公开(公告)号：EP3411713A1

公开(公告)日：2018-12-12

申请号：EP17709500.7

申请日：2017-02-03

申请人： Nanoview Diagnostics Inc.

发明人： DAABOUL, George ,  FREEDMAN, David S.

IPC分类号： G01N33/543 ,  G01N21/47 ,  G01N33/574

CPC分类号： G01N33/57438 ,  G01N21/253 ,  G01N21/45 ,  G01N21/47 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2201/062 ,  G01N2400/40

摘要： A spectral reflectance imaging device for detecting nanoparticle exosome biomarker targets includes an illumination source that illuminates a substrate with a plurality of separate wavelengths of incoherent light. The substrate includes an oxide layer and a binding agent to selectively bind nanoparticle exosome biomarker targets to the substrate. An imaging device bindings the light reflected from or transmitted through the substrate and an image processing system detects the nanoparticle exosome biomarker targets a function of the change in reflective properties of the substrate.

公开(公告)号：EP3349007A1

公开(公告)日：2018-07-18

申请号：EP16843721.8

申请日：2016-09-09

申请人： Universidade de Santiago de Compostela ,  Servizo Galego De Saúde (Sergas) ,  FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA

发明人： ALONSO SAMPEDRO, Manuela ,  ÁLVAREZ GONZÁLEZ, Víctor ,  COLÓN MEJERAS, Cristóbal ,  GARCÍA GONZÁLEZ, Miguel A. ,  LAMAS GONZÁLEZ, Olaya

IPC分类号： G01N33/53

CPC分类号： G01N33/6839 ,  G01N33/5091 ,  G01N33/53 ,  G01N33/585 ,  G01N2400/40 ,  G01N2800/04 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention is comprised in the field of glycobiology. In particular, it relates to a method for separating, in biological samples, the fraction bound to or associated with sulfated glycosaminoglycans (GAGs), and the applications thereof in biomedicine, such as for identifying the profile of glycoproteins or the profile of lipids bound to or associated with sulfated GAGs, detecting an alteration in the pattern of glycosylation by sulfated GAGs, identifying biomarkers for the diagnosis, for the prognosis, for monitoring the progression of a disease or of the effect of a therapy, or for identifying compounds suitable for the treatment of a disease. The invention also relates to methods for diagnosing mucopolysaccharidosis and for diagnosing and determining the prognosis of a kidney disease.

公开(公告)号：EP3303402A2

公开(公告)日：2018-04-11

申请号：EP16800793.8

申请日：2016-05-27

申请人： La Jolla Biologics, Inc. ,  Tanvex Biologics Corp.

发明人： LEE, Yu-ching ,  YANG, Yi-Yuan ,  YEN, Yun

IPC分类号： C07K16/30 ,  A61K39/395 ,  G01N33/68 ,  A61K38/45 ,  G01N33/574 ,  A61K39/00

CPC分类号： C07K16/303 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/02 ,  C07K2317/24 ,  C07K2317/622 ,  G01N33/57407 ,  G01N33/57438 ,  G01N2400/40 ,  G01N2800/085

摘要： The present invention relates to anti-GPC3 antibodies and their applications. The invention investigates the potential inhibitory effect of anti-GPC3 antibodies on tumor growth, proliferation, migration and their applications for diagnostic and therapeutic purposes.

公开(公告)号：EP3131655A4

公开(公告)日：2018-02-14

申请号：EP14889100

申请日：2014-12-05

申请人： MEP EQUINE SOLUTIONS LLC

发明人： SLUSAREWICZ PAWEL ,  HAUCK ERIC W

IPC分类号： B01D35/00 ,  C12Q1/24 ,  G01N33/53

CPC分类号： G01N33/56905 ,  G01N33/5308 ,  G01N2333/43526 ,  G01N2333/44 ,  G01N2400/40

摘要： Method and kits are provided determining the presence or absence of parasitic helminth eggs in environmental samples, particularly fecal samples. The methods incorporate egg capture methods and the use of N-acetyl-D-glucosamine specific ligands for egg detection.

公开(公告)号：EP3219795A1

公开(公告)日：2017-09-20

申请号：EP16203748.5

申请日：2009-01-16

申请人： BioMarin Pharmaceutical Inc.

发明人： VELLARD, Michel Claude ,  KOPPAKA, Vish ,  DVORAK-EWELL, Melita ,  PUNGNOR, Erno ,  HAGUE, Charles

IPC分类号： C12N9/16 ,  C12P21/00 ,  A61K38/46

CPC分类号： C12N9/16 ,  A01K2217/075 ,  A01K2267/035 ,  A61K38/00 ,  C12Q1/34 ,  C12Q1/44 ,  C12Y301/06014 ,  G01N33/6893 ,  G01N2333/924 ,  G01N2400/40 ,  G01N2500/04 ,  G01N2800/04

摘要： This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.

摘要翻译： 本发明提供了活性高度磷酸化溶酶体硫酸酯酶的组合物，它们的药物组合物，生产和纯化这种溶酶体硫酸酯酶和组合物的方法以及它们在诊断，预防或治疗疾病和病症中的用途，特别包括溶酶体贮积病 由溶酶体硫酸酯酶缺陷引起或与之相关。

公开(公告)号：EP3218722A1

公开(公告)日：2017-09-20

申请号：EP15802276.4

申请日：2015-11-13

申请人： Shire Human Genetic Therapies, Inc.

发明人： NAIMY, Hicham ,  QIU, Yongchang ,  HASLETT, Patrick Anthony John ,  BARBIER, Ann

IPC分类号： G01N33/68 ,  C12Q1/34

CPC分类号： G01N33/6848 ,  C12Q1/34 ,  G01N33/6893 ,  G01N2400/40 ,  G01N2560/00 ,  G01N2800/042 ,  G01N2800/52

摘要： Detecting glycosaminoglycans (GAGs) and/or determining the level of one or more glycosaminoglycans can be useful, e.g., in identifying or monitoring various medical conditions, the status of patients having various medical conditions, and/or the response to treatment of individuals having various medical conditions. The present invention provides methods for detecting glycosaminoglycans and/or determining the level of glycosaminoglycans through the use of, e.g., mass spectrometry.

摘要翻译： 检测糖胺聚糖（GAG）和/或确定一种或多种糖胺聚糖的水平可用于例如识别或监测各种医疗状况，患有各种医疗状况的患者的状态和/或对具有各种 医疗条件。 本发明提供了通过使用例如质谱法检测糖胺聚糖和/或确定糖胺聚糖水平的方法。

公开(公告)号：EP2409154B1

公开(公告)日：2017-08-02

申请号：EP10712036.2

申请日：2010-03-18

申请人： UNIVERSITE D'ANGERS ,  Centre Hospitalier Universitaire d'Angers

发明人： CALES, Paul

IPC分类号： G01N33/574 ,  G01N33/576 ,  G01N33/68

CPC分类号： G06F19/12 ,  A61K31/00 ,  A61K38/21 ,  G01N33/50 ,  G01N33/57438 ,  G01N33/576 ,  G01N33/6893 ,  G01N2333/4713 ,  G01N2333/495 ,  G01N2333/78 ,  G01N2400/40 ,  G01N2800/085 ,  G01N2800/52 ,  G01N2800/60 ,  G01N2800/7052 ,  G06F19/00

摘要： A method for implementing an adapted patient care for an individual suffering from liver fibrosis after assessing liver fibrosis progression in the individual, and thus determining whether the individual is a slow, medium or fast fibroser. Also, a method for treating an individual suffering from liver fibrosis and identified as a fast fibroser, which includes the steps of identifying the individual as a fast fibroser by assessing fibrosis progression and treating the individual by administering without delay at least one therapeutic agent for treating liver fibrosis, or for treating the underlying cause responsible for liver fibrosis, or both.

摘要翻译： 本发明涉及评估个体肝纤维化进展的非侵入性方法，所述方法包括计算纤维化水平与造成持续时间的比率和评估个体肝纤维化进展的非侵入性方法的步骤， 所述方法包括以下步骤：在两个不同的时间t1和t2测量纤维化水平FL（t1）和FL（t2），并计算比值FL（t2）-FL（t1）到（t2-t1） 非侵入性评估个体是否为慢，中等或快速纤维化的方法。

公开(公告)号：EP3032256A4

公开(公告)日：2017-03-22

申请号：EP14834659

申请日：2014-08-04

申请人： DAIICHI SANKYO CO LTD

发明人： MATSUURA TOMOKAZU ,  AMANO KATSUSHI ,  SUGITA TOMONORI ,  MASUBUCHI NORIKO ,  SUGIHARA MASAHIRO

IPC分类号： G01N33/50 ,  G01N33/487

CPC分类号： G01N33/487 ,  G01N33/50 ,  G01N33/5308 ,  G01N2400/40 ,  G01N2800/085 ,  G01N2800/52 ,  H01J49/0036

摘要： Provided is a test method for discriminating a liver injury type using as an indicator a level of lithocholic acid (hereinafter abbreviated as LCA) in a biological sample of a subject. That is, provided is a test method comprising measuring a level of LCA in a biological sample collected from a subject, and discriminating a liver injury type as hepatocellular injury type, cholestasis type, or a mixed type thereof using the measured level of LCA as an indicator.

公开(公告)号：EP3101426A3

公开(公告)日：2017-02-08

申请号：EP16173307.6

申请日：2011-12-16

申请人： National Institute of Advanced Industrial Science and Technology

发明人： NARIMATSU, Hisashi ,  HIRABAYASHI, Jun ,  KUNO, Atsushi ,  MATSUZAKI, Hideki ,  IKEHARA, Yuzuru ,  ITO, Hiromi ,  HASHIMOTO, Yasuhiro ,  SHIROTANI, Keiro ,  FUTAKAWA, Satoshi ,  ARAI, Hajime ,  MIYAJIMA, Masakazu ,  FUJIHARA, Kazuo

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N33/6842 ,  G01N2333/47 ,  G01N2333/4728 ,  G01N2400/40 ,  G01N2800/285 ,  H01J49/0036

摘要： The purpose of the present invention is to develop: a method for selectively separating a glycoprotein derived from the central nervous system from a body fluid or a central nervous system cell; and a method for searching for an index marker for central nervous system diseases, which utilizes the aforementioned method. A protein derived from the central nervous system, which occurs in a trace amount in a body fluid or a central nervous system cell, can be selectively enriched by a two-stage separation procedure comprising removing a glycoprotein having sialic acid at a non-reducing terminal thereof from the body fluid or the central nervous system cell and then separating a glycoprotein having N-acetylglucosamine at a non-reducing terminal thereof.

摘要翻译： 本发明的目的是开发：一种方法，用于选择性地分离从体液或中枢神经系统细胞中枢神经系统衍生的糖蛋白; 并在indexmarker用于中枢神经系统疾病，其利用上述方法搜索的方法。 从中枢神经系统衍生的蛋白质，其在体液或中枢神经系统细胞的微量的发生时，可以通过两阶段分离过程包括去除在非还原末端具有唾液酸的糖蛋白选择性地富集 其从体液或中枢神经系统细胞，然后分离具有在其非还原末端的N-乙酰葡糖胺的糖蛋白。

公开(公告)号：EP3097402A1

公开(公告)日：2016-11-30

申请号：EP15708865.9

申请日：2015-01-13

申请人： Pulmonir Limited

发明人： LEWIS, Paul

IPC分类号： G01N21/35 ,  A61B5/00 ,  G01N33/50

CPC分类号： G01N21/3577 ,  G01N21/35 ,  G01N33/6893 ,  G01N2021/3595 ,  G01N2333/4725 ,  G01N2400/40 ,  G01N2800/122

摘要： A method and kit for diagnosing and monitoring the progress of COPD using FTIR spectral analysis of a sputum samples where spectral data is obtained and used to monitor the progression of the disease over time.