公开(公告)号：EP4408525A1

公开(公告)日：2024-08-07

申请号：EP22877626.6

申请日：2022-09-30

申请人： Adarx Pharmaceuticals, Inc.

发明人： LI, Zhen ,  ZHU, Rui ,  ZHOU, Zhiqing (Joel) ,  FULTZ, Kimberly

IPC分类号： A61P9/12 ,  C07H21/02 ,  C12N15/113 ,  A61K31/712 ,  A61K31/713 ,  A61K31/7125

CPC分类号： A61K31/713 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  C12N15/113 ,  C12N2310/1420130101 ,  C12N2310/31520130101 ,  C12N2310/35120130101 ,  C07H21/02 ,  C07H21/04

公开(公告)号：EP3610035B1

公开(公告)日：2024-06-05

申请号：EP18784503.7

申请日：2018-04-13

IPC分类号： C12Q1/68 ,  C12N15/10

CPC分类号： A61K31/7088 ,  C12Q1/68 ,  A61K31/7105 ,  A61K31/7115 ,  A61P35/00 ,  C12N15/101 ,  A61K35/17

公开(公告)号：EP4367244A1

公开(公告)日：2024-05-15

申请号：EP22836938.5

申请日：2022-07-06

申请人： Ractigen Therapeutics

发明人： KANG, Moorim ,  LI, Longcheng ,  PLACE, Robert F.

IPC分类号： C12N15/113 ,  A61K38/14

CPC分类号： C12N2310/1420130101 ,  C12N2310/31520130101 ,  C12N2310/33520130101 ,  C12N2310/334120130101 ,  C12N2310/312520130101 ,  C12N2310/32120130101 ,  C12N2310/32220130101 ,  C12N2310/351920130101 ,  C12N2310/1120130101 ,  C12N15/1137 ,  C12Y115/01001 ,  C12N2310/351720130101 ,  A61K31/712 ,  A61K31/7115

公开(公告)号：EP4365288A1

公开(公告)日：2024-05-08

申请号：EP22833314.2

申请日：2022-06-30

申请人： Kyowa Kirin Co., Ltd. ,  National University Corporation Tokai National Higher Education and Research System

发明人： IWAI, Hiroto ,  HOMMA, Masakazu ,  ATAGO, Takayuki ,  YAMAMOTO, Junichiro ,  ABE, Hiroshi ,  KIMURA, Yasuaki

IPC分类号： C12N15/11 ,  A61K31/7088 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K48/00 ,  A61P43/00 ,  C07H21/02 ,  C07H21/04 ,  C12N5/10 ,  C12N15/67 ,  C12P21/02

CPC分类号： A61K31/7088 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K48/00 ,  A61P43/00 ,  C07H21/02 ,  C07H21/04 ,  C12N5/10 ,  C12N15/67 ,  C12N15/11 ,  C12P21/02

摘要： The present invention relates to a polynucleotide, containing a translated region from a start codon to a stop codon, a 5' untranslated region, and a poly A chain, in which 65% or more of nucleotides contained in the poly A chain are sugar modified nucleotides.

公开(公告)号：EP3408276A1

公开(公告)日：2018-12-05

申请号：EP17712541.6

申请日：2017-01-27

申请人： Uniwersytet Warszawski

发明人： JEMIELITY, Jacek ,  FAC-DABROWSKA, Kaja ,  WOJTCZAK, Blazej ,  BARANOWSKI, Marek ,  NOWICKA, Anna ,  KOWALSKA, Joanna ,  SIKORSKI, Pawel ,  WARMINSKI, Marcin

IPC分类号： C07H21/00 ,  A61K31/7084 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  C07H21/02 ,  A61P21/00

CPC分类号： C07H21/00 ,  A61K31/7084 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  C07H21/02

摘要： The present invention relates to nucleotides, analogs of mRNA 5'-end (cap) containing sulfur atom at the position 5' of 7-methylguanosine nucleoside. The disclosed compounds are recognized (bound and non-hydrolyzed) by DcpS enzyme (Decapping Scavenger), and thus may find therapeutic use as inhibitors thereof. DcpS is cap-specific enzyme with pyrophosphatase activity, which was identified as a therapeutic target in the treatment of spinal muscular atrophy (SMA). Some of the compounds disclosed have additional modifications in the phosphate chain, wh ich modulate their affinity for DcpS enzyme. The present invention also relates to mRNAs modified at the 5' end with mRNA 5'-end (cap) analogs containing 5'- phosphorothiolate moiety, which mRNAs have an increased stability and translational activity in cellular conditions, to a method of their preparation, their uses, and to a pharmaceutical formulation containing them, wherein L1 and L2 are independently selected from the group comprising O and S, wherein at least one of L1 and L2 is not O.

公开(公告)号：EP3365008A1

公开(公告)日：2018-08-29

申请号：EP16858402.7

申请日：2016-10-21

申请人： ModernaTX, Inc.

发明人： CIARAMELLA, Giuseppe ,  BAHL, Kapil ,  ESPESETH, Amy ,  WANG, Dai ,  BETT, Andrew, J.

IPC分类号： A61K39/155 ,  A61K31/7105 ,  A61K31/7115 ,  A61P31/14

CPC分类号： A61K39/12 ,  A61K31/7105 ,  A61K31/7115 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55555 ,  C12N2760/18534 ,  Y02A50/39

摘要： The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：EP2694660B1

公开(公告)日：2018-08-08

申请号：EP12767300.2

申请日：2012-03-12

申请人： The General Hospital Corporation ,  Children's Medical Center Corporation

发明人： CHIEN, Kenneth, R. ,  PTASZEK, Leon, M. ,  LUI, Oi Lan ,  ZANGI, Lior ,  EBINA, Wataru ,  ROSSI, Derrick J.

IPC分类号： C12N15/87 ,  C12N15/11 ,  A61K48/00 ,  A61P43/00 ,  A61P35/00 ,  A61K31/7115

CPC分类号： A61K38/1866 ,  A01K67/0276 ,  A01K2207/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0393 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/555 ,  A61K31/7068 ,  A61K31/7115 ,  A61K33/24 ,  A61K48/005 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/258 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2800/30 ,  A61K2300/00

摘要： Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.

公开(公告)号：EP2847321B1

公开(公告)日：2018-03-14

申请号：EP13720885.6

申请日：2013-04-26

申请人： CiMaas B.V.

发明人： BOS, Gerardus Marinus Josef ,  GERMERAAD, Wilfred Thomas Vincent ,  GIJSBERS, Lamberta Maria Gerardina ,  OTH, Tammy ,  VANDERLOCHT, Joris

IPC分类号： C12N5/0784 ,  A61K35/14 ,  A61K39/39 ,  A61K39/108 ,  A61K38/21 ,  A61K31/713 ,  A61K31/38

CPC分类号： A61K31/4745 ,  A61K31/7115 ,  A61K35/15 ,  C12N5/0639 ,  C12N2500/72 ,  C12N2501/05 ,  C12N2501/056 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/24 ,  C12N2501/998 ,  C12N2501/999 ,  A61K2300/00

摘要： The invention is in the field of cell biology and immunology. The invention provides methods for the production of a vaccine for cancer and infectious diseases. More in particular it provides a method for the production of mature dendritic cells wherein immature dendritic cells are exposed to a composition comprising FMKp and interferon gamma in combination with CL075 and/or Poly IC in a culture medium for a sufficient amount of time and wherein mature dendritic cells are isolated from the culture medium.

公开(公告)号：EP3289083A1

公开(公告)日：2018-03-07

申请号：EP16787068.2

申请日：2016-04-27

申请人： The Trustees of The University of Pennsylvania ,  Acuitas Therapeutics Inc. ,  Tam, Ying ,  Hope, Michael J.

发明人： TAM, Ying ,  HOPE, Michael, J. ,  WEISSMAN, Drew ,  PARDI, Norbert

IPC分类号： C12N15/11 ,  A61K31/7115 ,  A61K31/712 ,  A61K9/127 ,  C07D295/13 ,  C07C219/08

CPC分类号： A61K39/12 ,  A61K9/0019 ,  A61K9/127 ,  A61K31/7115 ,  A61K31/712 ,  A61K39/0011 ,  A61K39/002 ,  A61K39/02 ,  A61K2039/51 ,  A61K2039/55555 ,  A61P31/16 ,  A61P31/18 ,  A61P35/00 ,  C07C219/08 ,  C07D295/13 ,  C12N15/11

摘要： The present invention relates to compositions and methods for inducing an adaptive immune response in a subject. In certain embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding an antigen, adjuvant, or a combination thereof. For example, in certain embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding an antigen, adjuvant, or a combination thereof.

公开(公告)号：EP3277289A1

公开(公告)日：2018-02-07

申请号：EP16774322.8

申请日：2016-04-01

申请人： Arcturus Therapeutics, Inc.

发明人： CHIVUKULA, Padmanabh ,  TACHIKAWA, Kiyoshi ,  PAYNE, Joseph E.

IPC分类号： A61K31/7105 ,  A61K31/711 ,  A61K31/7125

CPC分类号： C12N15/1131 ,  A61K31/7105 ,  A61K31/7115 ,  A61K31/7125 ,  A61K31/713 ,  A61P9/00 ,  A61P25/00 ,  A61P31/14 ,  C07H21/00 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/323 ,  C12N2310/346 ,  C12N2320/51 ,  C12N2320/52 ,  A61K2300/00

摘要： This invention provides UNA oligomers for regulating the expression of a target gene. The UNA oligomers contain UNA monomer linkers, and may contain one or more nucleotides modified with a 2′-O-methyl group, one or more nucleotides modified with a 2′-deoxy-2′-fluoro group, and one or more phosphorothioate or chiral phosphorothioate intermonomer linkages. UNA oligomers can be used as active agents for preventing or treating disease.