公开(公告)号：EP3943496A1

公开(公告)日：2022-01-26

申请号：EP20779433.0

申请日：2020-03-20

申请人： Shouyao Holdings (Beijing) Co., Ltd.

发明人： ZHU, Yan ,  YAO, Jinsuo ,  WANG, Yeliu ,  YAN, Qin ,  HE, Weinan ,  CHEN, Changjun ,  SHANG, Xianxing ,  LI, Jijun ,  SUN, Yinghui ,  LI, Hongjuan ,  LU, Chang ,  ZHANG, Jiuqing ,  HOU, Deng ,  ZHANG, Xiaojun ,  LIU, Qichao

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61P35/00

摘要： The present invention relates to a WEE1 inhibitor, and the preparation and use thereof. The WEE1 inhibitor of the present invention is a compound of Formula I or a compound of Formula 11, or a pharmaceutically acceptable salt, solvate, polymorph or tautomer thereof. The present invention also provides use of the WEE1 inhibitor in the manufacture of a medicament for the treatment of a disease associated with WEE1 activity. The WEE1 inhibitor provided by the present invention can effectively treat the disease associated with WEE1 activity.