公开(公告)号：EP2356111A1

公开(公告)日：2011-08-17

申请号：EP09752069.6

申请日：2009-11-09

申请人： Schering Corporation

发明人： KOZLOWSKI, Joseph, A. ,  YU, Wensheng ,  WONG, Michael, K.C. ,  KIM, Seong-Heon ,  TONG, Ling ,  LAVEY, Brian, J. ,  SHANKAR, Bandarpalle, B. ,  YANG, De-Yi ,  FELTZ, Robert ,  KOSINSKI, Aneta, Maria ,  ZHOU, Guowei ,  RIZVI, Razia, K. ,  DAI, Chaoyang ,  FIRE, Luke ,  GIRIJAVALLABHAN, Vinay, M. ,  LI, Dansu ,  POPOVICI-MULLER, Janeta ,  RICHARD, Judson, E. ,  ROSNER, Kristin, E. ,  SIDDIQUI, M., Arshad ,  YANG, Liping

IPC分类号： C07D403/14 ,  A61P29/00 ,  A61K31/4178

CPC分类号： C07D403/14

摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

公开(公告)号：EP1976849A2

公开(公告)日：2008-10-08

申请号：EP07709799.6

申请日：2007-01-16

申请人： Schering Corporation

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Guowei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K.C. ,  YANG, De-Yi ,  KIM, Seong-Heon ,  SHANKAR, Bandarpalle, B. ,  SIDDIQUI, M., Arshad ,  ROSNER, Kristin, E. ,  DAI, Chaoyang ,  POPOVICI-MULLER, Janeta ,  GIRIJAVALLABHAN, Vinay, M. ,  LI, Dansu ,  RIZVI, Razia ,  MICULA, Aneta, S ,  FELTZ, Robert

IPC分类号： C07D401/14 ,  C07D403/06 ,  A61P35/00 ,  A61K31/4166 ,  C07D471/04 ,  C07D473/34 ,  C07D473/00 ,  C07D491/04 ,  C07D495/04 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14

CPC分类号： C07D403/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

摘要翻译： 本发明涉及可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或其组合介导的疾病或病症的式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体 。

公开(公告)号：EP2355825A2

公开(公告)日：2011-08-17

申请号：EP09752068.8

申请日：2009-11-09

申请人： Schering Corporation

发明人： TONG, Ling ,  LAVEY, Brian, J. ,  SHANKAR, Bandarpalle, B. ,  KIM, Seong-Heon ,  YU, Wensheng ,  KOZLOWSKI, Joseph, A. ,  WONG, Michael, K.C. ,  CHEN, Lei ,  ZHOU, Guowei ,  RIZVI, Razia, K. ,  FELTZ, Robert ,  KOSINSKI, Aneta, Maria ,  YANG, De-Yi ,  DAI, Chaoyang ,  FIRE, Luke ,  GIRIJAVALLABHAN, Vinay, M. ,  LI, Dansu ,  POPOVICI-MULLER, Janeta ,  RICHARD, Judson, E. ,  ROSNER, Kristin, E. ,  SIDDIQUI, M., Arshad ,  YANG, Liping

IPC分类号： A61K31/4741

CPC分类号： C07D498/04 ,  C07D513/00 ,  C07D519/00

摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

摘要翻译： 本发明涉及式（I）的化合物：（化学式应插入此处，如出现在纸上的摘要中）（I）或其药学上可接受的盐，其可用于治疗介导的疾病或病症 由MMPs，ADAMs，TACE，聚集蛋白聚糖酶，TNF-或其组合。