公开(公告)号：EP4428535A1

公开(公告)日：2024-09-11

申请号：EP23382220.4

申请日：2023-03-09

申请人： Servizo Galego de Saude ,  Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS) ,  Universidade de Santiago de Compostela

发明人： ALONSO SAMPEDRO, Manuela ,  GONZÁLEZ QUÍNTELA, Arturo ,  GUDE SAMPEDRO, Francisco

IPC分类号： G01N33/68

CPC分类号： G01N2800/04220130101 ,  G01N33/6893 ,  G01N2333/7820130101 ,  G01N2333/472820130101 ,  G01N2800/5220130101 ,  G01N2333/471620130101 ,  G01N2800/5020130101

摘要： The present invention refers to an in vitro method for the diagnosis, monitoring or prognosis of diabetes or prediabetes; or for screening or selecting patient candidates to be subjected to OGTT, which comprises assessing the percentage of a protein, selected from the group consisting of: Retinol-Binding Protein 4 (Rbp), Alpha-1-acid glycoprotein (Agp) and/or fibronectin (FN), which is bound to glycosaminoglycans (GAGs).

公开(公告)号：EP3349007A1

公开(公告)日：2018-07-18

申请号：EP16843721.8

申请日：2016-09-09

申请人： Universidade de Santiago de Compostela ,  Servizo Galego De Saúde (Sergas) ,  FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA

发明人： ALONSO SAMPEDRO, Manuela ,  ÁLVAREZ GONZÁLEZ, Víctor ,  COLÓN MEJERAS, Cristóbal ,  GARCÍA GONZÁLEZ, Miguel A. ,  LAMAS GONZÁLEZ, Olaya

IPC分类号： G01N33/53

CPC分类号： G01N33/6839 ,  G01N33/5091 ,  G01N33/53 ,  G01N33/585 ,  G01N2400/40 ,  G01N2800/04 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention is comprised in the field of glycobiology. In particular, it relates to a method for separating, in biological samples, the fraction bound to or associated with sulfated glycosaminoglycans (GAGs), and the applications thereof in biomedicine, such as for identifying the profile of glycoproteins or the profile of lipids bound to or associated with sulfated GAGs, detecting an alteration in the pattern of glycosylation by sulfated GAGs, identifying biomarkers for the diagnosis, for the prognosis, for monitoring the progression of a disease or of the effect of a therapy, or for identifying compounds suitable for the treatment of a disease. The invention also relates to methods for diagnosing mucopolysaccharidosis and for diagnosing and determining the prognosis of a kidney disease.