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公开(公告)号：EP0716856A3
公开(公告)日：1996-10-30
申请号：EP96101815.7
申请日：1989-05-24
CPC分类号： A61K31/70 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K47/554 , C07H21/00 , C07H23/00
摘要： Synthetic analogs of 2',5'-oligoadenylate wherein the aglycon, ribosyl moiety and/or terminal nucleoside have been modified are effective therapeutic agents, particularly against HIV infection. The analogs are utilized in compositions for the treatment of disorders characterized by 2-5A pathway defects.
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2.发明公开
公开(公告)号：EP0694559A2
公开(公告)日：1996-01-31
申请号：EP95202077.4
申请日：1988-10-18
CPC分类号： C07H21/00 , Y10S514/889
摘要： There are disclosed: a method of controlling viral infection in plants comprising administering an antiviral effective amount of the compound ( R p)-P-thioadenylyl-(2'-5')-( R p)-P-thioadenylyl-(2'-5')-adenosine, the 5'-monophosphate thereof, or a water-soluble salt of either compound; a conjugate of poly (L-lysine) and 2'-5'-phosporothioate oligoadenylate (for formula see claim 2); and a compound of the formula
wherein m is zero, 1, 2 or 3 and n is 2, and water-soluble salts thereof.摘要翻译： 公开了一种控制植物病毒感染的方法，该方法包括给予抗病毒有效量的化合物（Rp）-β-硫代腺苷酰 - （2'-5'） - （Rp）-β-硫代腺苷酰 - （2'-5 '） - 腺苷，其5'-单磷酸盐或任何一种化合物的水溶性盐; （L-赖氨酸）和2'-5'-硫代磷酸寡聚腺苷酸的结合物（对于结构式见权利要求2）; 和下式化合物及其水溶性盐，其中m为0,1,2或3，n为2。
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公开(公告)号：EP0694559B1
公开(公告)日：1999-04-14
申请号：EP95202077.4
申请日：1988-10-18
CPC分类号： C07H21/00 , Y10S514/889
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4.发明公开Therapeutic uses of 2',5'-oligoadenylate derivatives 失效Therapeutische Anwendungen von 2'，5'-Oligoadenylat-Derivaten
公开(公告)号：EP0716856A2
公开(公告)日：1996-06-19
申请号：EP96101815.7
申请日：1989-05-24
CPC分类号： A61K31/70 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K47/554 , C07H21/00 , C07H23/00
摘要： Synthetic analogs of 2',5'-oligoadenylate wherein the aglycon, ribosyl moiety and/or terminal nucleoside have been modified are effective therapeutic agents, particularly against HIV infection. The analogs are utilized in compositions for the treatment of disorders characterized by 2-5A pathway defects.
摘要翻译： 其中糖苷配基，核糖基部分和/或末端核苷已被修饰的2'，5'-寡腺苷酸的合成类似物是有效的治疗剂，特别是抗HIV感染。 类似物用于治疗以2-5A途径缺陷为特征的疾病的组合物中。
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公开(公告)号：EP0716856B1
公开(公告)日：2001-08-29
申请号：EP96101815.7
申请日：1989-05-24
IPC分类号： A61K31/047 , C07H21/00
CPC分类号： A61K31/70 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K47/554 , C07H21/00 , C07H23/00
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公开(公告)号：EP0694559A3
公开(公告)日：1996-07-31
申请号：EP95202077.4
申请日：1988-10-18
CPC分类号： C07H21/00 , Y10S514/889
摘要： There are disclosed: a method of controlling viral infection in plants comprising administering an antiviral effective amount of the compound ( R p)-P-thioadenylyl-(2'-5')-( R p)-P-thioadenylyl-(2'-5')-adenosine, the 5'-monophosphate thereof, or a water-soluble salt of either compound; a conjugate of poly (L-lysine) and 2'-5'-phosporothioate oligoadenylate (for formula see claim 2); and a compound of the formula
wherein m is zero, 1, 2 or 3 and n is 2, and water-soluble salts thereof.
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