公开(公告)号：EP2331528A2

公开(公告)日：2011-06-15

申请号：EP09792830.3

申请日：2009-09-22

申请人： Schering Corporation

发明人： SHANKAR, Bandarpalle, B. ,  KIM, Seong, Heon ,  YU, Wensheng ,  TONG, Ling ,  WONG, Michael, K. C. ,  LAVEY, Brian J. ,  KOZLOWSKI, Joseph, A. ,  CHEN, Lei ,  RIZVI, Razia, K. ,  KOSINSKI, Aneta, Maria ,  YANG, De-Yi ,  ZHOU, Guowei ,  ROSNER, Kristen, E. ,  FIRE, Luke ,  RICHARD, Judson, E. ,  LI, Dansu

IPC分类号： C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D491/048 ,  A61K31/33 ,  A61P19/00

摘要： This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

摘要翻译： 本发明涉及本文所述的式（I）化合物或其药学上可接受的盐，溶剂合物或酯，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-或介导的疾病或病症 其组合。

公开(公告)号：EP2346857A2

公开(公告)日：2011-07-27

申请号：EP09792832.9

申请日：2009-09-22

申请人： Schering Corporation

发明人： WONG, Michael, K., C. ,  YU, Wensheng ,  TONG, Ling ,  LAVEY, Brian, J. ,  SHANKAR, Bandarpalle, B. ,  KOZLOWSKI, Joseph, A. ,  KIM, Seong, Heon ,  ZHOU, Guowei ,  YANG, De-Yi ,  RIZVI, Razia, K. ,  CHEN, Lei ,  KOSINSKI, Aneta, Maria ,  ROSNER, Kristen, E. ,  FIRE, Luke ,  RICHARD, Judson, E. ,  LI, Dansu

IPC分类号： C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D491/048 ,  A61K31/33 ,  A61P19/00

CPC分类号： C07D405/14 ,  C07D403/06 ,  C07D403/14 ,  C07D491/048

摘要： This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-alpha combinations thereof.

公开(公告)号：EP1976849A2

公开(公告)日：2008-10-08

申请号：EP07709799.6

申请日：2007-01-16

申请人： Schering Corporation

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Guowei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K.C. ,  YANG, De-Yi ,  KIM, Seong-Heon ,  SHANKAR, Bandarpalle, B. ,  SIDDIQUI, M., Arshad ,  ROSNER, Kristin, E. ,  DAI, Chaoyang ,  POPOVICI-MULLER, Janeta ,  GIRIJAVALLABHAN, Vinay, M. ,  LI, Dansu ,  RIZVI, Razia ,  MICULA, Aneta, S ,  FELTZ, Robert

IPC分类号： C07D401/14 ,  C07D403/06 ,  A61P35/00 ,  A61K31/4166 ,  C07D471/04 ,  C07D473/34 ,  C07D473/00 ,  C07D491/04 ,  C07D495/04 ,  C07D417/14 ,  C07D413/14 ,  C07D405/14 ,  C07D403/14

CPC分类号： C07D403/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

摘要翻译： 本发明涉及可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或其组合介导的疾病或病症的式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体 。

公开(公告)号：EP1778676A1

公开(公告)日：2007-05-02

申请号：EP05771446.1

申请日：2005-07-13

申请人： SCHERING CORPORATION

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Gouwei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K. C. ,  YANG, De-Yi ,  KIM, Seong, Heon ,  SHANKAR, Bandarpalle

IPC分类号： C07D403/06 ,  C07D417/14 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  A61P43/00 ,  A61P29/00 ,  A61K31/4178

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.

公开(公告)号：EP2356111A1

公开(公告)日：2011-08-17

申请号：EP09752069.6

申请日：2009-11-09

申请人： Schering Corporation

发明人： KOZLOWSKI, Joseph, A. ,  YU, Wensheng ,  WONG, Michael, K.C. ,  KIM, Seong-Heon ,  TONG, Ling ,  LAVEY, Brian, J. ,  SHANKAR, Bandarpalle, B. ,  YANG, De-Yi ,  FELTZ, Robert ,  KOSINSKI, Aneta, Maria ,  ZHOU, Guowei ,  RIZVI, Razia, K. ,  DAI, Chaoyang ,  FIRE, Luke ,  GIRIJAVALLABHAN, Vinay, M. ,  LI, Dansu ,  POPOVICI-MULLER, Janeta ,  RICHARD, Judson, E. ,  ROSNER, Kristin, E. ,  SIDDIQUI, M., Arshad ,  YANG, Liping

IPC分类号： C07D403/14 ,  A61P29/00 ,  A61K31/4178

CPC分类号： C07D403/14

摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

公开(公告)号：EP2350020A1

公开(公告)日：2011-08-03

申请号：EP09741076.5

申请日：2009-09-30

申请人： Schering Corporation

发明人： STAMFORD, Andrew ,  MILLER, Michael, W. ,  DEMONG, Duane, Eugene ,  GREENLEE, William, J. ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  WONG, Michael, K.C. ,  YU, Wensheng ,  DAI, Xing ,  YANG, De-Yi ,  ZHOU, Guowei

IPC分类号： C07D235/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D491/10 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/47

CPC分类号： C07D235/02 ,  A61K31/4184 ,  A61K45/06 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D491/10 ,  A61K2300/00

摘要： The present invention relates to compounds of the general formula: (I) wherein ring A, ring B, R
1 , R
3 , Z, L
1 , and L
2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.

公开(公告)号：EP1858888A2

公开(公告)日：2007-11-28

申请号：EP06758146.2

申请日：2006-02-14

申请人： Schering Corporation ,  PHARMACOPEIA, INC.

发明人： ZENG, Qingbei ,  YANG, De-Yi ,  ROSENBLUM, Stuart, B. ,  WONG, Michael, K.C. ,  ANILKUMAR, Gopinadhan, N. ,  KIM, Seong, Heon ,  YU, Wensheng ,  KOZLOWSKI, Joseph, A. ,  SHIH, Neng-Yang ,  MCGUINNESS, Brian, F. ,  ZAWACKI, Lisa, Guise ,  HOBBS, Douglas, W.

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  A61K31/445 ,  A61K31/495 ,  C07D417/14 ,  C07D487/04

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure shown in Formula 1 and the pharmaceutically acceptable salts, solvates or esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non limiting example(s) include, psoriasis), autoimmune diseases (non limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.

公开(公告)号：EP2355825A2

公开(公告)日：2011-08-17

申请号：EP09752068.8

申请日：2009-11-09

申请人： Schering Corporation

发明人： TONG, Ling ,  LAVEY, Brian, J. ,  SHANKAR, Bandarpalle, B. ,  KIM, Seong-Heon ,  YU, Wensheng ,  KOZLOWSKI, Joseph, A. ,  WONG, Michael, K.C. ,  CHEN, Lei ,  ZHOU, Guowei ,  RIZVI, Razia, K. ,  FELTZ, Robert ,  KOSINSKI, Aneta, Maria ,  YANG, De-Yi ,  DAI, Chaoyang ,  FIRE, Luke ,  GIRIJAVALLABHAN, Vinay, M. ,  LI, Dansu ,  POPOVICI-MULLER, Janeta ,  RICHARD, Judson, E. ,  ROSNER, Kristin, E. ,  SIDDIQUI, M., Arshad ,  YANG, Liping

IPC分类号： A61K31/4741

CPC分类号： C07D498/04 ,  C07D513/00 ,  C07D519/00

摘要： This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

摘要翻译： 本发明涉及式（I）的化合物：（化学式应插入此处，如出现在纸上的摘要中）（I）或其药学上可接受的盐，其可用于治疗介导的疾病或病症 由MMPs，ADAMs，TACE，聚集蛋白聚糖酶，TNF-或其组合。

公开(公告)号：EP1778676B1

公开(公告)日：2010-08-25

申请号：EP05771446.1

申请日：2005-07-13

申请人： Schering Corporation

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Guowei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K. C. ,  YANG, De-Yi ,  KIM, Seong, Heon ,  SHANKAR, Bandarpalle

IPC分类号： C07D403/06 ,  C07D417/14 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  A61P43/00 ,  A61P29/00 ,  A61K31/4178

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.