公开(公告)号：EP1904851A2

公开(公告)日：2008-04-02

申请号：EP06778519.6

申请日：2006-07-07

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU ,  Glykos Finland Oy

发明人： LAINE, Jarmo ,  JAATINEN, Taina ,  ANDERSON, Heidi ,  NYSTEDT, Johanna ,  TIITINEN, Sari ,  LAITINEN, Anita ,  IMPOLA, Ulla ,  SATOMAA, Tero ,  NATUNEN, Jari ,  HEISKANEN, Annamari ,  BLOMQVIST, Maria ,  OLONEN, Anne

IPC分类号： G01N33/569 ,  C12N5/06

CPC分类号： C12N5/0006 ,  C12N5/0663 ,  G01N33/5073 ,  G01N33/5091 ,  G01N33/56966 ,  G01N2333/91102 ,  G01N2400/38 ,  Y10S436/809

摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.

摘要翻译： 本发明描述存在于人类干细胞上的特定唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其特异性改变的糖基化的新型干细胞。