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1.发明授权VERFAHREN UND VORRICHTUNGEN ZUR ELEKTROCHEMISCHEN BESTIMMUNG VON FAKTOR XA-INHIBITOREN IN BLUTPROBEN 有权方法和设备电化学测定Xa因子抑制剂在血液样本
公开(公告)号：EP2079849B1
公开(公告)日：2013-11-20
申请号：EP07819390.1
申请日：2007-10-27
发明人： HORN, Carina , DOERGE, Liesel , GALM, Margarete
摘要： The determination process involves bringing the blood sample into contact with a detection reagent in which a peptide residue removable by thrombin is amidically linked to an electrogenic substance. The amount or activity of this substance is eliminated from the thrombin substrate by Xa-mediated thrombin activation, producing a measured signal from which the amount or quantity of the factor Xa inhibitor, e.g. a clotting time, is ascertained.
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2.发明公开VERFAHREN UND VORRICHTUNGEN ZUR ELEKTROCHEMISCHEN BESTIMMUNG VON FAKTOR XA-INHIBITOREN IN BLUTPROBEN 有权方法和设备电化学测定Xa因子抑制剂在血液样本
公开(公告)号：EP2079849A1
公开(公告)日：2009-07-22
申请号：EP07819390.1
申请日：2007-10-27
摘要： The invention relates to methods and apparatuses for determining factor Xa inhibitors, especially heparins and fractionated or low molecular weight heparins, and direct FXa inhibitors, in blood samples, which are characterized in that in a first step the blood sample is brought into contact with a detection reagent which comprises at least one thrombin substrate which consists of a peptide residue which can be eliminated by thrombin and which is amidically linked via the carboxyl end to an electrogenic substance, and with a known amount of factor X reagent and an activator reagent which brings about conversion of factor X into factor Xa, subsequently in a second step the amount or activity of the electrogenic substance which is eliminated from the thrombin substrate through the factor Xa-mediated thrombin activation, and/or the time course thereof, is determined as measured signal using electrochemical methods, and finally in a third step, by means of this measured signal, the amount of the factor Xa inhibitor in the sample of the blood to be investigated, or a measured quantity correlating therewith, in particular a clotting time correlating therewith, is ascertained.
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