公开(公告)号：EP2566486A1

公开(公告)日：2013-03-13

申请号：EP11723491.4

申请日：2011-05-06

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU ,  Glykos Finland Oy

发明人： NYSTEDT, Johanna ,  ANDERSON, Heidi ,  SATOMAA, Tero ,  NATUNEN, Jari ,  HELIN, Jari ,  SAARINEN, Juhani

IPC分类号： A61K31/728 ,  C07K14/535 ,  A61P7/00 ,  A61K31/198 ,  C08B37/00

CPC分类号： A61K31/198 ,  A61K31/728 ,  A61K38/193 ,  C07K14/535 ,  C08B37/0072 ,  C08L5/08 ,  A61K2300/00

摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention relates also to a use of the combination to alter the relative amounts of blood cells and/or the types of blood cells in a subject. Further, the present invention relates to a use of the combination to mobilize stem cells to the bloodstream of a subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.

公开(公告)号：EP2316028A1

公开(公告)日：2011-05-04

申请号：EP09797547.8

申请日：2009-07-16

申请人： Suomen Punainen Risti, Veripalvelu ,  Glykos Finland Oy

发明人： HIRVONEN, Tia ,  KOTOVUORI, Annika ,  PITKÄNEN, Virve ,  NATUNEN, Suvi ,  NYSTEDT, Johanna ,  TIITINEN, Sari ,  VALMU, Leena ,  NATUNEN, Jari

IPC分类号： G01N33/53 ,  G01N33/563 ,  G01N33/577 ,  C07H13/00

CPC分类号： G01N33/5308 ,  G01N33/56966 ,  G01N2400/12 ,  G01N2400/38

摘要： The invention describes novel reagents that can be applied for analysis of the quality of human cells. The method evaluates the integrity of the plasma membrane of the cells by detecting novel glyco structures found only intracellularly. The method can be applied, for example, to demonstrate exposure of therapeutic cell preparation to potentially harmful conditions. It can also be used as a quality control tool in methods in which intact cell membrane is essential and it can be applied in separation of damaged cells from non- damaged.

公开(公告)号：EP1904851A2

公开(公告)日：2008-04-02

申请号：EP06778519.6

申请日：2006-07-07

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU ,  Glykos Finland Oy

发明人： LAINE, Jarmo ,  JAATINEN, Taina ,  ANDERSON, Heidi ,  NYSTEDT, Johanna ,  TIITINEN, Sari ,  LAITINEN, Anita ,  IMPOLA, Ulla ,  SATOMAA, Tero ,  NATUNEN, Jari ,  HEISKANEN, Annamari ,  BLOMQVIST, Maria ,  OLONEN, Anne

IPC分类号： G01N33/569 ,  C12N5/06

CPC分类号： C12N5/0006 ,  C12N5/0663 ,  G01N33/5073 ,  G01N33/5091 ,  G01N33/56966 ,  G01N2333/91102 ,  G01N2400/38 ,  Y10S436/809

摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.

摘要翻译： 本发明描述存在于人类干细胞上的特定唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其特异性改变的糖基化的新型干细胞。

公开(公告)号：EP2556144A1

公开(公告)日：2013-02-13

申请号：EP11719588.3

申请日：2011-04-06

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU

发明人： NYSTEDT, Johanna ,  HAKKARAINEN, Tanja ,  LEHENKARI, Petri ,  KERKELÄ, Erja ,  VALMU, Leena

IPC分类号： C12N5/00

CPC分类号： C12N5/0665 ,  A61K35/12 ,  C12N5/0006 ,  C12N5/0663 ,  C12N2501/734 ,  C12N2509/00

摘要： The present invention relates to a stem cell and/or a population thereof having a specific profile of cell surface proteins and/or proteoglycans. The present invention also relates to use of a proteolytic enzyme in the modification of the cell surface of a stem cell. The present invention further relates to a method of modifying the cell surface of a stem cell by treatment with a proteolytic enzyme.

摘要翻译： 本发明涉及具有细胞表面蛋白和/或蛋白聚糖特异性特征的干细胞和/或其群体。 本发明还涉及蛋白水解酶在干细胞的细胞表面的修饰中的用途。 本发明还涉及通过用蛋白水解酶处理来修饰干细胞的细胞表面的方法。

公开(公告)号：EP2118273A1

公开(公告)日：2009-11-18

申请号：EP08701715.8

申请日：2008-01-18

申请人： Suomen Punainen Risti, Veripalvelu ,  Glykos Finland Ltd

发明人： LAINE, Jarmo ,  SATOMAA, Tero ,  NATUNEN, Jari ,  JAATINEN, Taina ,  HEISKANEN, Annamari ,  NYSTEDT, Johanna

IPC分类号： C12N5/08 ,  C12Q1/48 ,  C12N9/10 ,  C12N9/24 ,  G01N33/50 ,  C08B37/00

CPC分类号： C12N5/0663 ,  C08B37/00 ,  C12N5/0006 ,  C12N5/0665 ,  C12N9/1051 ,  C12N9/1081 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/39 ,  C12N2501/70 ,  C12N2501/90 ,  C12N2502/13 ,  C12Q1/48 ,  G01N33/6842

摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by changing sialylation and/or fucosylation levels of the cells. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered. The control methods are preferably mass spectrometric methods.

公开(公告)号：EP2318540A1

公开(公告)日：2011-05-11

申请号：EP09797548.6

申请日：2009-07-16

申请人： Suomen Punainen Risti, Veripalvelu ,  Glykos Finland Ltd

发明人： NYSTEDT, Johanna ,  ANDERSON, Heidi ,  VALMU, Leena ,  NATUNEN, Jari ,  SATOMAA, Tero

IPC分类号： C12Q1/48 ,  G01N33/50 ,  C12N9/10 ,  C12N9/24

CPC分类号： C12N5/0006 ,  A61K2035/124 ,  C12N5/0663 ,  C12N5/0665 ,  C12N9/1051 ,  C12N2501/70 ,  C12N2501/724 ,  C12P21/005

摘要： The invention is directed to a method and kit to control and modify the status of cells, such as human stem cells, by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where culture medium reagents, such as divalent cations, are present and cells are kept non-adherent. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.

公开(公告)号：EP2764092A1

公开(公告)日：2014-08-13

申请号：EP12837914.6

申请日：2012-10-04

申请人： Glykos Finland Oy

发明人： KERKELÄ, Erja ,  HAKKARAINEN, Tanja ,  NYSTEDT, Johanna ,  PARTANEN, Jukka

IPC分类号： C12N5/0789

CPC分类号： A61K35/28 ,  C12N5/0006 ,  C12N5/0647 ,  C12N2501/734

摘要： The present invention relates to a hematopoietic stem cell and/or a population thereof having a specific profile of cell surface proteins and/or proteoglycans. The present invention also relates to use of proteolytic enzymes, such as pronase and pronase-like enzymes in the modification of the cell surface of a hematopoietic stem cell. The present invention further relates to a method of modifying the cell surface of a hematopoietic stem cell by treatment with proteolytic enzymes, such as pronase and pronase-like enzymes.