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公开(公告)号：EP0091761B1
公开(公告)日：1987-11-19
申请号：EP83301847.6
申请日：1983-03-31
申请人： Takeda Chemical Industries, Ltd. , Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
IPC分类号： C07D277/34
CPC分类号： C07D277/34 , Y10S514/866
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公开(公告)号：EP0091761A3
公开(公告)日：1984-12-27
申请号：EP83301847
申请日：1983-03-31
申请人： Takeda Chemical Industries, Ltd. , Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
IPC分类号： C07D277/34 , C07D277/54
CPC分类号： C07D277/34 , Y10S514/866
摘要： A new thiazolidine derivative of the formula:
where n stands for an integer of 3 to 6 and salts thereof show strong aldose reductase inhibition and are useful for prophylaxis or therapy of diabetic cataract, diabetic neuropathy in mammals.-
公开(公告)号：EP0091761A2
公开(公告)日：1983-10-19
申请号：EP83301847.6
申请日：1983-03-31
申请人： Takeda Chemical Industries, Ltd. , Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
IPC分类号： C07D277/34
CPC分类号： C07D277/34 , Y10S514/866
摘要： A new thiazolidine derivative of the formula:
where n stands for an integer of 3 to 6 and salts thereof show strong aldose reductase inhibition and are useful for prophylaxis or therapy of diabetic cataract, diabetic neuropathy in mammals.-
4.发明公开Thiazolidine derivatives and their production and medicinal compositions containing them 失效噻唑烷衍生物以及它们的制备方法和它们的药物组合物。
公开(公告)号：EP0033617A2
公开(公告)日：1981-08-12
申请号：EP81300308.4
申请日：1981-01-23
申请人： Takeda Chemical Industries, Ltd. , Senju Seiyaku Kabushiki Kaisha also known as Senju Pharmaceutical Co. Ltd.
IPC分类号： C07D277/34 , C07D409/04 , A61K31/425 , C07D277/54 , C07D277/40
CPC分类号： C07D417/04 , C07C255/00 , C07D277/34 , C07D277/40 , C07D277/54
摘要： A thiazolidine derivatives of the formula:
wherein R is a phenyl group having 2 nuclear substituent groups selected from the class consisting of a lower alkyl having 1 to 6 carbon atoms, a lower alkoxy having 1 to 7 carbon atoms, hydroxyl and a carboxylic acyloxy having 1 to4 carbon atoms or a phenyl group having a methylenedioxy group in adjacent positions on its ring; R' is H or an alkyl having 1 to 6 carbon atoms, or a physiologically acceptable salt thereof is a novel compound and is having the activity to control certain chronic symptoms due to diabetes, such as diabetic cataract, diabetic neuropathy and diabetic retinosis.-
公开(公告)号：EP0033617A3
公开(公告)日：1981-08-26
申请号：EP81300308
申请日：1981-01-23
IPC分类号： C07D277/34 , C07D409/04 , A61K31/425 , C07D277/54 , C07D277/40
CPC分类号： C07D417/04 , C07C255/00 , C07D277/34 , C07D277/40 , C07D277/54
摘要： A thiazolidine derivatives of the formula:
wherein R is a phenyl group having 2 nuclear substituent groups selected from the class consisting of a lower alkyl having 1 to 6 carbon atoms, a lower alkoxy having 1 to 7 carbon atoms, hydroxyl and a carboxylic acyloxy having 1 to4 carbon atoms or a phenyl group having a methylenedioxy group in adjacent positions on its ring; R' is H or an alkyl having 1 to 6 carbon atoms, or a physiologically acceptable salt thereof is a novel compound and is having the activity to control certain chronic symptoms due to diabetes, such as diabetic cataract, diabetic neuropathy and diabetic retinosis.-
公开(公告)号：EP0032128A1
公开(公告)日：1981-07-15
申请号：EP81300027.0
申请日：1981-01-06
发明人： Kawamatsu, Yutaka , Shoda, Takashi , Hirata, Takeo
IPC分类号： C07D277/34 , A61K31/425 , C07D277/54
CPC分类号： C07D277/54 , Y10S514/926 , Y10S514/927
摘要： A thiazolidine derivative of the formula:
wherein R is hydrogen, hydroxyl, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms, or lower carboxylic acyloxy having 2 to4 carbon atoms; each of R 2 and R 3 is hydroxyl, lower alkyl having 1 to4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms or lower carboxylic acyloxy having 2 to 4 carbon atoms or pharmaceutically acceptable salt thereof is a novel compound and having antiulcer activity and inhibitory effect of gastric acid secretion. The compound is useful as antiulcer agent or inhibitory agent of gastric acid secretion.-
7.发明公开2-Amino-4-(4-benzyloxyphenyl)thiazoles, their production and pharmaceutical compositions containing them 失效2-氨基-4-（4-苄氧基苯基）噻唑，它们的制备和含有它们的药物组合物。
公开(公告)号：EP0027957A1
公开(公告)日：1981-05-06
申请号：EP80106271.2
申请日：1980-10-15
发明人： Kawamatsu, Yutaka , Sohda, Takashi , Imai, Yoshio
IPC分类号： C07D277/40 , C07D277/42 , C07D277/46 , A61K31/425
CPC分类号： C07D277/46 , C07D277/40 , C07D277/42
摘要： 2-Amino-4-(4-benzyloxyphenyl)thiazole compounds of the formula:
wherein X is hydrogen, a halogen, a lower alkyl having 1 to 4 carbon atoms or trifluoromethyl; R is hydrogen, a lower alkyl having 1 to 4 carbon atoms, a lower alkenyl having 2 to 4 carbon atoms or an acyl having 1 to 6 carbon atoms; n is 1 or 2, or pharmaceutically acceptable salts thereof, are novel compounds and are useful as a prophylactic agent or therapeutic agent of hyperlipemia, atherosclerosis and heart diseases attributable to them in mammals including human beings.-
公开(公告)号：EP0084926A1
公开(公告)日：1983-08-03
申请号：EP83300043.3
申请日：1983-01-05
发明人： Kawamatsu, Yutaka , Fujita, Takeshi
IPC分类号： C07D277/34 , A61K31/425
CPC分类号： C07D307/77 , C07C59/72 , C07C62/04 , C07D277/34 , C07D309/12 , C07D317/72 , Y10S514/866
摘要： thiazolidine derivative of the general formula,
wherein
is a cyclohexane ring having an oxo or hydroxyl group as a substituent on any of the methylene groups constituting the ring and R is a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms, is a novel compound and is useful as, for example, remedies for diabetes, hyperlipemia and so on of mammals including human beings.摘要翻译： 通式的噻唑烷衍生物，其中，是在构成环的亚甲基的任一个上具有氧代或羟基作为取代基的环己烷环，R为氢原子或碳原子数为1〜4的低级烷基， 新型化合物，可用作例如包括人在内的哺乳动物的糖尿病，高脂血症等的治疗。
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公开(公告)号：EP0067718A1
公开(公告)日：1982-12-22
申请号：EP82303121.6
申请日：1982-06-16
IPC分类号： C07D213/30 , A01N47/30
CPC分类号： C07D213/30 , A01N47/30
摘要： Urea derivatives of the general formula:
wherein R' stands for a lower alkyl group; and R 2 stands for a lower alkyl group or a lower alkoxy group, or a salt thereof, are novel and have a strong herbicidal activity against various species of weeds and shows a very low phytotoxicity to crop plants.
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