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公开(公告)号：EP3943496A1
公开(公告)日：2022-01-26
申请号：EP20779433.0
申请日：2020-03-20
发明人： ZHU, Yan , YAO, Jinsuo , WANG, Yeliu , YAN, Qin , HE, Weinan , CHEN, Changjun , SHANG, Xianxing , LI, Jijun , SUN, Yinghui , LI, Hongjuan , LU, Chang , ZHANG, Jiuqing , HOU, Deng , ZHANG, Xiaojun , LIU, Qichao
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61P35/00
摘要： The present invention relates to a WEE1 inhibitor, and the preparation and use thereof. The WEE1 inhibitor of the present invention is a compound of Formula I or a compound of Formula 11, or a pharmaceutically acceptable salt, solvate, polymorph or tautomer thereof. The present invention also provides use of the WEE1 inhibitor in the manufacture of a medicament for the treatment of a disease associated with WEE1 activity. The WEE1 inhibitor provided by the present invention can effectively treat the disease associated with WEE1 activity.
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公开(公告)号：EP3936509A1
公开(公告)日：2022-01-12
申请号：EP20771072.4
申请日：2020-03-06
发明人： WANG, Jinghan , YAO, Jinsuo , DUAN, Xiaowei , YUAN, Baokun , LIU, Xijie , JIAO, Nan , MIN, Wangyang , SUN, Ying , LU, Chang , SUN, Yinghui , ZHANG, Jiuqing , JI, Yeling , HOU, Deng
IPC分类号： C07D519/00 , C07D471/14 , A61K31/438 , A61K31/4995 , A61K31/4375 , A61K31/496 , A61K31/499 , A61K31/5386 , A61K31/5377 , A61K31/541 , A61P35/00
摘要： The invention relates to an FGFR4 kinase inhibitor, and the preparation method and use thereof. The invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, solvate, polymorph or tautomer thereof, and use thereof in the manufacture of a medicament for the treatment of an FGFR4 mediated disease.
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