公开(公告)号：EP3231798B1

公开(公告)日：2019-10-09

申请号：EP17168722.1

申请日：2008-06-30

申请人： Sunesis Pharmaceuticals, Inc. ,  Millennium Pharmaceuticals, Inc.

发明人： CHEN, Weirong ,  COSSROW, Jennifer ,  FRANKLIN, Lioyd ,  GUAN, Bing ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LANE, Benjamin ,  LITTKE, Adam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00

公开(公告)号：EP3231798A1

公开(公告)日：2017-10-18

申请号：EP17168722.1

申请日：2008-06-30

申请人： Sunesis Pharmaceuticals, Inc. ,  Millennium Pharmaceuticals, Inc.

发明人： CHEN, Weirong ,  COSSROW, Jennifer ,  FRANKLIN, Lioyd ,  GUAN, Bing ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LANE, Benjamin ,  LITTKE, Adam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00

摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

摘要翻译： 本发明提供可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物和治疗Raf介导的疾病的方法。

公开(公告)号：EP2167497A2

公开(公告)日：2010-03-31

申请号：EP08781174.1

申请日：2008-06-30

申请人： Sunesis Pharmaceuticals, Inc. ,  Biogen Idec MA Inc.

发明人： COSSROW, Jennifer ,  GUAN, Bing ,  ISHCHENKO, Alexey ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

IPC分类号： C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61P35/00 ,  A61K31/505

CPC分类号： C07D417/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently selected from nitrogen, oxygen, or sulfur; L1 is a direct bond of an optionally substituted, straight or branched C1-6 alkylene chain; L2 is a direct bond, or is an optionally substituted, straight or branched C1-6 alkylene chain wherein 1 or 2 methylene units of L2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydrogen or an optionally substituted C1-6 aliphatic group;

公开(公告)号：EP2167489A2

公开(公告)日：2010-03-31

申请号：EP08772238.5

申请日：2008-06-30

申请人： Sunesis Pharmaceuticals, Inc. ,  Biogen Idec MA Inc.

发明人： CHEN, Weirong ,  COSSROW, Jennifer ,  FRANKLIN, Lioyd ,  GUAN, Bing ,  JONES, John, Howard ,  KUMARAVEL, Gnanasambandam ,  LANE, Benjamin ,  LITTKE, Adam ,  LUGOVSKOY, Alexey ,  PENG, Hairuo ,  POWELL, Noel ,  RAIMUNDO, Brian ,  TANAKA, Hiroko ,  VESSELS, Jeffrey ,  WYNN, Thomas ,  XIN, Zhili

IPC分类号： C07D401/12

CPC分类号： C07D417/14 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07F9/65583

摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

摘要翻译： 本发明提供可用作Raf蛋白激酶抑制剂的化合物。 本发明还提供了其组合物和治疗Raf介导的疾病的方法。