公开(公告)号：EP3272755A1

公开(公告)日：2018-01-24

申请号：EP16764175.2

申请日：2016-03-03

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： NAN, Fajun ,  LI, Boliang ,  ZHAN, Yang ,  ZHANG, Xiaowei ,  XIONG, Ying ,  HU, Xichan ,  ZHANG, Yangming

IPC分类号： C07D493/04 ,  A61K31/4433 ,  A61P9/10

CPC分类号： A61K31/4433 ,  A61K31/352 ,  C07B37/04 ,  C07B49/00 ,  C07D493/04

摘要： The present invention relates to a series of analogues having a structure of a natural product Pyripyropene A as represented by formula I, and preparation method and use thereof, and particularly relates to analogues of the natural product Pyripyropene A, preparation method and application thereof in treating cardiovascular diseases such as atherosclerosis, etc. as an inhibitor of an acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).

摘要翻译： 本发明涉及一系列具有式I所示天然产物啶南平A结构的类似物及其制备方法和用途，特别涉及天然产物季戊萜烯A的类似物及其制备方法和应用， 心血管疾病如动脉粥样硬化等作为酰基辅酶A：胆固醇酰基转移酶2（ACAT2）的抑制剂。