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公开(公告)号：EP0826686A2
公开(公告)日：1998-03-04
申请号：EP97115200.4
申请日：1997-09-02
IPC分类号： C07D471/16 , A61K31/415 , A61K31/495
CPC分类号： C07D471/16
摘要： A pharmaceutical composition for treating or preventing proliferative glomerulonephritis, which comprises a compound of the formula:
wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which may be substituted with oxo or thioxo; ring Q may be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted mercapto group; and
R 1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, and a novel compound of the formula:
wherein ring A a may have one oxo group; D is a bond or an optionally substituted divalent hydrocarbon group;
ring W is an optionally substituted nitrogen-containing heterocyclic ring; ring Q may be substituted; and R 3 is an electron-withdrawing group, or a salt thereof, which have excellent PDGF-inhibiting activities, activities of ameliorating renal diseases and activities of lowering lipid level and are less toxic and are useful as a preventive and treating agent for cardisvascular diseases.摘要翻译： 一种用于治疗或预防增生性肾小球肾炎的药物组合物，其包含下式的化合物：其中环A为含氮杂环，具有两个氮原子作为杂原子，其可以被氧代或硫代取代; 环Q可以被取代; Y是任选取代的烃基，任选取代的羟基或任选取代的巯基; R1为氢原子，卤素原子，任选取代的烃基或酰基，或其盐，以及下式的新化合物：其中环Aa可以具有一个氧代基团; D是键或任选取代的二价烃基; 环W是任选取代的含氮杂环; 环Q可以被取代; R3是具有优异的PDGF抑制活性的吸电子基团或其盐，改善肾脏疾病的活性和降低血脂水平的活性，毒性较小，可用作心血管疾病的预防和治疗剂。
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公开(公告)号：EP0826686A3
公开(公告)日：1998-05-06
申请号：EP97115200.4
申请日：1997-09-02
IPC分类号： C07D471/16 , A61K31/415 , A61K31/495
CPC分类号： C07D471/16
摘要： A pharmaceutical composition for treating or preventing proliferative glomerulonephritis, which comprises a compound of the formula:
wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which may be substituted with oxo or thioxo; ring Q may be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted mercapto group; and R 1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, and a novel compound of the formula:
wherein ring A a may have one oxo group; D is a bond or an optionally substituted divalent hydrocarbon group; ring W is an optionally substituted nitrogen-containing heterocyclic ring; ring Q may be substituted; and R 3 is an electron-withdrawing group, or a salt thereof, which have excellent PDGF-inhibiting activities, activities of ameliorating renal diseases and activities of lowering lipid level and are less toxic and are useful as a preventive and treating agent for cardisvascular diseases.
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