专利检索 ap:("THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES") AND inv:"GREIG, Nigel" 第 1 页

1.

发明授权
DIFFERENTIATION OF NON-INSULIN PRODUCING CELLS INTO INSULIN PRODUCING CELLS BY GLP-1 OR EXENDIN-4 AND USES THEREOF 有权
标题翻译：非胰岛素生产细胞分化为胰岛素GLP-1和艾塞那肽-4及其用途

公开(公告)号：EP1105460B1

公开(公告)日：2009-10-07

申请号：EP99942066.4

申请日：1999-08-10

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： EGAN, Josephine , PERFETTI, Riccardo , PASSANITI, Antonino , GREIG, Nigel , HOLLOWAY, Harold

IPC分类号： C12N5/06 , A61K38/22 , A61K38/26 , C07K14/605 , C07K14/575

CPC分类号： C12N5/0676 , A61K35/39 , A61K38/00 , A61K38/26 , C07K14/57563 , C12N2501/335

摘要： The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragments thereof. The present invention also relates to methods of differentiating non-insulin producing cells into insulin producing cells and of enriching a population of cells for insulin-producing cells. The present invention also relates to methods of treating diabetes.