公开(公告)号：EP2636735A4

公开(公告)日：2015-05-20

申请号：EP11832651

申请日：2011-10-13

申请人： TOKYO METROPOLITAN INST MEDICAL SCIENCE ,  CHEMO SERO THERAPEUT RES INST ,  UNIV HOKKAIDO NAT UNIV CORP

发明人： KOHARA MICHINORI ,  YASUI FUMIHIKO ,  MURAKAMI TOSHIO ,  KIDA HIROSHI ,  SAKODA YOSHIHIRO

IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K35/76 ,  A61K39/145 ,  A61K48/00 ,  A61P31/16 ,  C12N7/04

CPC分类号： A61K39/145 ,  A61K31/711 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/545 ,  C07K14/005 ,  C12N2710/24143 ,  C12N2760/16122 ,  C12N2760/16134

摘要： Provided are a highly-safe recombinant vaccinia virus that is effective in preventing the onset of symptoms due to infection by novel influenza viruses, and a vaccine for the novel influenza viruses containing the recombinant vaccinia virus. This recombinant vaccinia virus is capable of expressing the hemagglutinin protein genes of the novel influenza virus. This novel influenza vaccine contains the recombinant vaccinia virus.

公开(公告)号：EP2284260A4

公开(公告)日：2011-08-10

申请号：EP09726058

申请日：2009-03-26

申请人： UNIV HOKKAIDO NAT UNIV CORP ,  FUJIREBIO KK

发明人： KIDA HIROSHI ,  SAKODA YOSHIHIRO ,  MIYAGAWA EIJI ,  FUJII NOBUYUKI ,  UCHIDA YOSHIAKI ,  SHIRAKAWA TAKASHI ,  KOGAKI HIROYUKI

IPC分类号： C12N15/02 ,  C07K16/10 ,  C12N15/09 ,  G01N33/543 ,  G01N33/569 ,  G01N33/577

CPC分类号： G01N33/56983 ,  C07K16/1018 ,  C07K2317/34 ,  G01N2333/11

摘要： A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.