公开(公告)号：EP1357115A4

公开(公告)日：2004-04-07

申请号：EP01272544

申请日：2001-12-28

申请人： TAKEDA CHEMICAL INDUSTRIES LTD

发明人： MOMOSE YU ,  MAEKAWA TSUYOSHI ,  TAKAKURA NOBUYUKI ,  ODAKA HIROYUKI ,  KIMURA HIROYUKI ,  ITO TATSUYA

IPC分类号： A61P3/06 ,  A61P3/10 ,  A61P9/12 ,  A61P13/12 ,  A61P19/10 ,  A61P27/02 ,  A61P31/04 ,  A61P43/00 ,  C07D263/32 ,  C07D277/24 ,  C07D277/32 ,  C07D277/34 ,  C07D277/42 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D403/04 ,  C07D263/32 ,  C07D277/24 ,  C07D277/42 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

摘要： Alkanoic acid derivatives represented by the general formula (I) or salts thereof, useful as preventive and/or therapeutic agents for diabetes, hyperlipidemia, impaired glucose tolerance, and so on: (I) wherein R1 is an optionally substituted five-membered aromatic heterocyclic group; X is a free valency or the like; Q is a divalent hydrocarbon group containing 1 to 20 carbon atoms; Y is a free valency or the like; A is an aromatic ring which may have one to three substituents; Z is -(CH¿2)n-Z?1- (wherein n is an integer of 1 to 8; and Z1 is oxygen or the like) or the like; B is an optionally mono- to tri-substituted pyridine ring or the like; U is a free valency or the like; W is a divalent hydrocarbon group containing 1 to 20 carbon atoms; and R3 is -OH or the like, with the proviso that when B is an optionally mono- to tri-substituted benzene ring, U is a free valency.