公开(公告)号：EP1789389A1

公开(公告)日：2007-05-30

申请号：EP05785646.0

申请日：2005-09-16

申请人： TANABE SEIYAKU CO., LTD.

发明人： MIYAKE, Tsutomu, c/o TANABE SEIYAKU Co, Ltd, ,  YAMANAKA, Takeshi c/o TANABE SEIYAKU Co, Ltd, ,  KINO, Rie c/o TANABE SEIYAKU Co, Ltd, ,  ASAI, Hidetoshi c/o TANABE SEIYAKU Co, Ltd,

IPC分类号： C07D211/58 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  A61P43/00 ,  C07D401/04 ,  C07D401/06 ,  A61K31/4468 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06

CPC分类号： C07D211/58 ,  C07D211/62 ,  C07D211/78 ,  C07D211/96 ,  C07D257/04 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06

摘要： The present invention is to provide a piperidine compound represented by the formula [I]: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted benzene ring, R1 is hydrogen atom or a substituent for amino group, R2 is hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, Z is oxygen atom or -N(R3)-, R3 is hydrogen atom or an optionally substituted alkyl group, R4a and R4b may be the same or different, and each is hydrogen atom or an optionally substituted alkyl group, or a pharmaceutically acceptable salt thereof, which has an excellent tachykinin receptor antagonistic action.