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公开(公告)号：EP0293793A3
公开(公告)日：1990-05-16
申请号：EP88108570.8
申请日：1988-05-28
CPC分类号： C07K1/1133 , C07K14/55 , C12N9/22 , C12N9/90 , C12Y503/04001
摘要： Protein disulfide isomerase, which catalyzes the exchange reaction between sulfhydryl and disulfide in a protein for formation of the most stable natural type disulfide bonds, is useful for formation of natural type disulfide bonds in a protein which is produced in a prokaryotic cell.
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公开(公告)号：EP0293793A2
公开(公告)日：1988-12-07
申请号：EP88108570.8
申请日：1988-05-28
CPC分类号： C07K1/1133 , C07K14/55 , C12N9/22 , C12N9/90 , C12Y503/04001
摘要： Protein disulfide isomerase, which catalyzes the exchange reaction between sulfhydryl and disulfide in a protein for formation of the most stable natural type disulfide bonds, is useful for formation of natural type disulfide bonds in a protein which is produced in a prokaryotic cell.
摘要翻译： 蛋白质二硫键异构酶，其催化在用于形成最稳定的天然型二硫键的蛋白质巯基和二硫键的交换反应，是在其在原核细胞中产生的蛋白质形成天然型二硫键是有用的。
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公开(公告)号：EP0277563A1
公开(公告)日：1988-08-10
申请号：EP88100923.7
申请日：1988-01-22
CPC分类号： C12N9/90
摘要： Bovine protein disulfide isomerase (PDI) is disclosed that is a polypeptide containing the amino acid sequence shown in Figure 3. Since the polypeptide has protein disulfide isomerase activity and it catalyzes the exchange reaction between sulfhydryl and disulfide in protein, the polypeptide can be used as a catalyst to re-construct protein having an natural-type disulfide bond from reduced-type protein and oxidized-type protein having unnatural-type disulfide bond.
摘要翻译： 公开了牛蛋白二硫键异构酶（PDI），其是含有图3所示氨基酸序列的多肽。由于多肽具有蛋白质二硫键异构酶活性，并且其催化蛋白质中巯基和二硫化物之间的交换反应，所以多肽可以用作 从还原型蛋白质重新构建具有天然型二硫键的蛋白质和具有非天然型二硫键的氧化型蛋白质的催化剂。
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公开(公告)号：EP0293793B1
公开(公告)日：1993-07-28
申请号：EP88108570.8
申请日：1988-05-28
CPC分类号： C07K1/1133 , C07K14/55 , C12N9/22 , C12N9/90 , C12Y503/04001
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