公开(公告)号：EP2035416A1

公开(公告)日：2009-03-18

申请号：EP07796521.8

申请日：2007-06-27

申请人： Schering Corporation ,  Albany Molecular Research, Inc.

发明人： MA, Yao ,  LAHUE, Brian, R. ,  SHIPPS, JR., Gerald, W. ,  WANG, Yaolin ,  BOGEN, Stephane, L. ,  VOSS, Matthew. E. ,  NAIR, Latha, G. ,  TIAN, Yuan ,  DOLL, Ronald, J. ,  GUO, Zhuyan ,  STRICKLAND, Corey, O. ,  ZHANG, Rumin ,  MCCOY, Mark, A. ,  PAN, Weidong ,  SIEGEL, Elise, M. ,  GIBEAU, Craig, R.

IPC分类号： C07D409/14 ,  C07D401/06 ,  C07D401/14 ,  A61P35/00 ,  A61K31/496 ,  A61K31/506

CPC分类号： C07D409/14 ,  C07D401/06 ,  C07D401/14

摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.

公开(公告)号：EP2037919A2

公开(公告)日：2009-03-25

申请号：EP07796519.2

申请日：2007-06-27

申请人： Schering Corporation

发明人： WANG, Yaolin ,  ZHANG, Rumin ,  MA, Yao ,  LAHUE, Brian, R. ,  SHIPPS, Gerald, W., Jr.

IPC分类号： A61K31/45 ,  A61K31/454 ,  A61K31/4545 ,  A61P35/00

CPC分类号： A61K31/45 ,  A61K31/454 ,  A61K31/4545

摘要： The present invention discloses a method of using compounds, which have HDM2 protein antagonist activity, to treat or prevent cancer, other diseases caused by abnormal cell proliferation, diseases associated with HDM2, or diseases caused by inadequate P53 activity.