公开(公告)号：EP2344196B1

公开(公告)日：2018-11-14

申请号：EP09736256.0

申请日：2009-09-11

申请人： University Court of The University of St Andrews

发明人： CONNARIS, Helen ,  TAYLOR, Garry

IPC分类号： G01N33/569 ,  A61P31/04 ,  A61P31/16 ,  A61K31/74

CPC分类号： A61K31/00 ,  A61K31/74 ,  A61P31/04 ,  A61P31/16 ,  G01N33/56911 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2333/115 ,  G01N2333/21 ,  G01N2333/285 ,  G01N2333/315 ,  G01N2400/00 ,  G01N2500/02 ,  Y02A50/471

摘要： The present invention provides compounds, compositions, medicaments and methods comprising or using carbohydrate binding molecules. More specifically, the invention provides a means of treating diseases and/or conditions caused or contributed to by pathogens, particularly microbial pathogens and methods of screening, identifying, detecting tagging and/or labelling carbohydrates.

公开(公告)号：EP2441437B1

公开(公告)日：2018-08-08

申请号：EP10786220.3

申请日：2010-06-10

申请人： Hisamitsu Pharmaceutical Co., Inc.

发明人： TERAHARA Takaaki ,  TOKUMOTO Seiji

IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61M37/00

CPC分类号： A61K9/0021 ,  A61K47/34 ,  A61M37/0015 ,  A61M2037/0023 ,  Y02A50/471

摘要： A coating agent has been applied to microneedles having a biodegradable resin, and a relation between its strength and performance has been clarified. As a result thereof, it has been found that the application of the coating agent to microneedles of a biodegradable resin having a predetermined strength or more, that is, a predetermined weight average molecular weight, allows the microneedles to have excellent performance. Further, it has been found that in regard to the coating agent, a predetermined type and amount thereof are also useful to demonstrate the performance. In view of this, when a microneedle device 1 is arranged so that at least a part of a microneedle array 2 provided with microneedles 3 made from polylactic acid having a weight average molecular weight of 40,000 or more is coated with a carrier containing physiologically active ingredients, it is possible to attain excellent migration characteristics of the physiologically active ingredients to a living body.

公开(公告)号：EP2603514B1

公开(公告)日：2018-07-18

申请号：EP11816882.2

申请日：2011-08-08

申请人： Rempex Pharmaceuticals, Inc.

发明人： HIRST, Gavin ,  REDDY, Raja ,  HECKER, Scott ,  TOTROV, Maxim ,  GRIFFITH, David, C. ,  RODNY, Olga ,  DUDLEY, Michael, N. ,  BOYER, Serge

IPC分类号： C07F5/02 ,  A61K31/69 ,  A61P31/04

CPC分类号： A61K31/69 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/546 ,  A61K45/06 ,  C07F5/025 ,  Y02A50/401 ,  Y02A50/406 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/483 ,  A61K2300/00

摘要： Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.

公开(公告)号：EP2594272B1

公开(公告)日：2018-07-11

申请号：EP12007354.9

申请日：2006-05-18

申请人： Horizon Orphan LLC

发明人： Bostian, Keith A. ,  Dudley, Michael N. ,  Surber, Mark ,  Griffith, David C. ,  Lomovskaya, Olga

IPC分类号： A61K31/5383 ,  A61K31/538 ,  A61K31/4375 ,  A61K31/47 ,  A61K9/12 ,  A61P11/00 ,  A61K9/08 ,  A61K33/06 ,  A61K33/14

CPC分类号： A61K9/0078 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/145 ,  A61K31/5383 ,  A61K33/06 ,  A61K33/14 ,  Y02A50/401 ,  Y02A50/469 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/483 ,  A61K2300/00

摘要： Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.

公开(公告)号：EP1209986B8

公开(公告)日：2018-06-06

申请号：EP00956712

申请日：2000-08-31

申请人： REMEDY RES LIMITED

发明人： HICKOCK STEPHEN SPAULDING

IPC分类号： A23L33/16 ,  A23L1/304 ,  A23L3/358 ,  A61K9/08 ,  A61K31/19 ,  A61K33/02 ,  A61K33/04 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30 ,  A61K33/34 ,  A61K33/42 ,  A61P9/10 ,  A61P11/06 ,  A61P15/00 ,  A61P25/20 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  C02F1/50 ,  C02F1/68 ,  C09D5/14 ,  C09K15/02

CPC分类号： C09D5/14 ,  A01N59/20 ,  A23L3/358 ,  A23L33/165 ,  A61K33/02 ,  A61K33/04 ,  A61K33/06 ,  A61K33/26 ,  A61K33/30 ,  A61K33/34 ,  A61K33/42 ,  C02F1/50 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  A61K33/00 ,  A61K31/19 ,  A61K2300/00 ,  A01N25/02 ,  A01N25/32 ,  A01N37/36 ,  A01N59/02 ,  A01N59/26

摘要： A metal-containing composition substantially comprising (i) at least one water soluble metal compound which forms metal ions when dissolved in water, (ii) at least one metal ion modifier as herein defined, (iii) at least one acid, and (iv) water said composition having a pH of less than 6 and an electrolytic potential in excess of 10 millivolts. Such compositions have uses in the prevention and/or treatment of pathogenic disease or disorder, as foodstuff supplements, in the treatment by disinfection of meat and other foodstuffs, in the coating, sealing and plating of metals, and treatment of water and sewage.

公开(公告)号：EP3288572A1

公开(公告)日：2018-03-07

申请号：EP16786975.9

申请日：2016-04-26

申请人： Albert Einstein College of Medicine, Inc.

发明人： GRAVEKAMP, Claudia

IPC分类号： A61K35/74 ,  C12N15/00 ,  C12R1/01

CPC分类号： A61K39/0011 ,  A61K35/74 ,  A61K39/08 ,  A61K39/39 ,  A61K45/05 ,  A61K2039/5154 ,  A61K2039/522 ,  A61K2039/585 ,  A61P35/04 ,  C07K14/005 ,  C07K14/105 ,  C07K14/12 ,  C07K14/33 ,  C12N1/36 ,  C12N2760/18422 ,  C12N2760/18433 ,  C12N2770/32622 ,  C12N2770/32633 ,  Y02A50/466 ,  Y02A50/471

摘要： Methods, pharmaceutical compositions and vaccines comprising an attenuated bacteria that expresses a recall antigen are disclosed for treatment of cancer.

公开(公告)号：EP1906923B1

公开(公告)日：2018-01-24

申请号：EP06788062.5

申请日：2006-07-21

申请人： The Foundry, LLC

发明人： DEEM, Mark, E. ,  GIFFORD, Hanson, S.

IPC分类号： A61K9/12 ,  A61K39/02 ,  A61K9/08 ,  A61K9/72 ,  A61N1/30 ,  A61K38/16 ,  A61N7/00 ,  A61K38/48 ,  A61K41/00 ,  A61N1/08 ,  A61N1/32

CPC分类号： A61M37/00 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/00434 ,  A61B2018/1861 ,  A61K9/0021 ,  A61K9/0078 ,  A61K38/164 ,  A61K38/168 ,  A61K38/4893 ,  A61K41/00 ,  A61K41/0028 ,  A61K41/0047 ,  A61M37/0092 ,  A61M2210/1035 ,  A61N1/08 ,  A61N1/303 ,  A61N1/327 ,  A61N5/10 ,  A61N7/00 ,  A61N2007/003 ,  C12Y304/24069 ,  Y02A50/471 ,  A61K2300/00

摘要： Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.

公开(公告)号：EP1575558B1

公开(公告)日：2017-11-08

申请号：EP03814501.7

申请日：2003-12-26

申请人： Thorel, Jean-Noël

发明人： THOREL, Jean-Noël ,  GATTO, Hugues

IPC分类号： A61K9/00 ,  A61K45/06 ,  A61K47/02 ,  A61K47/18 ,  A61K31/401 ,  A61K31/728

CPC分类号： A61K9/0014 ,  A61K9/0048 ,  A61K31/401 ,  A61K31/728 ,  A61K45/06 ,  A61K47/02 ,  A61K47/18 ,  Y02A50/471 ,  A61K2300/00

公开(公告)号：EP2471518B1

公开(公告)日：2017-08-23

申请号：EP12162237.7

申请日：2010-05-18

申请人： Sigmoid Pharma Limited

发明人： Coulter, Ivan ,  McDonald, Bernard Francis ,  Aversa, Vincenzo

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/107 ,  A61K38/13 ,  A61K31/436

CPC分类号： A61K38/13 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K9/5026 ,  A61K9/5036 ,  A61K9/5047 ,  A61K9/5073 ,  A61K31/436 ,  A61K38/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  Y02A50/465 ,  Y02A50/471 ,  Y02A50/473

摘要： A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.

公开(公告)号：EP2021022B1

公开(公告)日：2017-04-12

申请号：EP07784000.7

申请日：2007-05-21

申请人： The Foundry, LLC

发明人： DEEM, Mark, E. ,  GIFFORD, Hanson ,  KIM, Steven ,  SALAMINI, Alexey

IPC分类号： A61N7/00 ,  A61N7/02 ,  A61B18/18 ,  A61B18/14 ,  A61K38/48 ,  A61M25/00 ,  A61M25/10 ,  A61M29/02 ,  A61M31/00 ,  A61M35/00 ,  A61N1/32 ,  A61M29/00 ,  A61B17/00 ,  A61N1/05 ,  A61K9/00

CPC分类号： A61M31/00 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00765 ,  A61K9/0043 ,  A61K38/4886 ,  A61K38/4893 ,  A61M25/007 ,  A61M25/0084 ,  A61M25/10 ,  A61M29/00 ,  A61M29/02 ,  A61M35/00 ,  A61M2025/0008 ,  A61M2025/0057 ,  A61M2025/0096 ,  A61M2025/105 ,  A61M2210/0618 ,  A61N1/05 ,  A61N1/0546 ,  A61N1/0568 ,  A61N1/327 ,  A61N7/00 ,  A61N7/022 ,  C12Y304/24069 ,  Y02A50/471

摘要： Apparatus, methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.

摘要翻译： 将毒素和毒素片段输送到患者鼻腔的方法和系统提供毒素的释放和能量的释放，所述能量选择性地对靶细胞进行培养以增强毒素的摄取。 能量介导的递送的使用对于缺乏细胞结合能力的轻链片段毒素是特别有利的。