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公开(公告)号：EP2167497A2
公开(公告)日：2010-03-31
申请号：EP08781174.1
申请日：2008-06-30
发明人： COSSROW, Jennifer , GUAN, Bing , ISHCHENKO, Alexey , JONES, John, Howard , KUMARAVEL, Gnanasambandam , LUGOVSKOY, Alexey , PENG, Hairuo , POWELL, Noel , RAIMUNDO, Brian , TANAKA, Hiroko , VESSELS, Jeffrey , WYNN, Thomas , XIN, Zhili
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61P35/00 , A61K31/505
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently selected from nitrogen, oxygen, or sulfur; L1 is a direct bond of an optionally substituted, straight or branched C1-6 alkylene chain; L2 is a direct bond, or is an optionally substituted, straight or branched C1-6 alkylene chain wherein 1 or 2 methylene units of L2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydrogen or an optionally substituted C1-6 aliphatic group;
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公开(公告)号：EP2167489A2
公开(公告)日：2010-03-31
申请号：EP08772238.5
申请日：2008-06-30
发明人： CHEN, Weirong , COSSROW, Jennifer , FRANKLIN, Lioyd , GUAN, Bing , JONES, John, Howard , KUMARAVEL, Gnanasambandam , LANE, Benjamin , LITTKE, Adam , LUGOVSKOY, Alexey , PENG, Hairuo , POWELL, Noel , RAIMUNDO, Brian , TANAKA, Hiroko , VESSELS, Jeffrey , WYNN, Thomas , XIN, Zhili
IPC分类号： C07D401/12
CPC分类号： C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物和治疗Raf介导的疾病的方法。
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3.发明公开
公开(公告)号：EP3231798A1
公开(公告)日：2017-10-18
申请号：EP17168722.1
申请日：2008-06-30
发明人： CHEN, Weirong , COSSROW, Jennifer , FRANKLIN, Lioyd , GUAN, Bing , JONES, John, Howard , KUMARAVEL, Gnanasambandam , LANE, Benjamin , LITTKE, Adam , LUGOVSKOY, Alexey , PENG, Hairuo , POWELL, Noel , RAIMUNDO, Brian , TANAKA, Hiroko , VESSELS, Jeffrey , WYNN, Thomas , XIN, Zhili
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04 , A61K31/506 , A61P29/00 , A61P35/00
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
摘要翻译： 本发明提供可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物和治疗Raf介导的疾病的方法。
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公开(公告)号：EP3231798B1
公开(公告)日：2019-10-09
申请号：EP17168722.1
申请日：2008-06-30
发明人： CHEN, Weirong , COSSROW, Jennifer , FRANKLIN, Lioyd , GUAN, Bing , JONES, John, Howard , KUMARAVEL, Gnanasambandam , LANE, Benjamin , LITTKE, Adam , LUGOVSKOY, Alexey , PENG, Hairuo , POWELL, Noel , RAIMUNDO, Brian , TANAKA, Hiroko , VESSELS, Jeffrey , WYNN, Thomas , XIN, Zhili
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04 , A61K31/506 , A61P29/00 , A61P35/00
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