-
1.发明公开Novel naphtyridine derivatives and pharmaceutical compositions containing them 失效Naphtyridinederivate und diese enthaltende pharmazeutischePräparate。
公开(公告)号：EP0009425A1
公开(公告)日：1980-04-02
申请号：EP79400587.6
申请日：1979-08-24
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D471/04 , Y10S514/96 , Y10S514/962
摘要： 1,8-naphthyridine compounds of the following formula
wherein X is a halogen atom especially fluorine or chlorine, R is an ethyl or vinyl group and R 2 is a hydrogen atom or a lower alkyl group containing 1 to 6 carbon atoms, as well as hydrates and nontoxic pharmaceutically acceptable salts thereof.
Said compounds have high antibacterial activities against gram-positive and gram-negative bacteria including Pseudomonas aeruginosa and low toxicity and can be used as antibacterial agents.摘要翻译： 其中X为卤素原子，特别是氟或氯，R1为乙基或乙烯基，R2为氢原子或含1至6个碳原子的低级烷基， 以及其水合物和无毒的药学上可接受的盐。 所述化合物对革兰氏阳性和革兰氏阴性细菌（包括铜绿假单胞菌）具有高抗菌活性，毒性低，可用作抗菌剂。
-
2.发明授权Novel naphtyridine derivatives and pharmaceutical compositions containing them 失效新型含氮吡啶衍生物和含有它们的药物组合物
公开(公告)号：EP0009425B1
公开(公告)日：1982-01-27
申请号：EP79400587.6
申请日：1979-08-24
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D471/04 , Y10S514/96 , Y10S514/962
-
3.发明授权
公开(公告)号：EP0027752B1
公开(公告)日：1983-12-21
申请号：EP80401369.6
申请日：1980-09-26
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04 , Y02P20/55
-
4.发明公开Naphthyridine derivatives, processes for their preparation and pharmaceutical compositions containing them 失效萘啶衍生物，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0027752A1
公开(公告)日：1981-04-29
申请号：EP80401369.6
申请日：1980-09-26
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04 , Y02P20/55
摘要： The present invention provides a 1,8-naphthyridine compound of the formula
wherein
R is hydrogen, methyl, ethyl or propyl, and a nontoxic pharmaceutically acceptable salt thereof,
-an antibacterial agent comprising said 1,8-naphtyridine compound
-and a process for prearing a 1,8-naphtyridine compound of the above formula which comprises
(A) reacting a compound oftheformula:
with a compound of the formula
or (B) decomposing a compound of the formula
or (C) treating a compound of the formula
with an acid or base, and/or reducrively cleaving it.-
5.发明授权Novel quinoline derivatives, processes for preparation thereof and antibacterial agent containing them 失效新型喹啉衍生物，其制备方法和含有它们的抗菌剂
公开(公告)号：EP0312085B1
公开(公告)日：1993-05-12
申请号：EP88117113.6
申请日：1988-10-14
发明人： Matsumoto, Jun-ichi , Minamida, Akira , Fujita, Masahiro 121, Fukusumi , Hirose, Tohru , Nakano, Junji , Nakamura, Shinichi
IPC分类号： C07D215/56 , C07D401/04 , A61K31/47 , A61K31/495
CPC分类号： C07D215/56
-
公开(公告)号：EP0221463B1
公开(公告)日：1991-08-14
申请号：EP86114748.6
申请日：1986-10-23
IPC分类号： C07D215/56 , C07D401/04 , A61K31/47 , A61K31/53 , A61K31/55
CPC分类号： C07D401/04 , C07D215/56
-
7.发明公开Novel quinoline derivatives, processes for preparation thereof and antibacterial agent containing them 失效Chinolinderivate，Verfahren zur Herstellung davon und diese enthaltendes antibakterielles Mittel。
公开(公告)号：EP0312085A2
公开(公告)日：1989-04-19
申请号：EP88117113.6
申请日：1988-10-14
发明人： Matsumoto, Jun-ichi , Minamida, Akira , Fujita, Masahiro 121, Fukusumi , Hirose, Tohru , Nakano, Junji , Nakamura, Shinichi
IPC分类号： C07D215/56 , C07D401/04 , A61K31/47 , A61K31/495
CPC分类号： C07D215/56
摘要： A quinoline derivative of the formula
wherein Z is an amino group or a halogen atom, and Ri, R 2 and R 3 are the same or different and each represents a hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms,
and an ester thereof and a salt of the derivative or the ester and processes for preparation thereof. These compounds show excellent antibacterial activity and are useful as antibacterial agents.摘要翻译： 式CHEM的喹啉衍生物，其中Z为氨基或卤原子，R1，R2和R3相同或不同，表示氢原子或碳原子数1〜5的低级烷基， 其酯和衍生物或酯的盐及其制备方法。 这些化合物显示出优异的抗菌活性，可用作抗菌剂。
-
公开(公告)号：EP0375658B1
公开(公告)日：1994-08-03
申请号：EP90101210.4
申请日：1986-10-23
IPC分类号： C07D215/56 , C07D401/04 , A61K31/47 , A61K31/495 , A61K31/55
CPC分类号： C07D401/04 , C07D215/56
-
9.发明公开Quinoline derivatives and processes for preparation thereof 失效Chinolin-Derivate und Verfahren zu deren Herstellung。
公开(公告)号：EP0375658A1
公开(公告)日：1990-06-27
申请号：EP90101210.4
申请日：1986-10-23
IPC分类号： C07D215/56 , C07D401/04 , A61K31/47 , A61K31/495 , A61K31/55
CPC分类号： C07D401/04 , C07D215/56
摘要： The present invention relates to a quinoline compound of the formula
wherein R₁, R₂ and R₃ are the same or different and each represents a hydrogen atom or a methyl group,
esters thereof and salts thereof, and processes for preparation thereof. These compounds show excellent antibacterial activity and are useful antibacterial agents. These compounds are also useful as intermediates for production of other antibacterial agents.摘要翻译： 本发明涉及式CHEM的喹啉化合物，其中R 1，R 2和R 3相同或不同，各自表示氢原子或甲基，其酯及其盐及其制备方法。 这些化合物显示出优异的抗菌活性，并且是有用的抗菌剂。 这些化合物也可用作生产其它抗菌剂的中间体。
-
10.发明公开Prevention or elimination of mycoplasma contamination of animal or plant cell culture 失效预防或消除动物或植物细胞培养的MYCOPLASMA污染
公开(公告)号：EP0348947A3
公开(公告)日：1990-03-28
申请号：EP89111783.0
申请日：1989-06-28
IPC分类号： C12N5/00
CPC分类号： C12N5/00
摘要： A method of preventing or eliminating mycoplasma contamination of animal or plant cell cultures, which comprises adding an anti-mycoplasmally effective amount of 5-amino-7-(2-aminomethylmorpholino)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid or its salt to a culture medium in which animal or plant cells are cultivated; and an agent or a preparation for preventing or eliminating mycoplasma contamination of animal or plant cell cultures, comprising 5-amino-7-(2-aminomethylmorpholino)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid or its salt.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.015 秒)
