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22 条记录 (耗时 0.013 秒)

    4-PHENYLPIPERIDINE COMPOUNDS
    2.
    发明授权
    4-PHENYLPIPERIDINE COMPOUNDS 失效
    4-苯基哌啶类化合物

    公开(公告)号：EP0994872B1

    公开(公告)日：2001-04-25

    申请号：EP97926276.3

    申请日：1997-06-10

    申请人： Synthon B.V.

    发明人： BENNEKER, Franciscus, Bernardus, Gemma ,  VAN DALEN, Frans ,  LEMMENS, Jacobus, Maria ,  PETERS, Theodorus, Hendricus, Antonium ,  PICHA, Frantisek

    IPC分类号： C07D405/12 ,  A61K31/445

    CPC分类号： C07D405/12 ,  C07D211/20

    摘要： The invention relates to a compound, and pharmaceutically acceptable salts, having formula (I), wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C1-4 alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl; R1 represents hydrogen, trifluoro (C¿1-4?) alkyl, alkyl or alkynyl; X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy; R?2¿ represents: a C¿1?-C10 alkyl group; a phenyl group optionally substituted by one or more of the following groups: a C1-C10 alkyl group, a halogen group, a nitro group, hydroxy group, and/or an alkoxy group.

    摘要翻译： 本发明涉及具有式（I）的化合物及其药学上可接受的盐，其中：R表示具有1-4个碳原子的烷基或炔基或任选被C 1-4烷基，烷硫基，烷氧基， 卤素，硝基，酰基氨基，甲基磺酰基或亚甲基二氧基，或代表四氢萘基; R1代表氢，三氟（C1-4）烷基，烷基或炔基; X代表氢，具有1-4个碳原子的烷基，烷氧基，三氟烷基，羟基，卤素，甲硫基或芳烷氧基; R 2'代表：C 1 -C 10烷基; 任选被一个或多个以下基团取代的苯基：C1-C10烷基，卤素基团，硝基，羟基和/或烷氧基。

    4-PHENYLPIPERIDINE COMPOUNDS
    7.
    发明授权
    4-PHENYLPIPERIDINE COMPOUNDS 失效
    4-苯基哌啶化合物

    公开(公告)号：EP0994872B9

    公开(公告)日：2001-12-05

    申请号：EP97926276.3

    申请日：1997-06-10

    申请人： Synthon B.V.

    发明人： BENNEKER, Franciscus, Bernardus, Gemma ,  VAN DALEN, Frans ,  LEMMENS, Jacobus, Maria ,  PETERS, Theodorus, Hendricus, Antonium ,  PICHA, Frantisek

    IPC分类号： C07D405/12 ,  A61K31/445

    CPC分类号： C07D405/12 ,  C07D211/20

    摘要： The invention relates to a compound, and pharmaceutically acceptable salts, having formula (I), wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C1-4 alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl; R1 represents hydrogen, trifluoro (C¿1-4?) alkyl, alkyl or alkynyl; X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy; R?2¿ represents: a C¿1?-C10 alkyl group; a phenyl group optionally substituted by one or more of the following groups: a C1-C10 alkyl group, a halogen group, a nitro group, hydroxy group, and/or an alkoxy group.

    4-PHENYLPIPERIDINE COMPOUNDS
    8.
    发明公开
    4-PHENYLPIPERIDINE COMPOUNDS 失效
    4-苯基衍生物

    公开(公告)号：EP0994872A1

    公开(公告)日：2000-04-26

    申请号：EP97926276.3

    申请日：1997-06-10

    申请人： Synthon B.V.

    发明人： BENNEKER, Franciscus, Bernardus, Gemma ,  VAN DALEN, Frans ,  LEMMENS, Jacobus, Maria ,  PETERS, Theodorus, Hendricus, Antonium ,  PICHA, Frantisek

    IPC分类号： C07D405/12 ,  A61K31/445

    CPC分类号： C07D405/12 ,  C07D211/20

    摘要： The invention relates to a compound, and pharmaceutically acceptable salts, having formula (I), wherein: R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl group optionally substituted by C1-4 alkyl, alkylthio, alkoxy, halogen, nitro, acylamino, methylsulfonyl or methylenedioxy, or represents tetrahydronaphthyl; R1 represents hydrogen, trifluoro (C¿1-4?) alkyl, alkyl or alkynyl; X represents hydrogen, alkyl having 1-4 carbon atoms, alkoxy, trifluoroalkyl, hydroxy, halogen, methylthio or aralkoxy; R?2¿ represents: a C¿1?-C10 alkyl group; a phenyl group optionally substituted by one or more of the following groups: a C1-C10 alkyl group, a halogen group, a nitro group, hydroxy group, and/or an alkoxy group.

    MODIFIED RELEASE TAMSULOSIN TABLETS
    9.
    发明授权
    MODIFIED RELEASE TAMSULOSIN TABLETS 有权

    公开(公告)号：EP1441713B2

    公开(公告)日：2018-11-14

    申请号：EP02780143.0

    申请日：2002-11-06

    申请人： Synthon B.V.

    发明人： LEMMENS, Jacobus, Maria ,  PLATTEEUW, Johannes, Jan ,  VAN DALEN, Frans ,  ORTEGA, Arturo, Siles ,  ESCOI, Juan, Cucala

    IPC分类号： A61K31/18 ,  A61K9/20 ,  A61K9/28 ,  A61K9/48 ,  A61P13/08

    CPC分类号： A61K9/2009 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/2846 ,  A61K9/4808 ,  A61K31/18

    摘要： The invention relates to a pharmaceutical tablet comprising a tablet matrix having dispersed therein 0.1 to 10 mg of tamsulosin or a pharmaceutically acceptable salt thereof, and optionally having an enteric coating over said matrix, wherein said tablet is a modified release tablet and has a dissolution profile such that in each of the media SIF, FaSSIF, and FeSSIF, said tablet releases not more than 60% of said tamsulosin at 2 hours elapsed time in USP 2 apparatus using 500 ml of said media at 50-100 rpm paddle speed, to a monolithic pharmaceutical tablet, comprising 0.1 to 10 mg of tamsulosin or a pharmaceutically acceptable salt thereof, 10 wt% - 90 wt% hydroxypropyl methylcellulose, and a total tablet weight of 10 to 300 mg, to a unit dosage form for treating or ameliorating the conditions of benign prostatic hyperplasia comprising an effective amount of one or more tablets as mentioned above, and to a method for treating the symptoms of benign prostatic hyperplasia, which comprises administering to a patient in need thereof one or more tablets as mentioned above.