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公开(公告)号：EP0960935B1
公开(公告)日：2009-08-05
申请号：EP97954863.3
申请日：1997-02-07
发明人： KISHIMOTO, Tadamitsu , NAGASAWA, Takashi , TACHIBANA, Kazunobu , IIZASA, Hisashi , YOSHIDA, Nobuaki , NAKAJIMA, Toshihiro , YOSHIE, Osamu
IPC分类号： C12N15/12 , C07K14/715 , C12N5/10 , C12P21/02 , C12P21/08 , C07K16/28 , A61K38/18 , A61K38/19 , G01N33/577
CPC分类号： C07K14/7158 , A61K38/00
摘要： A DNA encoding a polypeptide comprising the whole amino acid sequence described in SEQ. ID NO: 17 of the Sequence Listing or a part of the same or a polypeptide containing the above polypeptide which has a receptor activity capable of binding to mouse PBSF/SDF-1; a polypeptide encoded by this DNA and having a receptor activity capable of binding to mouse PBSF/SDF-1; cells expressing this polypeptide and human CD4 protein; and a method for screening an AIDS onset inhibitor, an HIV-1 infection inhibitor, etc. which comprises using the above-mentioned cells. Thus the invention provides a novel mouse CXC chemokine receptor gene which is useful in studies on a remedy for AIDS or the mode of action in the infection with HIV-1, a method for screening an HIV-1 infection inhibitor, etc.
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公开(公告)号：EP0960935A1
公开(公告)日：1999-12-01
申请号：EP97954863.3
申请日：1997-02-07
发明人： KISHIMOTO, Tadamitsu , NAGASAWA, Takashi , TACHIBANA, Kazunobu , IIZASA, Hisashi , YOSHIDA, Nobuaki , NAKAJIMA, Toshihiro , YOSHIE, Osamu
IPC分类号： C12N15/12 , C07K14/715 , C12N5/10 , C12P21/02 , C12P21/08 , C07K16/28 , A61K38/18 , A61K38/19 , G01N33/577
CPC分类号： C07K14/7158 , A61K38/00
摘要： The present invention pertains to a DNA encoding a polypeptide comprising an entire sequence of the amino acid sequence as shown by SEQ ID NO: 17 of Sequence Listing or a partial sequence thereof, or a polypeptide comprising the polypeptide described above, wherein any of the polypeptides has an activity of a receptor capable of binding to a murine PBSF/SDF-1; a polypeptide encoded by the DNA described above, wherein the polypeptide has an activity of a receptor capable of binding to a murine PBSF/SDF-1; cells expressing the polypeptide described above and a human CD4 protein; and a method of screening an AIDS onset inhibitor or an HIV-1 infection inhibitor, characterized by the use of the cells described above. According to the present invention, there can be provided a novel murine CXC chemokine receptor gene, a method of screening an HIV-1 infection inhibitor, and the like, each of which is useful in studies of a therapeutic agent for AIDS and the functional mechanism of HIV-1 infection.
摘要翻译： 本发明涉及编码包含序列表的SEQ ID NO：17所示的氨基酸序列的整个序列或其部分序列的多肽的DNA，或包含上述多肽的多肽，其中任何多肽 具有能够结合小鼠PBSF / SDF-1的受体的活性; 由上述DNA编码的多肽，其中所述多肽具有能够结合小鼠PBSF / SDF-1的受体的活性; 表达上述多肽的细胞和人CD4蛋白; 以及筛选AIDS起始抑制剂或HIV-1感染抑制剂的方法，其特征在于使用上述细胞。 根据本发明，可以提供新的鼠CXC趋化因子受体基因，筛选HIV-1感染抑制剂的方法等，其可用于AIDS治疗剂的研究和功能机制 的HIV-1感染。
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公开(公告)号：EP0860446B1
公开(公告)日：2004-11-17
申请号：EP96932016.7
申请日：1996-09-27
申请人： SHIONOGI & CO., LTD.
IPC分类号： C12N5/10
CPC分类号： C07K14/523 , A61K38/00 , G01N33/6863 , G01N2500/00
摘要： An isolated novel type CC chemokine-like protein which is expressed from monocytes of peripheral blood under an immunological stimulus and has a cell migration activity; a DNA encoding the protein; an expression vector and a transformant containing the DNA; a process for producing a recombinant protein by using the transformant; and a medicinal composition containing the protein.
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公开(公告)号：EP0860446A1
公开(公告)日：1998-08-26
申请号：EP96932016.7
申请日：1996-09-27
申请人： SHIONOGI & CO., LTD.
IPC分类号： C07K14/52 , C12N15/19 , C12N5/10 , C12P21/02 , C07K16/24 , C12P21/08 , G01N33/53 , G01N33/577
CPC分类号： C07K14/523 , A61K38/00 , G01N33/6863 , G01N2500/00
摘要： An isolated novel type CC chemokine-like protein which is expressed from peripheral blood mononuclear cells under an immunological stimulus and has a cell migration activity; a DNA encoding the protein; an expression vector and a transformant containing the DNA; a process for producing a recombinant protein by using the transformant; and a pharmaceutical composition containing the protein.
摘要翻译： 一种分离的新型CC趋化因子样蛋白，其在免疫刺激下由外周血单核细胞表达并具有细胞迁移活性; 编码蛋白质的DNA; 表达载体和含有该DNA的转化体; 通过使用转化体生产重组蛋白的方法; 和含有该蛋白质的药物组合物。
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