专利检索 ap:("Talecris Biotherapeutics, Inc.") AND inv:"LANDSKRONER, Kyle, A." 第 1 页

1.

发明授权
METHOD OF THROMBOLYSIS BY LOCAL DELIVERY OF REVERSIBLY INACTIVATED ACIDIFIED PLASMIN 有权
标题翻译：方法溶栓治疗以局部治疗具有可逆性灭活酸化纤溶酶

公开(公告)号：EP1232251B1

公开(公告)日：2007-08-15

申请号：EP00978572.6

申请日：2000-11-13

申请人： Talecris Biotherapeutics, Inc.

发明人： NOVOKHATNY, Valery, B. , JESMOK, Gary, J. , LANDSKRONER, Kyle, A. , TAYLOR, Kathryn, K. , ZIMMERMAN, Thomas, P.

IPC分类号： C12N9/48 , C12N9/72 , C12N9/68 , A61K38/48

CPC分类号： C12N9/6435 , A61K38/4833 , A61K38/484 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , C12N9/96 , C12N9/99 , C12Y304/21007

摘要： The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.