公开(公告)号：EP1304377B1

公开(公告)日：2008-10-22

申请号：EP01984244.2

申请日：2001-07-18

申请人： TAKARA BIO INC.

发明人： TSUBOSA, Yasuhiro ,  AOYAGI, Kazuhiko ,  SASAKI, Hiroki ,  TERADA, Masaaki ,  MINENO, Junichi ,  ASADA, Kiyozo ,  KATO, Ikunoshin

IPC分类号： C12N15/12 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/158

摘要： A method of selecting a marker gene which is useful in identifying cancer; a method of identifying cancer by using this gene; a method of detecting cancer, a kit to be used in the identification or detection method; and a DNA array holding the above gene. Thus, it is possible to obtain a gene which shows a change in the expression dose independently from a gene showing a change in the expression specifically at the proliferation of cells and specifically to each cancer sample. Use of this gene makes it possible to conveniently and quickly identify or detect cancer withou resort to any surgical operations, thereby contributing to the diagnonis and treatment of cancer, etc.

公开(公告)号：EP1304377A1

公开(公告)日：2003-04-23

申请号：EP01984244.2

申请日：2001-07-18

申请人： TAKARA BIO INC.

发明人： TSUBOSA, Yasuhiro ,  AOYAGI, Kazuhiko ,  SASAKI, Hiroki ,  TERADA, Masaaki ,  MINENO, Junichi ,  ASADA, Kiyozo ,  KATO, Ikunoshin

IPC分类号： C12N15/12 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/158

摘要： To provide a method for selecting a marker gene useful for cancer classification; a method for classifying cancer using the gene; a method for detecting cancer; a kit usable for the classification method or detection method; and a DNA array carrying the gene. According to the present invention, there can be obtained a gene, wherein expression of the above gene is altered independently from genes each of which expression is altered specifically during cell proliferation and expression level of the above gene is specifically altered depending on every type of cancer samples to be tested, whereby the classification or detection of cancer can be carried out conveniently and quickly without giving surgical treatment. Therefore, the present invention is useful for the diagnosis, the treatment, and the like of cancer.

摘要翻译： 提供选择用于癌症分类的标记基因的方法; 使用该基因分类癌症的方法; 检测癌症的方法; 可用于分类方法或检测方法的试剂盒; 和携带该基因的DNA阵列。 根据本发明，可以获得上述基因的表达独立于在细胞增殖期间特异性改变的基因的各个基因的变化，并且根据每种类型的癌症特异性地改变上述基因的表达水平 待测试的样品，从而可以方便快捷地进行癌症的分类或检测，而无需外科治疗。 因此，本发明对癌症的诊断，治疗等有用。