公开(公告)号：EP4410374A2

公开(公告)日：2024-08-07

申请号：EP24170493.1

申请日：2013-05-08

Applicant: Onyx Therapeutics, Inc.

Inventor： Lewis, Evan ,  Shwonek, Peter ,  Dalziel, Sean ,  Jumaa, Mouhannad

IPC: A61P35/00

CPC classification number: B82Y5/00 ,  A61K47/6951 ,  A61K38/07 ,  A61P19/08 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  A61P7/06

Abstract: This disclosure provides methods for formulating compositions comprising one or more peptide proteasome inhibitors and a cyclodextrin, particularly a substituted cyclodextrin. Such methods substantially increase the solubility and stability of these proteasome inhibitors and facilitate both their manufacture and administration.

公开(公告)号：EP4356929A1

公开(公告)日：2024-04-24

申请号：EP22202619.7

申请日：2022-10-19

Applicant: Universität Rostock

Inventor： Huling, Jennifer ,  Eickner, Thomas ,  Stefan Thomas, Oschatz ,  Grabow, Niels ,  Sterenczak, Katharina ,  Stahnke, Thomas ,  Stachs, Oliver ,  Füllen, Georg ,  Anselm, Jünemann

IPC: A61K47/69 ,  A61P27/02 ,  A61P27/06 ,  A61K31/407 ,  A61K31/7048 ,  A61K9/00 ,  A61K9/06 ,  A61K47/40

CPC classification number: A61K47/40 ,  A61K9/0048 ,  A61K9/0019 ,  A61K9/06 ,  A61K47/6951 ,  A61K47/6903 ,  A61P27/06 ,  A61P27/02 ,  A61K31/7048 ,  A61K31/407

Abstract: The present invention relates to a formulation of josamycin or a related compound in a crosslinked poly- or oligosaccharide, and the use of this formulation in ophthalmic treatment of infection and fibrosis.

公开(公告)号：EP2662094B1

公开(公告)日：2024-04-17

申请号：EP13167148.9

申请日：2013-05-08

IPC: A61K47/69 ,  A61K38/07 ,  B82Y5/00 ,  A61P35/00

CPC classification number: B82Y5/00 ,  A61K47/6951 ,  A61K38/07 ,  A61P19/08 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  A61P7/06

公开(公告)号：EP3235822A4

公开(公告)日：2018-08-01

申请号：EP15870103

申请日：2015-12-18

Applicant: UNIV NAGASAKI ,  UNIV KYOTO

Inventor： TANAKA YOSHIMASA ,  MATSUMOTO KENJI ,  HAYASHI KOSUKE ,  SAKAI YUKI ,  MINATO NAGAHIRO

IPC: C07F9/6539 ,  A61K31/663 ,  A61K31/675 ,  A61K47/40 ,  A61P31/12 ,  A61P31/16 ,  A61P31/18 ,  A61P31/22 ,  A61P35/00 ,  A61P35/02 ,  C07F9/40 ,  C07F9/58 ,  C07F9/60 ,  C07F9/6503 ,  C07F9/6512 ,  C07F9/6524 ,  C07F9/653 ,  C07F9/6561

CPC classification number: A61K31/675 ,  A61K31/663 ,  A61K45/06 ,  A61K47/40 ,  A61K47/6951 ,  C07F9/40 ,  C07F9/48 ,  C07F9/58 ,  C07F9/588 ,  C07F9/60 ,  C07F9/6503 ,  C07F9/65037 ,  C07F9/6512 ,  C07F9/65127 ,  C07F9/6524 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65395 ,  C07F9/6561

Abstract: The novel bisphosphonic acid ester derivatives represented by the following formula (1): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒY-Cy-(NH) m -(CH 2 ) n -C(X)(PO(OR 1 )(OR 2 )) 2 €ƒ€ƒ€ƒ€ƒ€ƒ(1) wherein each symbol is as defined in the DESCRIPTION, which has an amino group substituted by a heterocyclic group or a heterocyclic group containing a nitrogen atom, and the acid moiety is esterified with a POM group, an n-butanoyloxymethyl (BuOM) group and the like, exhibit a superior direct or indirect cytotoxicity effect on tumor cells and virus infected cells.

公开(公告)号：EP3110410B1

公开(公告)日：2018-05-09

申请号：EP15706481.7

申请日：2015-02-26

Applicant: SapioTec GmbH

Inventor： ROEWER, Norbert ,  BROSCHEIT, Jens

IPC: A61K31/02 ,  A61K31/08 ,  C08B37/16 ,  A61P23/00

CPC classification number: A61K31/075 ,  A61K47/6951 ,  C08B37/0015

公开(公告)号：EP2796140B1

公开(公告)日：2018-05-02

申请号：EP14166888.9

申请日：2008-01-23

Applicant: Pharmagra Labs, Inc.

Inventor： Frisbee, Albert, Roger ,  Newsome, Peter, Wyatt ,  Baudet, Michel, Pierre ,  Dagan, Ido, Dov

IPC: A61K31/70 ,  A61K31/40 ,  A61K8/00 ,  A61K31/26 ,  A61K47/40 ,  B82Y5/00

CPC classification number: A61K31/26 ,  A61K47/6951 ,  B82Y5/00 ,  C07C331/20 ,  C07C331/26 ,  C07C2601/14 ,  C07C2602/42 ,  C07F9/025 ,  C07F9/4006 ,  C08B37/0015 ,  C08L5/16

Abstract: A method of stabilizing sulforaphane is provided. The method includes contacting sulforaphane, or an analog thereof, and a cyclodextrin to form a complex between the sulforaphane, or analog thereof, and the cyclodextrin.

公开(公告)号：EP3310394A1

公开(公告)日：2018-04-25

申请号：EP16812564.9

申请日：2016-06-17

Applicant: Sage Therapeutics, Inc.

Inventor： SALITURO, Francesco, G. ,  ROBICHAUD, Albert, Jean ,  WATSON, Paul ,  HUNKE, William

IPC: A61K47/48 ,  A61K31/57

CPC classification number: A61K31/57 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/573 ,  A61K31/724 ,  A61K47/6951 ,  C08B37/0015

Abstract: Provided herein are pharmaceutically acceptable aqueous solution comprising a neuroactive steroid, a sulfobutyl ether beta cyclodextrin and a buffer; wherein: the solution is a stable solution between a pH of about 3 and about 9, e.g., at room temperature, for at least 1, 2, 3, 4 weeks; 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 months; 1, 2, 3 years or more; the buffer is present at a concentration of at least 0.1 mM; or the solution remains substantially free of impurities (e.g., the solution is substantially free of impurities at room temperature for at least 1, 2, 3, 4 weeks; 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 months; 1, 2, 3 years or more).

公开(公告)号：EP3302424A1

公开(公告)日：2018-04-11

申请号：EP16738214.2

申请日：2016-05-27

Applicant: Oculis EHF

Inventor： LOFTSSON, Thorsteinn

IPC: A61K9/00 ,  A61K47/48 ,  A61K9/50 ,  A61K9/51

CPC classification number: A61K47/6951 ,  A61K9/0048 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1682 ,  A61K38/13 ,  A61P27/04

Abstract: Methods of forming cyclosporin/cyclodextrin complex nanoparticles and microparticles, and administration of the nano- and microsuspension formed to an eye of a human or animal in the form of aqueous eye drops suitable to elicit or enhance tear formation and for treatment of diseases of the eye and surrounding areas. The aqueous eye drop composition contains cyclosporin and a mixture of α-cyclodextrin and γ-cyclodextrin as well as one or more stabilizing polymers. α-Cyclodextrin solubilizes cyclosporin while γ-cyclodextrin promotes formation of cyclosporin/cyclodextrin complex aggregates. The polymers stabilize the aqueous nano- and microsuspension.

公开(公告)号：EP1991201B1

公开(公告)日：2018-03-28

申请号：EP07703355.3

申请日：2007-02-08

Applicant: PARI Pharma GmbH

Inventor： KELLER, Manfred ,  AKKAR, Aslihan

IPC: A61K9/12 ,  A61K9/72 ,  A61K31/535 ,  A61K31/496 ,  A61K31/4709

CPC classification number: A61K9/0078 ,  A61K9/0043 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/535 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/6951 ,  B82Y5/00 ,  Y02A50/473 ,  Y02A50/478

Abstract: The present invention provides pharmaceutical aerosols which are useful for the prevention or treatment of infectious diseases of the airways, such as the lungs, the bronchi, or the sinunasal cavities. The aerosols comprise an active agent selected from the group of quinolone antibiotics. Also disclosed are liquid and solid compositions suitable for being converted into the aerosols, and kits comprising such compositions.

公开(公告)号：EP3094317A4

公开(公告)日：2017-11-22

申请号：EP15737304

申请日：2015-01-14

Applicant: UNIV JOHNS HOPKINS

Inventor： GESCHWIND JEAN-FRANCOIS ,  GANAPATHY-KANNIAPPAN SHANMUGASUNDARAM ,  KINZLER KENNETH W ,  VOGELSTEIN BERT ,  SUR SUROJIT

IPC: A61K31/02 ,  A61K9/08 ,  A61K9/14 ,  A61K9/19 ,  A61K31/19 ,  A61K45/06 ,  A61K47/40 ,  A61K47/69 ,  A61P35/00 ,  C08B37/16 ,  C08L5/16

CPC classification number: A61K9/146 ,  A61K9/08 ,  A61K9/19 ,  A61K31/02 ,  A61K31/19 ,  A61K45/06 ,  A61K47/40 ,  A61K47/6951 ,  C08B37/0012 ,  C08B37/0015 ,  C08L5/16 ,  A61K2300/00

Abstract: The invention provides compositions comprising cyclodextrins encapsulating a selective ATP inhibitor, as well as uses thereof.