-
1.发明授权Novel naphtyridine derivatives and pharmaceutical compositions containing them 失效新型含氮吡啶衍生物和含有它们的药物组合物
公开(公告)号：EP0009425B1
公开(公告)日：1982-01-27
申请号：EP79400587.6
申请日：1979-08-24
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D471/04 , Y10S514/96 , Y10S514/962
-
2.发明授权
公开(公告)号：EP0027752B1
公开(公告)日：1983-12-21
申请号：EP80401369.6
申请日：1980-09-26
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04 , Y02P20/55
-
3.发明公开Naphthyridine derivatives, processes for their preparation and pharmaceutical compositions containing them 失效萘啶衍生物，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0027752A1
公开(公告)日：1981-04-29
申请号：EP80401369.6
申请日：1980-09-26
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04 , Y02P20/55
摘要： The present invention provides a 1,8-naphthyridine compound of the formula
wherein
R is hydrogen, methyl, ethyl or propyl, and a nontoxic pharmaceutically acceptable salt thereof,
-an antibacterial agent comprising said 1,8-naphtyridine compound
-and a process for prearing a 1,8-naphtyridine compound of the above formula which comprises
(A) reacting a compound oftheformula:
with a compound of the formula
or (B) decomposing a compound of the formula
or (C) treating a compound of the formula
with an acid or base, and/or reducrively cleaving it.-
4.发明公开Novel naphtyridine derivatives and pharmaceutical compositions containing them 失效Naphtyridinederivate und diese enthaltende pharmazeutischePräparate。
公开(公告)号：EP0009425A1
公开(公告)日：1980-04-02
申请号：EP79400587.6
申请日：1979-08-24
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D471/04 , Y10S514/96 , Y10S514/962
摘要： 1,8-naphthyridine compounds of the following formula
wherein X is a halogen atom especially fluorine or chlorine, R is an ethyl or vinyl group and R 2 is a hydrogen atom or a lower alkyl group containing 1 to 6 carbon atoms, as well as hydrates and nontoxic pharmaceutically acceptable salts thereof.
Said compounds have high antibacterial activities against gram-positive and gram-negative bacteria including Pseudomonas aeruginosa and low toxicity and can be used as antibacterial agents.摘要翻译： 其中X为卤素原子，特别是氟或氯，R1为乙基或乙烯基，R2为氢原子或含1至6个碳原子的低级烷基， 以及其水合物和无毒的药学上可接受的盐。 所述化合物对革兰氏阳性和革兰氏阴性细菌（包括铜绿假单胞菌）具有高抗菌活性，毒性低，可用作抗菌剂。
-
公开(公告)号：EP0094804B1
公开(公告)日：1985-11-13
申请号：EP83302714.7
申请日：1983-05-13
发明人： Takase, Yoshiyuki , Furuta, Ryuji , Kawata, Shigeo , Naruto, Shunsuke , Nakamura, Shinichi , Minami, Akira
CPC分类号： C07K9/005
-
公开(公告)号：EP0094804A1
公开(公告)日：1983-11-23
申请号：EP83302714.7
申请日：1983-05-13
发明人： Takase, Yoshiyuki , Furuta, Ryuji , Kawata, Shigeo , Naruto, Shunsuke , Nakamura, Shinichi , Minami, Akira
CPC分类号： C07K9/005
摘要： Novel glucosaminyl muramyl peptide derivatives of the formula:
wherein X is hydrogen atom or a group of the formula: R 1 CO-, Y is hydroxy group or a group of the formula: -OR 2 ,
or
R, is an alkyl or alkenyl group, R 2 is a lower alkyl group or a phenylalkyl group, R 3 and r 4 are the same or different and are each hydrogen atom or an alkyl group, Y' is hydroxy group or a group of the formula: -OR 2 or
(D) and (L) mean the configuration, provided that when X is hydrogen atom, Y is a group of the formula:
or
and their pharmaceutically acceptable salts. They have excellent biological activities such as potentiating activity of nonspecific resistance to microbial infections and immunostimulant activity and hence are useful in the prophylaxis and treatment of various microbial infections and the treatment of cancer in mammals.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.013 秒)
