公开(公告)号：EP3209323B1

公开(公告)日：2024-06-12

申请号：EP15852949.5

申请日：2015-10-23

IPC分类号： A61K38/36 ,  A61P7/00 ,  G01N33/86 ,  G01N33/49 ,  C12Q1/56 ,  C12N9/64 ,  A61K38/48 ,  A61K38/38 ,  A61K38/17 ,  A61K38/00

CPC分类号： C12Q1/56 ,  G01N33/86 ,  A61K38/1703 ,  A61K38/38 ,  A61K38/4806 ,  C12Y304/21006 ,  C12N9/6418 ,  A61K38/36 ,  A61K38/00 ,  A61P7/00

公开(公告)号：EP2747776B1

公开(公告)日：2018-07-11

申请号：EP12758914.1

申请日：2012-08-24

申请人： UMC Utrecht Holding B.V.

发明人： HACK, Cornelis Erik ,  YILDIZ, Cafer

IPC分类号： A61K38/57 ,  A61K38/10 ,  C07K16/38 ,  G01N33/86 ,  A61P7/04

CPC分类号： C07K16/36 ,  A61K38/10 ,  A61K38/57 ,  C07K16/38 ,  C07K2317/76 ,  C12N15/115 ,  C12Q1/56 ,  C12Q1/68 ,  G01N33/86 ,  G01N2333/745 ,  G01N2500/04

摘要： The present invention relates to inhibitors of antithrombin III and the medical use thereof in treating or preventing bleeding. The inhibitors are preferably used in subjects suffering from an acquired or genetic bleeding disorder, such as haemophilia, or in a subjects having a clinical condition characterised by excessive bleeding, such as surgery, trauma and internal bleeding. The inhibitor of antithrombin III can e.g. a peptide, an aptamer or an antibody or antibody fragment that specifically binds to and inhibits antithrombin III.

公开(公告)号：EP3314259A1

公开(公告)日：2018-05-02

申请号：EP16815493.8

申请日：2016-06-27

申请人： T2 Biosystems, Inc.

发明人： DAVISO, Eugenio ,  FOX, Lucius, (Tad) ,  LOWERY, Thomas, Jay Jr. ,  MARTURANO, Joseph ,  PAPKOV, Vyacheslav ,  SCHROFF, Al ,  SMITH, Roger ,  LUO, Zhixiang

IPC分类号： G01N33/53

CPC分类号： G01N24/088 ,  C12Q1/56 ,  G01N24/08 ,  G01N2333/974 ,  G01R33/448

摘要： The invention features a diagnostic platform utilizing T2 magnetic resonance to directly measure integrated reactions in whole blood samples such as clotting, fibrinogen, clot contraction, and fibrinolysis to provide a comprehensive assessment of hemostatic parameters on a single instrument in minutes. The methods of the invention can be performed with less than 1 ml of blood and minimal sample handling.

公开(公告)号：EP2997156B1

公开(公告)日：2018-04-25

申请号：EP14705782.2

申请日：2014-02-21

申请人： Struszym, S.L.

发明人： GALMÉS SUREDA, Bernat ,  CANARO HIRNYK, Mariana Isabel ,  CORTINA GINER, Vicente R.

IPC分类号： C12Q1/56 ,  G01N33/86 ,  B01L3/00

CPC分类号： G01N33/86 ,  B01L3/502 ,  B01L3/5027 ,  B01L2300/024 ,  B01L2300/0825 ,  B01L2300/0838 ,  B01L2300/0864 ,  C12Q1/56 ,  G01N2333/7454

摘要： Test strips for determining the activity of a coagulation factor in a blood sample are provided. The strip comprises a support, a sample inlet port for deposition of a blood sample, and a reaction area comprising a blood coagulation reagent. The sample inlet port is connected to the reaction area, and the coagulation reagent comprises blood plasma deficient in the coagulation factor for which activity is to be measured, an ionic citrate source an ionic calcium source, and either one or more coagulation contact phase activator reagents and phospholipids or a mixture of tissue factor and phospholipids. The disclosure further relates to in vitro methods for measuring an activity of a coagulation factor.

公开(公告)号：EP2619540B1

公开(公告)日：2018-03-21

申请号：EP11826220.3

申请日：2011-09-20

申请人： Q-Sera Pty Ltd

发明人： MASCI, Paul ,  DE JERSEY, John ,  LAVIN, Martin ,  PHILLIPS, Julie ,  DIMESKI, Goce

IPC分类号： G01N1/28 ,  G01N33/50 ,  G01N33/68

CPC分类号： C12Q1/56 ,  G01N33/86

摘要： This invention relates to the use of clotting compositions containing prothrombin activators to produce high quality blood serum samples for pathology and other biological assays, and to containers containing such clotting compositions, and related methods of use.

公开(公告)号：EP3018481B1

公开(公告)日：2018-02-21

申请号：EP15196430.1

申请日：2010-05-20

申请人： Sekisui Medical Co., Ltd.

发明人： MORIKAWA, Chizuru ,  NAKAMURA, Remi ,  YAMAMOTO, Mitsuaki

IPC分类号： G01N33/86 ,  C12Q1/56 ,  A61K31/155 ,  C07C279/14 ,  C07C281/16 ,  C07C279/02

CPC分类号： G01N33/86 ,  A61K31/155 ,  C07C279/02 ,  C07C279/14 ,  C07C281/16 ,  C12Q1/56

摘要： Provided is a reagent, which prolongs a blood coagulation time sufficiently and enhances an optical change, thereby enabling a correct and high-sensitive blood coagulability test. The present invention provides a blood coagulation time prolonging agent, including, as an active ingredient, a guanidine compound represented by the following formula (1) or an acid addition salt thereof (in the formula, R 1 represents a hydrogen atom, an amino group, or an alkyl group which may have a substituent).

公开(公告)号：EP2529221B1

公开(公告)日：2017-12-20

申请号：EP11737503.0

申请日：2011-01-25

申请人： Adventist Health System/Sunbelt Inc.

发明人： FRANCIS, John ,  COLL, Enriqueta ,  AMIRKOSRAVI, Ali

IPC分类号： G01N33/50 ,  C12Q1/56

CPC分类号： C12Q1/56

摘要： A method for measuring a generation of thrombin in a sample of whole blood as a function of time includes adding to a sample of whole blood a fluorogenic substrate and a thrombin activator to form an activated sample. A conversion product is permitted to form in the activated sample. Fluorescence is measured as a function of time from a fluorescent group that is released during the formation of the conversion product with the use of a fluorescence detector. The fluorescence detector operates in an extended range mode and has an increased sensitivity. Thrombin generation as a function of time can then be calculated from the measured fluorescence as a function of time.

公开(公告)号：EP2864496B1

公开(公告)日：2017-11-29

申请号：EP12756826.9

申请日：2012-06-22

申请人： Gentium S.r.l.

发明人： IGNONI, Terenzio ,  KUMAR, Vijay ,  ISLAM, Khalid

IPC分类号： C12Q1/37 ,  C12Q1/56 ,  G01N33/48

CPC分类号： C12N15/11 ,  A61K31/711 ,  C12N2310/127 ,  C12Q1/37 ,  C12Q1/56 ,  G01N33/86

公开(公告)号：EP3209323A1

公开(公告)日：2017-08-30

申请号：EP15852949.5

申请日：2015-10-23

申请人： Q-Sera Pty Ltd

发明人： MASCI, Paul ,  ZHAO, Kong-Nan ,  LAVIN, Martin ,  DE JERSEY, John ,  DIMESKI, Goce

IPC分类号： A61K38/36 ,  A61P7/00 ,  G01N33/86 ,  G01N33/49 ,  C12Q1/56

CPC分类号： A61K38/36 ,  A61K38/00 ,  A61K38/1703 ,  A61K38/38 ,  A61K38/4806 ,  C12N9/6418 ,  C12Q1/56 ,  C12Y304/21006 ,  G01N33/00 ,  G01N33/86 ,  A61K2300/00

摘要： The present invention relates to improved clotting compositions for producing high quality blood serum samples for analyte testing, such as for pathology testing and other biological assays. In particular, the present invention relates to the use of prothrombin activators in combination with stabilizing agents such as colloids for producing high quality blood serum samples. The present invention also relates to associated methods for preparing clotting compositions, tubes, kits and methods of diagnosis, prognosis and monitoring for responsiveness to therapy.

摘要翻译： 本发明涉及用于生产用于分析物测试的高质量血清样品例如用于病理学测试和其他生物测定的改进的凝血组合物。 具体而言，本发明涉及凝血酶原激活剂与稳定剂如胶体组合用于生产高质量血清样品的用途。 本发明还涉及用于制备凝结组合物，试管，试剂盒以及诊断，预后和监测对治疗响应性的方法的相关方法。

公开(公告)号：EP3140650A1

公开(公告)日：2017-03-15

申请号：EP14734284.4

申请日：2014-05-05

申请人： Haemonetics Corporation ,  The Regents of the University of Colorado

发明人： CHAPMAN, Michael P. ,  MOORE, Ernest E. ,  NOREM, Katherine M.

IPC分类号： G01N33/49 ,  G01N33/86

CPC分类号： G01N33/86 ,  C12Q1/56 ,  G01N33/49

摘要： In some embodiments, the invention provides methods for detecting fibrinolysis or hyperfibrinolysis in a blood sample from a patient. The method includes subjecting a first portion of a blood sample comprising reduced platelet function to viscoelastic analysis in the absence of an inhibitor of fibrinolysis to obtain a coagulation characteristic of the first portion at a time point; and subjecting a second portion of the blood sample comprising reduced platelet function to viscoelastic analysis in the presence of an inhibitor of fibrinolysis to obtain a coagulation characteristic of the second portion at the time point; wherein a difference between the coagulation characteristic of the first portion and the coagulation characteristic of the second portion indicates fibrinolysis or hyperfibrinolysis in the blood sample.

摘要翻译： 在一些实施方案中，本发明提供了用于在来自患者的血液样品中检测纤维蛋白溶解或超纤维蛋白溶解的方法。 所述方法包括在不存在纤维蛋白溶解抑制剂的情况下使包含减少血小板功能的血液样品的第一部分进行粘弹性分析，以在时间点获得第一部分的凝结特征; 并且在纤维蛋白溶解抑制剂存在的情况下使包含减少的血小板功能的血液样品的第二部分进行粘弹性分析，以获得在该时间点的第二部分的凝结特征; 其中第一部分的凝固特性与第二部分的凝固特性之间的差异表示血液样品中的纤维蛋白溶解或超纤维蛋白溶解。