公开(公告)号：EP1833978B1

公开(公告)日：2008-10-08

申请号：EP06717426.8

申请日：2006-01-04

申请人： TELIK, INC.

发明人： AURRECOECHEA, Natalia ,  KELSON, Andrew, B. ,  MACSATA, Robert, W. ,  ROBINSON, Louise ,  SANCHEZ, Anthony, J. ,  SANTIAGO, Nicholas, M. ,  SCHOW, Steven, R. ,  SIMON, Reyna, J.

IPC分类号： C12P21/02 ,  C07K5/08 ,  A61K38/06 ,  A61P31/00

CPC分类号： C07K5/0215 ,  A61K38/00

摘要： Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.

公开(公告)号：EP1791549A2

公开(公告)日：2007-06-06

申请号：EP05804834.9

申请日：2005-05-20

申请人： TELIK, INC.

发明人： ALLEN, David, R. ,  MA, Wenli ,  PETERSON, Brian, T. ,  ROBINSON, Louise ,  SCHOW, Steven, R. ,  SHI, Songyuan ,  SIMON, Reyna, J. ,  WEBER, Kevin, T. ,  WICK, Michael, M.

IPC分类号： A61K31/664

CPC分类号： C07F9/2458 ,  C07F9/2408 ,  C07F9/5721 ,  C07F9/581 ,  C07F9/582 ,  C07F9/591 ,  C07F9/598 ,  C07F9/650958 ,  C07F9/6533 ,  C07F9/65515 ,  C07F9/655345 ,  C07F9/65616

摘要： Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.

公开(公告)号：EP1833978A1

公开(公告)日：2007-09-19

申请号：EP06717426.8

申请日：2006-01-04

申请人： TELIK, INC.

发明人： AURRECOECHEA, Natalia ,  KELSON, Andrew, B. ,  MACSATA, Robert, W. ,  ROBINSON, Louise ,  SANCHEZ, Anthony, J. ,  SANTIAGO, Nicholas, M. ,  SCHOW, Steven, R. ,  SIMON, Reyna, J.

IPC分类号： C12P21/02 ,  C07K5/08 ,  A61K38/06 ,  A61P31/00

CPC分类号： C07K5/0215 ,  A61K38/00

摘要： Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.