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公开(公告)号：EP1833978A1
公开(公告)日：2007-09-19
申请号：EP06717426.8
申请日：2006-01-04
申请人： TELIK, INC.
发明人： AURRECOECHEA, Natalia , KELSON, Andrew, B. , MACSATA, Robert, W. , ROBINSON, Louise , SANCHEZ, Anthony, J. , SANTIAGO, Nicholas, M. , SCHOW, Steven, R. , SIMON, Reyna, J.
CPC分类号： C07K5/0215 , A61K38/00
摘要： Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.
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2.发明公开2-[1H-BENZIMIDAZOL-2(3H)-YLIDENE]-2-(PYRIMIDIN-2-YL)ACETAMIDES AND 2-[BENZOTHIAZOL-2(3H)-YLIDENE]-2-(PYRIMIDIN-2-YL)ACETAMIDES AS KINASE INHIBITORS 审中-公开2- [苯并咪唑-2（3H） - 基] -2-（吡咯烷-2-基）乙酰胺ALA的2- [1H-苯并咪唑-2（3H） - 基] -2-（吡咯烷-2-基）乙酰胺 KINASEINHIBITOREN
公开(公告)号：EP2346856A1
公开(公告)日：2011-07-27
申请号：EP09792996.2
申请日：2009-09-25
申请人： Telik, Inc.
发明人： AURRECOECHEA, Natalia , BEROZA, Paul P. , DAMODARAN, Komath V. , PONTIUS, Karen Y. , ROBINSON, Louise , SIMON, Reyna J. , VU, Truong , WEBER, Kevin T.
IPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D417/06 , C07D417/14 , A61K31/506 , A61P35/00
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D417/06 , C07D417/14
摘要： 2-[1
H -benzimidazol-2(3
H )-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3
H )-ylidene]-2-(pyrimidin-2-yl)acetamides and their salts are kinase inhibitors, useful in the treatment of cancer. Formula I-
公开(公告)号：EP1833978B1
公开(公告)日：2008-10-08
申请号：EP06717426.8
申请日：2006-01-04
申请人： TELIK, INC.
发明人： AURRECOECHEA, Natalia , KELSON, Andrew, B. , MACSATA, Robert, W. , ROBINSON, Louise , SANCHEZ, Anthony, J. , SANTIAGO, Nicholas, M. , SCHOW, Steven, R. , SIMON, Reyna, J.
CPC分类号： C07K5/0215 , A61K38/00
摘要： Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.
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公开(公告)号：EP1833842B1
公开(公告)日：2008-10-08
申请号：EP06717699.0
申请日：2006-01-05
申请人： TELIK, INC.
CPC分类号： C07K5/0215 , A61K38/00
摘要： Tripeptide and tetrapeptide sulfones, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow cells, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.
摘要翻译： 三肽和四肽砜，含有它们的药物组合物，它们的药物用途及其制备。 该化合物可用于增强化学治疗剂在肿瘤细胞中的细胞毒性作用，选择性地在肿瘤细胞中发挥毒性，提高骨髓细胞中GM祖细胞的产量，刺激骨髓分化，减轻化疗剂的骨髓抑制作用，以及 调节骨髓造血功能。
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公开(公告)号：EP1833842A1
公开(公告)日：2007-09-19
申请号：EP06717699.0
申请日：2006-01-05
申请人： TELIK, INC.
CPC分类号： C07K5/0215 , A61K38/00
摘要： Tripeptide and tetrapeptide sulfones, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow cells, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.
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