公开(公告)号：EP0989849A2

公开(公告)日：2000-04-05

申请号：EP98928941.8

申请日：1998-06-11

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： WALSH, Scott ,  RUBENSTEIN, Ronald ,  ZEITLIN, Pamela ,  LEONG, Kam

IPC分类号： A61K31/19 ,  A61K9/51

CPC分类号： A61K9/5169 ,  A61K31/192 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6435 ,  A61K47/6929 ,  A61K48/00 ,  B82Y5/00 ,  Y10S977/884 ,  Y10S977/906 ,  Y10S977/915 ,  Y10S977/92 ,  Y10S977/923

摘要： 4-Phenylbutyrate exerts many beneficial biological effects. It appears to induce the transcription of certain promoters, as well as having a remedial effect on proteins which are aberrantly localized within the cell. In addition, it appears to cause cells to developmentally differentiate. The present invention provides nanosphere formulations of 4-phenylbutyrate and other drugs which remediate defective protein localization intracellularly. These formulations permit lower concentrations of drugs to be administered, providing both cost and safety benefits.