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公开(公告)号：EP0826686A2
公开(公告)日：1998-03-04
申请号：EP97115200.4
申请日：1997-09-02
IPC分类号： C07D471/16 , A61K31/415 , A61K31/495
CPC分类号： C07D471/16
摘要： A pharmaceutical composition for treating or preventing proliferative glomerulonephritis, which comprises a compound of the formula:
wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which may be substituted with oxo or thioxo; ring Q may be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted mercapto group; and
R 1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, and a novel compound of the formula:
wherein ring A a may have one oxo group; D is a bond or an optionally substituted divalent hydrocarbon group;
ring W is an optionally substituted nitrogen-containing heterocyclic ring; ring Q may be substituted; and R 3 is an electron-withdrawing group, or a salt thereof, which have excellent PDGF-inhibiting activities, activities of ameliorating renal diseases and activities of lowering lipid level and are less toxic and are useful as a preventive and treating agent for cardisvascular diseases.摘要翻译： 一种用于治疗或预防增生性肾小球肾炎的药物组合物，其包含下式的化合物：其中环A为含氮杂环，具有两个氮原子作为杂原子，其可以被氧代或硫代取代; 环Q可以被取代; Y是任选取代的烃基，任选取代的羟基或任选取代的巯基; R1为氢原子，卤素原子，任选取代的烃基或酰基，或其盐，以及下式的新化合物：其中环Aa可以具有一个氧代基团; D是键或任选取代的二价烃基; 环W是任选取代的含氮杂环; 环Q可以被取代; R3是具有优异的PDGF抑制活性的吸电子基团或其盐，改善肾脏疾病的活性和降低血脂水平的活性，毒性较小，可用作心血管疾病的预防和治疗剂。
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2.发明公开Angiotensin II antagonists as a prophylactic or therapeutic drug for renal diseases 失效血管紧张素II拮抗剂预防和治疗MittelfürNierenkrankheiten。
公开(公告)号：EP0622077A1
公开(公告)日：1994-11-02
申请号：EP94106203.6
申请日：1994-04-21
发明人： Nishikawa, Kohei , Shibouta, Yumiko , Kubo, Keiji
IPC分类号： A61K31/415
CPC分类号： A61K31/4184 , A61K31/415 , A61K31/4245 , Y02A50/395
摘要： This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I)
wherein R¹ stands for H or an optionally substituted hydrocarbon residue; R² stands for an optionally esterified carboxyl group; R³ stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R²; Y stands for a bond, -O-, -S(O) m - (wherein m stands for 0, 1 or 2), or -N(R⁴)- (wherein R⁴ stands for H or an optionally substituted alkyl group).摘要翻译： 本发明涉及用于糖尿病性肾病或肾小球肾炎的预防或治疗药物，其包含作为活性成分的由通式（I）表示的化合物或其盐
，其中R 1表示H或任选取代的烃残基 ; R 2代表任意酯化的羧基; R 3代表实际上或潜在地能够形成阴离子的基团; X表示亚苯基和苯基直接或通过原子链长度为2或更小的间隔物彼此结合; n代表1或2; 除了R 2外，环A代表具有任选取代基的苯环; Y代表键，-O-，-S（O）m - （其中m代表0,1或2）或-N（R 4） - （其中R 4代表H或 任选取代的烷基）。 -
公开(公告)号：EP0471236B1
公开(公告)日：1995-03-15
申请号：EP91112798.3
申请日：1991-07-30
IPC分类号： A61K31/435 , A61K31/44 , C07D471/04
CPC分类号： C07D471/04
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4.发明授权Angiotensin II antagonists as a prophylactic or therapeutic drug for renal diseases 失效血管紧张素Ⅱ拮抗剂作为肾脏疾病的预防和治疗剂
公开(公告)号：EP0622077B1
公开(公告)日：2000-07-05
申请号：EP94106203.6
申请日：1994-04-21
发明人： Nishikawa, Kohei , Shibouta, Yumiko , Kubo, Keiji
IPC分类号： A61K31/415
CPC分类号： A61K31/4184 , A61K31/415 , A61K31/4245 , Y02A50/395
摘要： This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) wherein R stands for H or an optionally substituted hydrocarbon residue; R stands for an optionally esterified carboxyl group; R stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R ; Y stands for a bond, -O-, -S(O)m- (wherein m stands for 0, 1 or 2), or -N(R )- (wherein R stands for H or an optionally substituted alkyl group).
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公开(公告)号：EP0826686A3
公开(公告)日：1998-05-06
申请号：EP97115200.4
申请日：1997-09-02
IPC分类号： C07D471/16 , A61K31/415 , A61K31/495
CPC分类号： C07D471/16
摘要： A pharmaceutical composition for treating or preventing proliferative glomerulonephritis, which comprises a compound of the formula:
wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which may be substituted with oxo or thioxo; ring Q may be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted mercapto group; and R 1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, and a novel compound of the formula:
wherein ring A a may have one oxo group; D is a bond or an optionally substituted divalent hydrocarbon group; ring W is an optionally substituted nitrogen-containing heterocyclic ring; ring Q may be substituted; and R 3 is an electron-withdrawing group, or a salt thereof, which have excellent PDGF-inhibiting activities, activities of ameliorating renal diseases and activities of lowering lipid level and are less toxic and are useful as a preventive and treating agent for cardisvascular diseases.-
公开(公告)号：EP0471236A1
公开(公告)日：1992-02-19
申请号：EP91112798.3
申请日：1991-07-30
IPC分类号： A61K31/435 , A61K31/44 , C07D471/04
CPC分类号： C07D471/04
摘要： A calmodulin inhibitory composition containing a compound of the formula (I):
as well as an angiogenesis inhibitory composition containing a compound of the formula (1):
are disclosed.摘要翻译： 公开了含有式（I）化合物：
的钙调蛋白抑制组合物以及含有式（1）化合物： 的血管发生抑制组合物。 C
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