公开(公告)号：EP3224248A1

公开(公告)日：2017-10-04

申请号：EP15855878.3

申请日：2015-11-01

申请人： Shanghai Fochon Pharmaceutical Co. Ltd ,  Shanghai Institute Of Materia Medica Chinese Academy of Sciences ,  Chongqing Fochon Pharmaceutical Co., Ltd.

发明人： ZHAO, Xingdong ,  LI, Tongshuang ,  ZHOU, Zuwen ,  CHEN, Ling ,  LIU, Qihong ,  WANG, Xianlong ,  YANG, Lijun ,  RONG, Yue ,  TAN, Rui ,  YU, Chuiliang ,  JIANG, Lihua ,  LIU, Yanxin ,  LINGHU, Li ,  SUN, Jing ,  WANG, Weibo ,  DING, Jian ,  MENG, Linghua ,  GENG, Meiyu

IPC分类号： C07D221/04 ,  C07D221/00 ,  C07D513/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61P43/00 ,  A61P35/00

CPC分类号： A61K31/437 ,  A61K31/4375 ,  A61K31/505 ,  A61K31/52 ,  A61K45/06 ,  C07D519/00 ,  A61K2300/00

摘要： Provided are certain PI3K inhibitors, pharmaceutical compositions thereof, and methods of use therefor.

摘要翻译： 提供了某些PI3K抑制剂，其药物组合物及其使用方法。

公开(公告)号：EP2857403A1

公开(公告)日：2015-04-08

申请号：EP13798006.6

申请日：2013-04-23

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Shanghai Haihe Pharmaceutical Co., Ltd.

发明人： YANG, Chunhao ,  MENG, Linghua ,  CHEN, Yanhong ,  WANG, Xiang ,  TAN, Cun ,  LI, Jiapeng ,  DING, Jian ,  CHEN, Yi

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/5377 ,  A61K31/5386 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/5377 ,  A61K31/5386 ,  C07D498/08 ,  C07D519/00

摘要： The present invention relates to a pyrrolo[2,1- f ][1,2,4]triazine compound, an isomer thereof or a pharmaceutically acceptable salt, ester or hydrate thereof, and a preparation method and application thereof. The pyrrolo[2,1- f ][1,2,4]triazine compound has a structure expressed in general formula (I). The pyrrolo[2,1- f ][1,2,4]triazine compound expressed in general formula (I) can inhibit a phosphatidylinositol-3 kinase (PI3K) signal pathway, thereby being used to prepare medicine for treating phosphatidylinositol-3 kinase related diseases such as cancer.

摘要翻译： 本发明涉及吡咯并[2,1-f] [1,2,4]三嗪化合物，其异构体或其药学上可接受的盐，酯或水合物及其制备方法和应用。 吡咯并[2,1-f] [1,2,4]三嗪化合物具有通式（I）表示的结构。 通式（I）表示的吡咯并[2,1-f] [1,2,4]三嗪化合物可抑制磷脂酰肌醇-3激酶（PI3K）信号通路，从而用于制备治疗磷脂酰肌醇-3激酶 相关疾病如癌症。

公开(公告)号：EP2857403B1

公开(公告)日：2018-10-10

申请号：EP13798006.6

申请日：2013-04-23

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Shanghai Haihe Pharmaceutical Co., Ltd.

发明人： YANG, Chunhao ,  MENG, Linghua ,  CHEN, Yanhong ,  WANG, Xiang ,  TAN, Cun ,  LI, Jiapeng ,  DING, Jian ,  CHEN, Yi

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/5377 ,  A61K31/5386 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/5377 ,  A61K31/5386 ,  C07D498/08 ,  C07D519/00

摘要： The present invention relates to a pyrrolo[2,1- f ][1,2,4]triazine compound, an isomer thereof or a pharmaceutically acceptable salt, ester or hydrate thereof, and a preparation method and application thereof. The pyrrolo[2,1- f ][1,2,4]triazine compound has a structure expressed in general formula (I). The pyrrolo[2,1- f ][1,2,4]triazine compound expressed in general formula (I) can inhibit a phosphatidylinositol-3 kinase (PI3K) signal pathway, thereby being used to prepare medicine for treating phosphatidylinositol-3 kinase related diseases such as cancer.