公开(公告)号：EP2035416A1

公开(公告)日：2009-03-18

申请号：EP07796521.8

申请日：2007-06-27

申请人： Schering Corporation ,  Albany Molecular Research, Inc.

发明人： MA, Yao ,  LAHUE, Brian, R. ,  SHIPPS, JR., Gerald, W. ,  WANG, Yaolin ,  BOGEN, Stephane, L. ,  VOSS, Matthew. E. ,  NAIR, Latha, G. ,  TIAN, Yuan ,  DOLL, Ronald, J. ,  GUO, Zhuyan ,  STRICKLAND, Corey, O. ,  ZHANG, Rumin ,  MCCOY, Mark, A. ,  PAN, Weidong ,  SIEGEL, Elise, M. ,  GIBEAU, Craig, R.

IPC分类号： C07D409/14 ,  C07D401/06 ,  C07D401/14 ,  A61P35/00 ,  A61K31/496 ,  A61K31/506

CPC分类号： C07D409/14 ,  C07D401/06 ,  C07D401/14

摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

公开(公告)号：EP2358716A1

公开(公告)日：2011-08-24

申请号：EP09752650.3

申请日：2009-11-10

申请人： Schering Corporation

发明人： SHIPPS, JR., Gerald, W. ,  CHENG, Cliff, C. ,  HUANG, Xiaohua ,  ACHAB, Abdelghani, Abe ,  ORTH, Peter ,  VOIGT, Johannes, H. ,  SOUCY, Kyle, Ann

IPC分类号： C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D519/00

摘要： The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein ("FABP") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the present invention is shown below: (I)