申请日：2002-07-02
申请人： Pfizer Italia S.r.l.
发明人： PEVARELLO, Paolo , AMICI, Raffaella , VILLA, Manuela , SALOM, Barbara , VULPETTI, Anna , VARASI, Mario , BRASCA, Maria, Gabriella , TRAQUANDI, Gabriella , NESI, Marcella
IPC分类号： C07D417/12 , C07D277/46 , A61K31/425 , A61P35/00
CPC分类号： C07D417/12 , C07D277/46
摘要： Compounds represented by formula (I), as defined in the description, wherein R is a hydrogen atom or a methyl group and R1 is a group as defined in the specification, or a pharmaceutically acceptable salt thereof, are disclosed; the said compounds are useful in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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3.发明授权ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS 有权芳羰噻唑衍生物及其作为抗肿瘤药物使用
公开(公告)号：EP1204649B1
公开(公告)日：2007-10-17
申请号：EP00962760.5
申请日：2000-08-11
申请人： Pfizer Italia S.r.l.
发明人： PEVARELLO, Paolo , AMICI, Raffaella , VILLA, Manuela , SALOM, Barbara , VULPETTI, Anna , VARASI, Mario
IPC分类号： C07D277/46 , C07D417/12 , C07D417/14 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/497 , A61P35/00
CPC分类号： A61K31/426 , C07D277/46
摘要： 2-amino-1,3-thiazole derivatives represented by formula (I) or (II): where R, R1, R2 and R3 are as defined herein, or pharmaceutically acceptable salts thereof, are useful in, for example, the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenertive diseases.
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4.发明授权3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 脲基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202734B1
公开(公告)日：2007-05-02
申请号：EP00955241.5
申请日：2000-08-11
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S.
IPC分类号： A61K31/415 , A61K31/496 , C07D231/40 , C07D403/12
CPC分类号： C07D231/40 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/5377
摘要： 3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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5.发明授权TRICYCLIC PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权三环吡唑衍生物，PROCESS FOR THEIR及其作为抗肿瘤药
公开(公告)号：EP1478357B1
公开(公告)日：2007-01-31
申请号：EP03714744.4
申请日：2003-02-18
申请人： Pfizer Italia S.r.l.
发明人： D'ALESSIO, Roberto , BARGIOTTI, Alberto , BRASCA, Maria, Gabriella , ERMOLI, Antonella , PEVARELLO, Paolo , TIBOLLA, Marcellino
IPC分类号： A61K31/415 , C07D487/04 , A61P25/28 , A61P31/12 , A61P35/00
CPC分类号： C07D403/04 , A61K31/415 , C07D231/54 , C07D403/06 , C07D413/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D495/04
摘要： Compounds which are tricyclic pyrazole derivatives and analogues thereof, as set forth in the specification, or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
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