公开(公告)号：EP3033352A1

公开(公告)日：2016-06-22

申请号：EP14836261.9

申请日：2014-08-14

申请人： RQX Pharmaceuticals, Inc. ,  Genentech, Inc.

发明人： SMITH, Peter, Andrew ,  ROBERTS, Tucker, Curran ,  HIGUCHI, Robert, I. ,  PARASELLI, Prasuna ,  KOEHLER, Michael, F., T. ,  CRAWFORD, James, John

IPC分类号： C07K7/08 ,  A01N37/44 ,  A01N63/00 ,  A61K38/10 ,  A61P31/00

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  Y02A50/401 ,  Y02A50/406 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483

摘要： Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

公开(公告)号：EP3583096A1

公开(公告)日：2019-12-25

申请号：EP18754727.8

申请日：2018-02-22

申请人： RQX Pharmaceuticals, Inc. ,  Genentech, Inc.

发明人： SMITH, Peter, Andrew ,  ROBERTS, Tucker, Curran ,  HIGUCHI, Robert, I. ,  PARASELLI, Prasuna ,  KOEHLER, Michael, F., T. ,  SCHWARZ, Jacob, Bradley ,  CRAWFORD, James, John ,  LY, Cuong Q. ,  HANAN,Emily, J. ,  HU, Huiyong ,  CHEN, Yongsheng ,  YU, Zhiyong ,  WINSHIP, Paul Colin Michael ,  McCLEOD, Calum ,  BLENCH, Toby

IPC分类号： C07D245/04 ,  A61K31/395 ,  A61P31/04

公开(公告)号：EP1629001A2

公开(公告)日：2006-03-01

申请号：EP04776285.1

申请日：2004-06-04

申请人： GENENTECH, INC.

发明人： CHAN, Andrew, Chee-Yuen ,  GORDON, Nathaniel, C. ,  KELLEY, Robert, F. ,  KOEHLER, Michael, F., T. ,  STAROVASNIK, Melissa, A.

IPC分类号： C07K7/00

CPC分类号： A61K39/3955 ,  A61K31/57 ,  A61K31/573 ,  A61K38/00 ,  A61K39/39541 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K7/06 ,  C07K7/08 ,  C07K16/2875 ,  C07K16/2887 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  A61K2300/00

摘要： The present invention relates to polypeptides that block BlyS signaling nucleic acid molecules encoding the polypeptides, and compositions comprising the polypeptides. The present invention also relates to methods for treating an immune-related disease or cancer using the polypeptides and compositions of the invention. The present invention also relates to methods for identifying inhibitors of BlyS signaling .