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公开(公告)号：EP0325199B1
公开(公告)日：1993-10-27
申请号：EP89100714.8
申请日：1989-01-17
IPC分类号： A61K31/335
CPC分类号： B82Y5/00 , A61K31/335 , A61K31/395 , A61K31/57 , A61K38/00 , A61K47/6951 , A61L27/54 , A61L2300/236 , A61L2300/416 , A61L2300/802 , C07K14/503 , C08B37/0012
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公开(公告)号：EP0325199A2
公开(公告)日：1989-07-26
申请号：EP89100714.8
申请日：1989-01-17
IPC分类号： A61K31/335
CPC分类号： B82Y5/00 , A61K31/335 , A61K31/395 , A61K31/57 , A61K38/00 , A61K47/6951 , A61L27/54 , A61L2300/236 , A61L2300/416 , A61L2300/802 , C07K14/503 , C08B37/0012
摘要： Fumagillin and its salts have an angiogenesis inhibiting activity and are useful for prophylaxis and treatment of diseases induced by abnormally stimulated neovascularization. The invention also provides certain pharmaceutical compositions comprising fumagillin or its salt, and an agent which potentiates angiogenesis inhibition such as heparin and sulfated cyclodextrins such as beta-cyclodextrin tetradecasulfate.
摘要翻译： 富马西林及其盐具有血管生成抑制活性，可用于预防和治疗由异常刺激的新血管形成引起的疾病。 本发明还提供了包含夫马洁林或其盐的某些药物组合物和增强血管生成抑制作用的药剂，例如肝素和硫酸化环糊精如β-环糊精十四硫酸盐。
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公开(公告)号：EP0325199A3
公开(公告)日：1991-05-08
申请号：EP89100714.8
申请日：1989-01-17
IPC分类号： A61K31/335
CPC分类号： B82Y5/00 , A61K31/335 , A61K31/395 , A61K31/57 , A61K38/00 , A61K47/6951 , A61L27/54 , A61L2300/236 , A61L2300/416 , A61L2300/802 , C07K14/503 , C08B37/0012
摘要： Fumagillin and its salts have an angiogenesis inhibiting activity and are useful for prophylaxis and treatment of diseases induced by abnormally stimulated neovascularization. The invention also provides certain pharmaceutical compositions comprising fumagillin or its salt, and an agent which potentiates angiogenesis inhibition such as heparin and sulfated cyclodextrins such as beta-cyclodextrin tetradecasulfate.
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