公开(公告)号：EP0767170B1

公开(公告)日：2002-10-23

申请号：EP96909366.5

申请日：1996-04-12

申请人： TAIHO PHARMACEUTICAL CO., LTD.

发明人： KONNO, Yasuo ,  NOZAKI, Kenji ,  YAMADA, Shozo ,  ASAO, Tetsuji ,  SUZUKI, Takashi ,  KIMURA, Masayasu

IPC分类号： C07D239/42 ,  C07D401/04 ,  C07D403/12 ,  C07D417/04 ,  C07F9/12 ,  A61K31/505 ,  A61K31/66

CPC分类号： C07D239/42 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D403/12 ,  C07D417/04 ,  C07F9/65122

摘要： Novel 4,6-diarylpyrimidine derivatives represented by general formula (1), salts thereof, a process for producing the same, and a drug comprising the same as the active ingredient, wherein R represents a heterocycle or amino optionally substituted by one to four lower alkyl groups; and Ar represents phenyl, naphthyl or an aromatic heterocycle optionally having one to four substituents. The compounds have an excellent effect of inhibiting neovascularization and are useful as a remedy for solid tumor, rheumatism, diabetic retinopathy and psoriasis.

公开(公告)号：EP0767170A1

公开(公告)日：1997-04-09

申请号：EP96909366.5

申请日：1996-04-12

申请人： TAIHO PHARMACEUTICAL CO., LTD.

发明人： KONNO, Yasuo ,  NOZAKI, Kenji ,  YAMADA, Shozo ,  ASAO, Tetsuji ,  SUZUKI, Takashi ,  KIMURA, Masayasu

IPC分类号： C07D239/42 ,  C07D401/12 ,  A61K31/505

CPC分类号： C07D239/42 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D403/12 ,  C07D417/04 ,  C07F9/65122

摘要： Described are a 4,6-diarylpyrimidine derivative represented by the following formula (1):
wherein R represents a heterocyclic ring which may be substituted by one to four lower alkyl groups or an amino group and Ar represents a phenyl, naphthyl or aromatic heterocyclic group which may have one to four substituents, and a salt thereof; a preparation process therefor; and a pharmaceutical containing it as an effective ingredient. It has excellent neovascular inhibitory action and is useful as a therapeutic agent for solid cancer, rheumatism, diabetic retinopathy or psoriasis.